Age | Hypertensive disease Stage | Sitting diastolic blood pressure | Sitting diastolic blood pressure Untreated
Item
men or women over 21 years of age with a history of stage 1 or 2 hypertension (defined as a seated diastolic bp ≥ 90 mmhg and < 110 mmhg in the untreated state).
boolean
C0001779 (UMLS CUI [1])
C0020538 (UMLS CUI [2,1])
C0205390 (UMLS CUI [2,2])
C1319894 (UMLS CUI [3])
C1319894 (UMLS CUI [4,1])
C0745134 (UMLS CUI [4,2])
On treatment for hypertension | Antihypertensive Agents Discontinue Willing | Antihypertensive Agents Discontinue Able
Item
patients under treatment for hypertension must be willing and able to discontinue any previous antihypertensive medications for the duration of the study.
boolean
C0578998 (UMLS CUI [1])
C0003364 (UMLS CUI [2,1])
C1444662 (UMLS CUI [2,2])
C0600109 (UMLS CUI [2,3])
C0003364 (UMLS CUI [3,1])
C1444662 (UMLS CUI [3,2])
C0085732 (UMLS CUI [3,3])
25-Hydroxyvitamin D Measurement
Item
25-hydroxyvitamin d levels < 30 ng/ml and > 12 ng/ml.
boolean
C2984945 (UMLS CUI [1])
Childbearing Potential Contraceptive methods | Childbearing Potential Serum pregnancy test negative | Childbearing Potential Urine pregnancy test negative | aliskiren
Item
women of childbearing potential must be using a medically acceptable form of birth control for the duration of the trial, must have a negative serum pregnancy test at screening, and must have a negative urine pregnancy test within 7 days before initiating aliskiren therapy.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C3831118 (UMLS CUI [2,1])
C0430061 (UMLS CUI [2,2])
C3831118 (UMLS CUI [3,1])
C0430057 (UMLS CUI [3,2])
C1120110 (UMLS CUI [4])
Vitamin D measurement
Item
vitamin d levels < 12 ng/ml
boolean
C0919758 (UMLS CUI [1])
Hypersensitivity Aliskiren
Item
known hypersensitivity or allergy to aliskiren
boolean
C0020517 (UMLS CUI [1,1])
C1120110 (UMLS CUI [1,2])
Blood pressure determination
Item
clinic blood pressure > 180/110 mmhg
boolean
C0005824 (UMLS CUI [1])
Secondary hypertension
Item
known forms of secondary hypertension
boolean
C0155616 (UMLS CUI [1])
Chronic atrial fibrillation
Item
chronic atrial fibrillation
boolean
C0694539 (UMLS CUI [1])
Cardiovascular Diseases Uncontrolled | Cardiovascular Diseases Unstable
Item
uncontrolled or unstable cardiovascular diseases
boolean
C0007222 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0007222 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
Shift worker | Night shift worker
Item
shift or night workers
boolean
C0425104 (UMLS CUI [1])
C0555008 (UMLS CUI [2])
Mid arm muscle circumference Diameter
Item
mid-arm circumference > 42 cm in diameter
boolean
C0562347 (UMLS CUI [1,1])
C1301886 (UMLS CUI [1,2])
Substance Use Disorders
Item
current or recent (<1 year) alcohol or drug abuse
boolean
C0038586 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
pregnant or lactating women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])