all patients in asa score i - iii, planned to be treated with open radical nephrectomy or nephron-sparing surgery having renal cell carcinoma

patients in asa score iv-v,

patients with advanced tumour thrombus in vena cava inferior,

patients with high risk for bleeding

patients with previous chronic pain symptoms

patients having drug abuse

patients having cognitive deficiencies or dementia disease

patients with any contraindication of either spinal or epidural anesthesia

patients younger than 18 years and pregnant woman

patients having a weight less than 45 kg or weight over 120 kg