Insulin-Dependent Diabetes Mellitus Disease length | Age | Glucagon Injection Intravenous | Reduced C-peptide level Percentage
Item
t1dm patients that are over 18 years of age, have had t1dm for greater than 5 years and show a greater than 80% reduction in c-peptide blood levels following intravenous glucagon injection are eligible to participate in this study.
boolean
C0011854 (UMLS CUI [1,1])
C0872146 (UMLS CUI [1,2])
C0001779 (UMLS CUI [2])
C4026725 (UMLS CUI [3,1])
C1522726 (UMLS CUI [3,2])
C4280764 (UMLS CUI [4,1])
C0439165 (UMLS CUI [4,2])
Healthy Control | Age | Glucagon Injection Intravenous | Blood insulin C-peptide normal | Age matched Insulin-Dependent Diabetes Mellitus Patient | Gender matched Insulin-Dependent Diabetes Mellitus Patient
Item
healthy controls that are over 18 years of age, show normal c-peptide blood levels following intravenous glucagon injection, and are age- and sex-matched with one of the t1dm patients included in the study, are eligible to participate in this study.
boolean
C2986479 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
C4026725 (UMLS CUI [3,1])
C1522726 (UMLS CUI [3,2])
C0855719 (UMLS CUI [4])
C0001779 (UMLS CUI [5,1])
C0150103 (UMLS CUI [5,2])
C0011854 (UMLS CUI [5,3])
C0030705 (UMLS CUI [5,4])
C0079399 (UMLS CUI [6,1])
C0150103 (UMLS CUI [6,2])
C0011854 (UMLS CUI [6,3])
C0030705 (UMLS CUI [6,4])
Age
Item
t1dm patients or healthy controls that are not over 18 years of age are not eligible to participate in this study.
boolean
C0001779 (UMLS CUI [1])
Pregnancy | Cause PET/CT scan Risk | Childbearing Potential Urine pregnancy test
Item
pregnant females are not eligible to participate in this study because there is a chance pet/ct scans might be risky for the developing baby. females physically capable of getting pregnant will be required to get a urine pregnancy test at no cost before each of the pet/ct scans. if the pregnancy test is positive, the t1dm patient or healthy control will be excluded from the study. the consent form describes the risks in detail and the need for women of childbearing age to undergo a pregnancy test.
boolean
C0032961 (UMLS CUI [1])
C0015127 (UMLS CUI [2,1])
C1699633 (UMLS CUI [2,2])
C0035647 (UMLS CUI [2,3])
C3831118 (UMLS CUI [3,1])
C0430056 (UMLS CUI [3,2])
Mental disorders | Substance Use Disorders | Craniocerebral Trauma | Nervous system disorder | Cardiovascular Disease | Liver disease | Renal Insufficiency | Claustrophobia
Item
subjects with a history of psychiatric illness, substance abuse history, clinically significant head trauma, active neurological disease, cardiovascular disease, liver disease or renal impairment, claustrophobia ((very upset and afraid of being in a small space) are not eligible for the study. dr. ping wang will use the subjects history, blood chemistry, to identify individuals with cardiovascular disease, liver disease, or renal impairment.
boolean
C0004936 (UMLS CUI [1])
C0038586 (UMLS CUI [2])
C0018674 (UMLS CUI [3])
C0027765 (UMLS CUI [4])
C0007222 (UMLS CUI [5])
C0023895 (UMLS CUI [6])
C1565489 (UMLS CUI [7])
C0008909 (UMLS CUI [8])
Diabetes Mellitus, Insulin-Dependent | Glucagon Injection Intravenous | Absence Reduced C-peptide level Percentage
Item
t1dm patients with c-peptide levels following intravenous glucagon injection that are not reduced greater than 80% are not eligible for the study.
boolean
C0011854 (UMLS CUI [1])
C4026725 (UMLS CUI [2,1])
C1522726 (UMLS CUI [2,2])
C0332197 (UMLS CUI [3,1])
C4280764 (UMLS CUI [3,2])
C0439165 (UMLS CUI [3,3])
Healthy Volunteers | Glucagon Injection Intravenous | Reduced C-peptide level Percentage
Item
healthy volunteers with c-peptide levels following intravenous glucagon injection that are reduced greater than 20% compared to established control values are not eligible for the study.
boolean
C1708335 (UMLS CUI [1])
C4026725 (UMLS CUI [2,1])
C1522726 (UMLS CUI [2,2])
C4280764 (UMLS CUI [3,1])
C0439165 (UMLS CUI [3,2])
Exposure to Therapeutic radiology procedure | Exposure to X-ray diagnosis | Exposure to X-Ray Therapy | Craniocerebral Trauma | Kidney Diseases | Urinary Bladder Diseases | Other medical condition Serious
Item
to determine if it is safe to do the procedure, t1dm patients and healthy volunteers will be expected to tell the researchers about any radiation exposure the individual may have had (including diagnostic or treatment x-rays), and any history of head injury, kidney or bladder disease, or any other serious medical conditions.
boolean
C0332157 (UMLS CUI [1,1])
C1522449 (UMLS CUI [1,2])
C0332157 (UMLS CUI [2,1])
C0034571 (UMLS CUI [2,2])
C0332157 (UMLS CUI [3,1])
C0043308 (UMLS CUI [3,2])
C0018674 (UMLS CUI [4])
C0022658 (UMLS CUI [5])
C0005686 (UMLS CUI [6])
C3843040 (UMLS CUI [7,1])
C0205404 (UMLS CUI [7,2])
Surgical Clips | Prosthesis Metallic | Replacement Body part | Hip joint replacement | Artificial cardiac pacemaker | Shrapnel | File Metallic
Item
t1dm patients and healthy volunteers will be expected to tell the researchers if they have surgical clips or metallic prostheses (i.e., replacement body parts, such as a hip joint) or a pacemaker or other pieces of metal in the body (shrapnel, metal filings, etc.).
boolean
C0038917 (UMLS CUI [1])
C0175649 (UMLS CUI [2,1])
C2986473 (UMLS CUI [2,2])
C0559956 (UMLS CUI [3,1])
C0229962 (UMLS CUI [3,2])
C0850128 (UMLS CUI [4])
C0030163 (UMLS CUI [5])
C0522670 (UMLS CUI [6])
C0180853 (UMLS CUI [7,1])
C2986473 (UMLS CUI [7,2])
Alcoholic Intoxication, Chronic | Alcohol consumption Significant
Item
patients with history of alcoholism or significant alcohol consumption will be excluded from the study.
boolean
C0001973 (UMLS CUI [1])
C0001948 (UMLS CUI [2,1])
C0750502 (UMLS CUI [2,2])
Lacking Able to speak English Language
Item
the consent form will be english, and non-english speakers will therefore be excluded from the study.
boolean
C0332268 (UMLS CUI [1,1])
C0564215 (UMLS CUI [1,2])
C0376245 (UMLS CUI [1,3])
Pregnancy | Cause 18f-fallypride Hazardous Substance
Item
pregnant women are excluded because 18f-fallypride is a radioactive substance , which will be injected into the patient and could be hazardous to the fetus.
boolean
C0032961 (UMLS CUI [1])
C0015127 (UMLS CUI [2,1])
C0300404 (UMLS CUI [2,2])
C0018626 (UMLS CUI [2,3])