Age
Item
participant is between 18 and 55 years of age. participants up to 65 years of age may be enrolled in panels b and c
boolean
C0001779 (UMLS CUI [1])
Postmenopausal state | Female infertility
Item
female participants must be postmenopausal or otherwise unable to have children
boolean
C0232970 (UMLS CUI [1])
C0021361 (UMLS CUI [2])
Body mass index
Item
participant has a body mass index (bmi) less than or equal to 42 kg/m^2 at the screening visit
boolean
C1305855 (UMLS CUI [1])
Diabetes Mellitus, Non-Insulin-Dependent | Diet therapy | Exercise | Oral hypoglycemic Single | Oral hypoglycemic Combined Modality Therapy
Item
participant has type 2 diabetes and is being treated with either diet and exercise or a single oral anti-hyperglycemic medication. for panels b and c, participant may be treated with combination oral anti-hyperglycemic medications
boolean
C0011860 (UMLS CUI [1])
C0012159 (UMLS CUI [2])
C0015259 (UMLS CUI [3])
C0359086 (UMLS CUI [4,1])
C0205171 (UMLS CUI [4,2])
C0359086 (UMLS CUI [5,1])
C0009429 (UMLS CUI [5,2])
Adherence Diet therapy American Heart Association | Adherence Exercise American Heart Association
Item
participant is willing to follow the american heart association (aha) diet and exercise program throughout the study
boolean
C1510802 (UMLS CUI [1,1])
C0012159 (UMLS CUI [1,2])
C0002458 (UMLS CUI [1,3])
C1510802 (UMLS CUI [2,1])
C0015259 (UMLS CUI [2,2])
C0002458 (UMLS CUI [2,3])
Non-smoker | Tobacco use Absent Duration
Item
participant is a nonsmoker or has not used nicotine-containing products for 6 months prior to study start
boolean
C0337672 (UMLS CUI [1])
C0543414 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0449238 (UMLS CUI [2,3])
Cerebrovascular accident | Seizures | Nervous system disorder
Item
participant has a history of stroke, seizures, or other neurological disorders
boolean
C0038454 (UMLS CUI [1])
C0036572 (UMLS CUI [2])
C0027765 (UMLS CUI [3])
Eye Infection | Inflammatory abnormality of the eye
Item
participant has a recent history of eye infection or other inflammatory eye conditions
boolean
C0015403 (UMLS CUI [1])
C4020969 (UMLS CUI [2])
Glaucoma | Blindness
Item
participant has glaucoma or is blind
boolean
C0017601 (UMLS CUI [1])
C0456909 (UMLS CUI [2])
Ophthalmologic Surgical Procedures | LASIK allowed
Item
participant has had eye surgery within 6 months of study start (lasik is permitted)
boolean
C0038901 (UMLS CUI [1])
C0752094 (UMLS CUI [2,1])
C0683607 (UMLS CUI [2,2])
Diabetes Mellitus, Insulin-Dependent
Item
participant has type 1 diabetes
boolean
C0011854 (UMLS CUI [1])
Pharmaceutical Preparations Unable to discontinue | Non-Prescription Drugs Unable to discontinue
Item
participant cannot stop taking any of their current prescription or non-prescription medications during the study
boolean
C0013227 (UMLS CUI [1,1])
C1548265 (UMLS CUI [1,2])
C0013231 (UMLS CUI [2,1])
C1548265 (UMLS CUI [2,2])
Consumption Alcoholic Beverages U/day
Item
participant consumes more than 3 alcoholic beverages per day
boolean
C0001948 (UMLS CUI [1,1])
C0001967 (UMLS CUI [1,2])
C0456683 (UMLS CUI [1,3])
Consumption Caffeinated beverage U/day
Item
participant consumes more than 6 caffeinated beverages per day
boolean
C0948365 (UMLS CUI [1,1])
C0678438 (UMLS CUI [1,2])
C0456683 (UMLS CUI [1,3])
Major surgery | Blood Donation
Item
participant has had major surgery or has donated blood within 4 weeks of study start
boolean
C0679637 (UMLS CUI [1])
C0005794 (UMLS CUI [2])
DRUG ALLERGY MULTIPLE | Drug Allergy Severe | FOOD ALLERGY TO MULTIPLE FOOD | Food Allergy Severe
Item
participant has multiple and/or severe allergies to drugs or food
boolean
C0743280 (UMLS CUI [1])
C0013182 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0744084 (UMLS CUI [3])
C0016470 (UMLS CUI [4,1])
C0205082 (UMLS CUI [4,2])