stage iv renal cancer

measurable disease

life expectancy > 3 months

adequate organ and marrow function

clinical evidence of central nervous system (cns) disease. subjects with a history of treated brain metastasis must be stable with no evidence of disease for 3 months

clinically significant autoimmune disease

hiv+

serious intercurrent illness such as infection requiring intravenous (iv) antibiotics, or significant cardiac disease characterized by significant arrhythmia, uncontrolled hypertension, unstable ischemic coronary disease or congestive heart failure

pregnant or lactating

history of clinically significant venous thromboembolism (for cohort 2)