Age
Item
aged 18 years or older
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status 0-2
boolean
C1520224 (UMLS CUI [1])
Invasive carcinoma of breast
Item
histologically confirmed diagnosis of invasive breast carcinoma
boolean
C0853879 (UMLS CUI [1])
HER2 Overexpression Immunohistochemistry | HER2 Overexpression FISH | HER2 Overexpression In Situ Hybridization Dual
Item
histologically confirmed her2 overexpression using ihc and/or fish and/or dish
boolean
C0069515 (UMLS CUI [1,1])
C1514559 (UMLS CUI [1,2])
C0021044 (UMLS CUI [1,3])
C0069515 (UMLS CUI [2,1])
C1514559 (UMLS CUI [2,2])
C0162789 (UMLS CUI [2,3])
C0069515 (UMLS CUI [3,1])
C1514559 (UMLS CUI [3,2])
C0162788 (UMLS CUI [3,3])
C0205173 (UMLS CUI [3,4])
Trastuzumab Planned | T-DM1 Planned
Item
planned treatment with trastuzumab or tdm-1
boolean
C0728747 (UMLS CUI [1,1])
C1301732 (UMLS CUI [1,2])
C2935436 (UMLS CUI [2,1])
C1301732 (UMLS CUI [2,2])
LVEF MUGA scan | LVEF Echocardiography
Item
baseline lvef >50% by muga (echos or any other type of cardiac scanning may be done as part of standard clinical care, at the investigator's discretion; echos cannot be done in place of muga scans)
boolean
C0428772 (UMLS CUI [1,1])
C0521317 (UMLS CUI [1,2])
C0428772 (UMLS CUI [2,1])
C0013516 (UMLS CUI [2,2])
Trastuzumab Prior Therapy | HER2 Inhibitor Prior Therapy | lapatinib | pertuzumab
Item
previous treatment with trastuzumab or any other anti-her2 agent (e.g. lapatinib, pertuzumab, etc.)
boolean
C0728747 (UMLS CUI [1,1])
C1514463 (UMLS CUI [1,2])
C0069515 (UMLS CUI [2,1])
C1999216 (UMLS CUI [2,2])
C1514463 (UMLS CUI [2,3])
C1506770 (UMLS CUI [3])
C1328025 (UMLS CUI [4])
Heart failure Symptomatic Pre-existing New York Heart Association Classification
Item
pre-existing symptomatic heart failure (nyha class iii or iv)
boolean
C0018801 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C2347662 (UMLS CUI [1,3])
C1275491 (UMLS CUI [1,4])
Acute Coronary Syndrome | Myocardial Infarction | Angina, Unstable
Item
recent acute coronary syndrome (myocardial infarction, unstable angina) within the last six months
boolean
C0948089 (UMLS CUI [1])
C0027051 (UMLS CUI [2])
C0002965 (UMLS CUI [3])
Coronary revascularisation | Percutaneous Coronary Intervention | Coronary Artery Bypass Surgery
Item
recent coronary revascularization (percutaneous coronary intervention or coronary bypass surgery) within six months
boolean
C0877341 (UMLS CUI [1])
C1532338 (UMLS CUI [2])
C0010055 (UMLS CUI [3])
Permanent atrial fibrillation
Item
permanent atrial fibrillation
boolean
C2586056 (UMLS CUI [1])
MRI Receive Unable | Shrapnel | Metallic implant | Clip | Artificial cardiac pacemaker | Defibrillators
Item
inability to undergo mri (shrapnel, metallic implants/clips, pacemaker or defibrillator)
boolean
C0024485 (UMLS CUI [1,1])
C1514756 (UMLS CUI [1,2])
C1299582 (UMLS CUI [1,3])
C0522670 (UMLS CUI [2])
C3693688 (UMLS CUI [3])
C0175722 (UMLS CUI [4])
C0030163 (UMLS CUI [5])
C0180307 (UMLS CUI [6])
Pregnancy | Breast Feeding
Item
currently pregnant and/or nursing
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Targeted Therapy biological Causing Cardiotoxicity | bevacizumab
Item
planned or current use of other targeted biological therapies that can potentially cause cardiotoxicity (i.e. bevacizumab)
boolean
C2985566 (UMLS CUI [1,1])
C0205460 (UMLS CUI [1,2])
C0678227 (UMLS CUI [1,3])
C0876994 (UMLS CUI [1,4])
C0796392 (UMLS CUI [2])