Able to communicate Research Personnel | Informed Consent
Item
1. subjects must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent.
boolean
C2364293 (UMLS CUI [1,1])
C0035173 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2])
Age Study Protocol | Gender Breast Feeding Absent | Gender Pregnancy test negative
Item
2. subjects may be of either sex with age as described in each protocol. female subjects must be non-lactating and will be eligible only if they have a negative pregnancy test throughout the study period.
boolean
C0001779 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2,1])
C0006147 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
C0079399 (UMLS CUI [3,1])
C0427780 (UMLS CUI [3,2])
Age
Item
3. subjects must range in age from 18-65.
boolean
C0001779 (UMLS CUI [1])
Laboratory Results
Item
4. subjects must have the following laboratory values:
boolean
C1254595 (UMLS CUI [1])
Plasma Glucose Measurement OGTT
Item
2-hour ogtt plasma glucose 140-250 mg/dl
boolean
C0202042 (UMLS CUI [1,1])
C0029161 (UMLS CUI [1,2])
Hematocrit level
Item
hematocrit ≥ 35 vol%
boolean
C0518014 (UMLS CUI [1])
Creatinine measurement, serum
Item
serum creatinine ≤ 1.6 mg/dl
boolean
C0201976 (UMLS CUI [1])
Aspartate aminotransferase measurement
Item
ast (sgot) < 2.5 times upper limit of normal
boolean
C0201899 (UMLS CUI [1])
Alanine aminotransferase measurement
Item
alt (sgpt) < 2.5 times upper limit of normal
boolean
C0201836 (UMLS CUI [1])
Prothrombin time normal | Partial Thromboplastin Time measurement Normal
Item
pt, ptt within the normal range
boolean
C0580551 (UMLS CUI [1])
C0030605 (UMLS CUI [2,1])
C0205307 (UMLS CUI [2,2])
Pharmaceutical Preparations Effect Glucose tolerance | Glucocorticoids, Systemic | Estrogens Dose Stable allowed | Hormone replacement therapy Dose Stable allowed
Item
1. subjects must not be receiving any medications with known effects on glucose tolerance unless the subject has been on stable dose of such agents for the past three months before entry into the study. subjects taking systemic glucocorticoids will be excluded. subjects may be taking a stable dose of estrogens or other hormonal replacement therapy, if the subject has been on these agents for the prior three months.
boolean
C0013227 (UMLS CUI [1,1])
C1280500 (UMLS CUI [1,2])
C0178665 (UMLS CUI [1,3])
C3540777 (UMLS CUI [2])
C0014939 (UMLS CUI [3,1])
C0178602 (UMLS CUI [3,2])
C0205360 (UMLS CUI [3,3])
C0683607 (UMLS CUI [3,4])
C0282402 (UMLS CUI [4,1])
C0178602 (UMLS CUI [4,2])
C0205360 (UMLS CUI [4,3])
C0683607 (UMLS CUI [4,4])
Heart Disease | Myocardial Ischemia New York Heart Association Classification | Myocardial Ischemia More Than ECG Nonspecific ST-T change | Congestive heart failure
Item
2. history of clinically significant heart disease, including ischemic heart disease (new york heart classification greater than grade ii; more than non-specific st-t wave changes on the ekg) and congestive heart failure
boolean
C0018799 (UMLS CUI [1])
C0151744 (UMLS CUI [2,1])
C1275491 (UMLS CUI [2,2])
C0151744 (UMLS CUI [3,1])
C0439093 (UMLS CUI [3,2])
C1112720 (UMLS CUI [3,3])
C0018802 (UMLS CUI [4])
Peripheral Vascular Disease | Claudication
Item
3. history of peripheral vascular disease (history of claudication)
boolean
C0085096 (UMLS CUI [1])
C1456822 (UMLS CUI [2])
Lung disease | Dyspnea on exertion | Abnormal breath sounds Auscultation
Item
4. history of pulmonary disease (dyspnea on exertion of one flight or less; abnormal breath sounds on auscultation).
boolean
C0024115 (UMLS CUI [1])
C0231807 (UMLS CUI [2])
C0231856 (UMLS CUI [3,1])
C0004339 (UMLS CUI [3,2])
Peripheral edema
Item
5. history of peripheral edema
boolean
C0085649 (UMLS CUI [1])
Uncontrolled hypertension | Systolic Pressure | Diastolic blood pressure
Item
6. uncontrolled hypertension with systolic bp>160 mmhg, diastolic bp>100 mmhg
boolean
C1868885 (UMLS CUI [1])
C0871470 (UMLS CUI [2])
C0428883 (UMLS CUI [3])
Resting heart rate
Item
7. resting heart rate >100 beats/min
boolean
C1821417 (UMLS CUI [1])
Autonomic neuropathy
Item
8. autonomic neuropathy
boolean
C0259749 (UMLS CUI [1])
Heavy drinker Alcoholic drinks per day
Item
9. heavy alcohol consumption (> 2 drinks/day)
boolean
C0337678 (UMLS CUI [1,1])
C0001967 (UMLS CUI [1,2])
C0439505 (UMLS CUI [1,3])