age ≥18 years

patients who receive a primary or secondary pancreas transplant, with or without a simultaneous kidney transplant (spk).

women who are of childbearing potential must have a negative serum pregnancy test at baseline.

operability has to be ascertained by preoperative examination, performed by nephrologist, transplant surgeon and anaesthesiologist.

signed and dated informed consent form.

evidence of systemic infection

presence of unstable cardiovascular disease.

malignancy < 5 years prior to entry into the trial (with the exception of adequately treated basal cell or squamous cell carcinomas of the skin).

panel-reactive antibodies (pra) > 20% or the presence of donor-specific antigens (dsa).

any positive test for hbv, hbc or hiv.