parkinson's disease patients in accordance with uk queensquare brain bank

modified hoehn & yahr stage <3

dopamine agents(levodopa, dopamine agonists) naive patients, or the patients who have discontinued the agents at least four weeks before the screening in case of using the dopamine agents are administered before.

k-mmse<24

history of drug-induced parkinsonism

secondary parkinsonism

history of schizophrenia or hallucination

requirement of treatment with anti-depressants due to depressive disorder

pregnant and/or breeding women

renal inadequacy