diagnosis of sle for at least 6 months as defined by the most recent american college of rheumatology criteria

presence of lupus related inflammatory arthritis with at least four tender and four swollen joints; and systemic lupus erythematosus disease activity index (sledai) ≥ 6 at screening;

other inclusion criteria may apply.

presence or history of vasculitis, and presence or history of active lupus nephritis requiring therapy within the last 3 years

any disorder (including psychiatric), condition, clinically significant disease, disease activity related to sle

positive for hiv antibodies, hepatitis b surface antigen or anti-hbc, or hepatitis c antibodies

known residential exposure to an individual with tuberculosis or positive quantiferon test or ppd test at screening

men and women of reproductive potential, unwilling to practice a highly effective method of birth control for the duration of the study

other exclusion criteria may apply