patient aged 18 to 75 years

patient with ipah ot cpeph stable for at least 3 months. stability is defined by the new york heart association classes for dyspnea and the six minutes walking test (6mwt). furthermore, no changes in medical therapy had occured during the last three months.

patients who signed informed consent

patients with secondary ph associated with other pathologies outside cpeph ( sclerodermia, systemic lupus erythematous, portal hypertension, chronic hiv infection...)

patients who had a functional and/or a hemodynamic degradation during the last 3 months or a change in pulmonary hypertension treatment

patients with obstructive or restrictive ventilatory disorder with a ventricular ejection fraction <60% predicted

women without effective contraception

patients with a body mass index above 35 kg/m2

patient not affiliated to a social security scheme