men and women from 18 to 80 years

patients with angina pectoris iii-iv functional class

patients signed informed consent

intolerance of heparin and hes.

hypothyroidism and hyperthyroidism.

associated pathology with a projected lifespan limitation to 3 years.

infection diseases

simultaneous participation in another study.

pregnancy.

severe mental disorder.

refusal of a patient to participate in the study.