men and women 18-70

currently meet the dsm-v criteria for major depressive disorder (mdd)

the patient must have an ongoing major depressive episode of at least 8 weeks and no more than 18 months

the patient must have at least 3 lifetime episodes of mdd (including the current episode)

women who are pregnant, women who will be breastfeeding during the study, and women with childbearing potential who are not practicing a reliable method of birth control

patients who are considered a suicide risk

history of non-response to 2 or more antidepressants (after adequate treatment)

patients who have a history of meeting the diagnostic and statistical manual of mental disorders, fifth edition (dsm-5) criteria for manic, hypomanic, or mixed episodes schizophrenia or other psychotic disorder obsessive-compulsive disorder

panic disorder