Diabetes Mellitus, Non-Insulin-Dependent | Poor glycemic control | Hemoglobin A1c measurement
Item
type 2 diabetes and inadequate glycemic control, defined as a1c ≥ 6.6 and ≤ 9.5%
boolean
C0011860 (UMLS CUI [1])
C0342299 (UMLS CUI [2])
C0474680 (UMLS CUI [3])
Metformin Dose Stable | Sulfonylurea Dose Stable
Item
stable dose of metformin and/or a sulfonylurea, for at least 4 weeks prior to the enrollment visit
boolean
C0025598 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
C0038766 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0205360 (UMLS CUI [2,3])
Control of blood pressure Inadequate | Systolic Pressure | Diastolic blood pressure
Item
inadequate blood pressure (bp) control, defined as systolic bp (sbp) ≥ 130 and < 165 mmhg, and/or diastolic bp (dbp) ≥ 80 and < 105 mmhg
boolean
C1753303 (UMLS CUI [1,1])
C0205412 (UMLS CUI [1,2])
C0871470 (UMLS CUI [2])
C0428883 (UMLS CUI [3])
C-peptide measurement
Item
c-peptide ≥ 0.8 ng/ml
boolean
C0202100 (UMLS CUI [1])
GFR estimation by MDRD
Item
estimated gfr by the modification of diet in renal disease (mdrd) formula > 60 ml/min/1.73m² and < 150 ml/min/1.73m²
boolean
C2170215 (UMLS CUI [1])
Urine albumin/creatinine ratio measurement
Item
urine albumin:creatinine ratio (uacr) < 300 mg/g
boolean
C0455271 (UMLS CUI [1])
Body mass index
Item
bmi ≤ 45.0 kg/m2
boolean
C1305855 (UMLS CUI [1])
Diuretics | Antihypertensive Agents | Exception Angiotensin-Converting Enzyme Inhibitors | Exception Angiotensin II receptor antagonist
Item
administration of diuretics or other medication approved for the treatment of hypertension (with the exception of either acei or arb), at any dose during the 12 weeks prior to the enrollment visit
boolean
C0012798 (UMLS CUI [1])
C0003364 (UMLS CUI [2])
C1705847 (UMLS CUI [3,1])
C0003015 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0521942 (UMLS CUI [4,2])
Adverse reaction Contrast dye
Item
history of adverse reaction to radio-contrast dye
boolean
C0559546 (UMLS CUI [1,1])
C0742795 (UMLS CUI [1,2])
Hypersensitivity Thiazide Diuretics | Medical contraindication Thiazide Diuretics
Item
allergy or contraindication to use of thiazide diuretics
boolean
C0020517 (UMLS CUI [1,1])
C0012802 (UMLS CUI [1,2])
C1301624 (UMLS CUI [2,1])
C0012802 (UMLS CUI [2,2])
Aspartate aminotransferase increased
Item
aspartate aminotransferase (ast) > 3x upper limit of normal (uln)
boolean
C0151904 (UMLS CUI [1])
Alanine aminotransferase increased
Item
alanine aminotransferase (alt) > 3x uln
boolean
C0151905 (UMLS CUI [1])
SERUM TOTAL BILIRUBIN ELEVATED
Item
serum total bilirubin > 1.5x uln
boolean
C0595866 (UMLS CUI [1])
Creatinine measurement, serum | Gender
Item
serum creatinine (scr) ≥ 1.50 mg/dl (133 μmol/l) for men; scr ≥ 1.40 mg/dl (124
boolean
C0201976 (UMLS CUI [1])
C0079399 (UMLS CUI [2])
ID.15
Item
μmol/l) for women
boolean
Cardiovascular Diseases Unstable | Kidney Diseases Unstable | Liver diseases Unstable | Hematological Disease Unstable | Malignant disease Unstable | Endocrine System Diseases Unstable | Mental disorders Unstable | Rheumatism Unstable | Cardiovascular Diseases Serious | Kidney Diseases Serious | Liver diseases Serious | Hematological Disease Serious | Malignant disease Serious | Endocrine System Diseases Serious | Mental disorders Serious | Rheumatism Serious
Item
currently unstable or serious cardiovascular, renal, hepatic, hematological, oncologic, endocrine, psychiatric, or rheumatic diseases
boolean
C0007222 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
C0022658 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0023895 (UMLS CUI [3,1])
C0443343 (UMLS CUI [3,2])
C0018939 (UMLS CUI [4,1])
C0443343 (UMLS CUI [4,2])
C0442867 (UMLS CUI [5,1])
C0443343 (UMLS CUI [5,2])
C0014130 (UMLS CUI [6,1])
C0443343 (UMLS CUI [6,2])
C0004936 (UMLS CUI [7,1])
C0443343 (UMLS CUI [7,2])
C0035435 (UMLS CUI [8,1])
C0443343 (UMLS CUI [8,2])
C0007222 (UMLS CUI [9,1])
C0205404 (UMLS CUI [9,2])
C0022658 (UMLS CUI [10,1])
C0205404 (UMLS CUI [10,2])
C0023895 (UMLS CUI [11,1])
C0205404 (UMLS CUI [11,2])
C0018939 (UMLS CUI [12,1])
C0205404 (UMLS CUI [12,2])
C0442867 (UMLS CUI [13,1])
C0205404 (UMLS CUI [13,2])
C0014130 (UMLS CUI [14,1])
C0205404 (UMLS CUI [14,2])
C0004936 (UMLS CUI [15,1])
C0205404 (UMLS CUI [15,2])
C0035435 (UMLS CUI [16,1])
C0205404 (UMLS CUI [16,2])