Age | Non-Insulin-Dependent Diabetes Mellitus Disease length
Item
1. male or female, aged > 25 years and had been diagnosed as type 2 diabetes for at least 3 months before study entry.
boolean
C0001779 (UMLS CUI [1])
C0011860 (UMLS CUI [2,1])
C0872146 (UMLS CUI [2,2])
Sulfonylurea | Metformin
Item
2. subjects have taken sulfonylurea plus metformin therapy for at least 3 months before study entry.
boolean
C0038766 (UMLS CUI [1])
C0025598 (UMLS CUI [2])
Metformin Dose U/day | Sulfonylurea | Glimepiride Dose | Gliclazide Dose | Glipizide Dose | Glyburide Dose
Item
3. subjects have to take daily metformin 500~2000mg tolerable dosages and sulfonylurea (such as the usage dose of glimepiride ≧4mg; dose of gliclazide≧160mg; dose of glipizide ≧20mg; dose of glyburide≧4mg) for at least 1 months.
boolean
C0025598 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0456683 (UMLS CUI [1,3])
C0038766 (UMLS CUI [2])
C0061323 (UMLS CUI [3,1])
C0178602 (UMLS CUI [3,2])
C0017631 (UMLS CUI [4,1])
C0178602 (UMLS CUI [4,2])
C0017642 (UMLS CUI [5,1])
C0178602 (UMLS CUI [5,2])
C0017628 (UMLS CUI [6,1])
C0178602 (UMLS CUI [6,2])
Hemoglobin A1c measurement
Item
4. those subjects with hba1c historical levels between 7.0% and 11.0% within 3 month prior to study entry.
boolean
C0474680 (UMLS CUI [1])
Body mass index
Item
5. bmi between 20-35 kg /m2.
boolean
C1305855 (UMLS CUI [1])
Protocol Compliance | Informed Consent
Item
6. each subject must have a level of understanding sufficient to agree to all tests and examinations required by the protocol and must sign an informed consent document.
boolean
C0525058 (UMLS CUI [1])
C0021430 (UMLS CUI [2])
Dietary control Stable
Item
7. subjects have been under stable diet control for at least 1 month before study entry.
boolean
C0743195 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
Treatment Adherence | Diet | Sulfonylurea | Metformin
Item
8. subjects are willing to stick to current diet and sulfonylurea plus metformin treatment plan during this trial.
boolean
C4505265 (UMLS CUI [1])
C0012159 (UMLS CUI [2])
C0038766 (UMLS CUI [3])
C0025598 (UMLS CUI [4])
Pregnancy | Breast Feeding
Item
1. pregnant women or lactating mothers.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Diabetes Mellitus, Insulin-Dependent | Diabetes Mellitus caused by Pancreas damage | Secondary diabetes mellitus | Cushing Syndrome | Acromegaly
Item
2. type 1 dm(iddm), or diabetes caused by pancreas damage、secondary forms of diabetes, i.e., cushing's syndrome or acromegaly.
boolean
C0011854 (UMLS CUI [1])
C0011849 (UMLS CUI [2,1])
C0015127 (UMLS CUI [2,2])
C0030274 (UMLS CUI [2,3])
C0010957 (UMLS CUI [2,4])
C0271640 (UMLS CUI [3])
C0010481 (UMLS CUI [4])
C0001206 (UMLS CUI [5])
Complication Metabolic | Ketoacidosis | Hyperosmolar state | Coma
Item
3. a history of acute metabolic complication within 3 months before study entry, i.e., ketoacidosis or hyperosmolar state (coma).
boolean
C0009566 (UMLS CUI [1,1])
C0311400 (UMLS CUI [1,2])
C0220982 (UMLS CUI [2])
C0236013 (UMLS CUI [3])
C0009421 (UMLS CUI [4])
Complication Macrovascular | Angina, Unstable | Myocardial Infarction | Renal Insufficiency | Creatinine measurement, serum
Item
4. there are significant macrovascular complications (i.e. unstable angina or acute myocardial infarction) or renal impairment (serum creatinine higher than 1.5 mg/dl).
boolean
C0009566 (UMLS CUI [1,1])
C2609253 (UMLS CUI [1,2])
C0002965 (UMLS CUI [2])
C0027051 (UMLS CUI [3])
C1565489 (UMLS CUI [4])
C0201976 (UMLS CUI [5])
Hypersensitivity Pioglitazone
Item
5. have a known allergy to pioglitazone.
boolean
C0020517 (UMLS CUI [1,1])
C0071097 (UMLS CUI [1,2])
Pharmaceutical Preparations Interfere with Evaluation | Antidiabetics Oral | Adrenal Cortex Hormones
Item
6. other medications can be taken if their use had been instituted before study entry, but agents that can interfere with study evaluations, including other oral antidiabetic agents and corticosteroids, were not allowed.
boolean
C0013227 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C1261322 (UMLS CUI [1,3])
C0935929 (UMLS CUI [2,1])
C1527415 (UMLS CUI [2,2])
C0001617 (UMLS CUI [3])