active rheumatoid arthritis (ra) for 6 months or more.

males or nonpregnant, nonlactating femails aged 20 to 75 years, inclusive.

body mass index (bmi) between 19 and 36 kg/m2 and weight between 50 and 145 kg, inclusive.

males, unless surgically sterile, must use 2 effective methods of birth control from day 1 through follow-up.

history or presence of any clinically significant disease or disorder which has not been stable over the previous 3 months.

history of liver disease, bilirubin elevations, or gilbert's syndrome.

any systematic inflammatory condition in addition to ra (polymyalgia rheumatica, giant cell arthritis, systemic lupus, gout, pyrophosphate arthropathy).

current, chronic pain disorders including fibromyalgia and chronic regional pain syndromes or chronic fatigue syndromes.

intramuscular steroid injection or intraarticular steroid injection within 1 month of enrollment.