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Anaphylactic reaction following the administration of vaccines (1)

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Known hypersensitivity to any component of the vaccine, or to subjects having shown signs of hypersensitivity after previous administration of diphtheria, tetanus, pertussis or HB vaccines (2)

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Encephalopathy (not due to another identifiably cause): acute, severe central nervous system disorder occurring within 7 days following vaccination, and generally consisting of major alterations in consciousness, unresponsiveness, generalized or focal seizures that persist more than a few hours, with failure to recover within 24 hours. Even though causation by DTP vaccine cannot be established, no subsequent doses of pertussis vaccine should be given. In these circumstances the vaccination course should be continued with DT and HB vaccines (3)

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Hypersensitivity reaction due to the vaccine (1)

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Intussusception (2)

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Acute illness accompanied by fever (t°>=38.0°C) or systemic manifestations. Evidence of minor disease with t° rise <38.0°C (upper respiratory tract infections or diarrhea) is not considered contraindication, and the dose should be given later. (1)

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Immunodeficiency, neoplasms and hematologic malignancies. Immunization should be deferred for 12 months after the completion of immunosuppressive, hormonal, or radiation therapy. (2)

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Nervous system disorders associated with the previous poliomyelitis vaccine administration. (3)

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Acute disease at the time of vaccioation: the presence of a moderate or severe illness with or without fever. All vaccines can be administered to persons with a minor illness such as diarrhoea, mild upper respiratory infection with or without low-grade febrile illness, i.e axillary t° <37.5°C/rectal t° >= 38°C (1)

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axillary t° >=37.5°C/rectal t° >= 38°C (2)

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Axillary t° >=37.5°C/ rectal t° >=38°C (1)

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Gastroenteritis within 7 days preceding the study vaccine administration (2)

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Fever >=40°C (axillary temperature) within 48 hours of vaccination not due to another identifiably cause (1)

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Collapse or shock-like state (hypotonic-hyposensitive episode) within 48 hours of vaccination (2)

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Persistent, inconsolable crying lasting >=3 hours occuring within 48 hours of vaccination (3)

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Seizures with or without fever occurring within 3 days of vaccination (4)