Parkinson Disease
Item
1. patients with idiopathic parkinson's disease, according to the uk brain bank criteria.
boolean
C0030567 (UMLS CUI [1])
Drooling | Sialorrhea Rating scale
Item
2. patients complaining of drooling, with a score of at least 3 in the fleni sialorrhea scale.
boolean
C0013132 (UMLS CUI [1])
C0037036 (UMLS CUI [2,1])
C0681889 (UMLS CUI [2,2])
Age
Item
3. patient is between 50 and 80 years of age, inclusive.
boolean
C0001779 (UMLS CUI [1])
Gender | Gender Pregnancy Absent | Childbearing Potential Pregnancy test negative | Childbearing Potential Contraceptive methods
Item
4. male or non-pregnant female. females of child-bearing potential will be required to have undergone a pregnancy test with negative results prior to entry to the study and agree to use contraceptive measures for the duration of the study.
boolean
C0079399 (UMLS CUI [1])
C0079399 (UMLS CUI [2,1])
C0032961 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
C3831118 (UMLS CUI [3,1])
C0427780 (UMLS CUI [3,2])
C3831118 (UMLS CUI [4,1])
C0700589 (UMLS CUI [4,2])
Pharmaceutical Preparations Same Parkinson Disease | Pharmaceutical Preparations Dosage Same Parkinson Disease
Item
5. patients must have used the same medication and dose for pd for the last month. no changes in the medication for pd are expected during the study.
boolean
C0013227 (UMLS CUI [1,1])
C0445247 (UMLS CUI [1,2])
C0030567 (UMLS CUI [1,3])
C0013227 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0445247 (UMLS CUI [2,3])
C0030567 (UMLS CUI [2,4])
Patient state | Testing
Item
6. patients who can reasonable be expected to be on "on-state" for the duration of the testing procedures.
boolean
C0683521 (UMLS CUI [1])
C0039593 (UMLS CUI [2])
Levodopa Parkinson Disease | Response Stable
Item
7. patients who have a stable response to levodopa for pd.
boolean
C0023570 (UMLS CUI [1,1])
C0030567 (UMLS CUI [1,2])
C1704632 (UMLS CUI [2,1])
C0205360 (UMLS CUI [2,2])
Pregnancy | Pregnancy possible
Item
1. pregnant women or women who may become pregnant.
boolean
C0032961 (UMLS CUI [1])
C0425965 (UMLS CUI [2])
Depressive disorder | Schizophrenia | Symptoms Depressive disorder | Symptoms Schizophrenia
Item
2. patients with a diagnosis of depression, schizophrenia or with obvious symptoms of these diseases.
boolean
C0011581 (UMLS CUI [1])
C0036341 (UMLS CUI [2])
C1457887 (UMLS CUI [3,1])
C0011581 (UMLS CUI [3,2])
C1457887 (UMLS CUI [4,1])
C0036341 (UMLS CUI [4,2])
Mini-mental state examination
Item
3. patients with mmse score equal to or lower than 26.
boolean
C0451306 (UMLS CUI [1])
Tricyclic Antidepressive Agents | Monoamine Oxidase Inhibitors | Antipsychotic Agents | Anticholinergic Agents
Item
4. patients who are receiving the following drugs: tricyclic antidepressants, maoi's, neuroleptics (antipsychotics), or anticholinergics.
boolean
C0003290 (UMLS CUI [1])
C0026457 (UMLS CUI [2])
C0040615 (UMLS CUI [3])
C0242896 (UMLS CUI [4])
Pharmaceutical Preparations Excluded
Item
5. patients who have taken any of the drugs mentioned in exclusion criteria number 4 within the last week.
boolean
C0013227 (UMLS CUI [1,1])
C0332196 (UMLS CUI [1,2])
Atropine allergy | Anticholinergic allergy
Item
6. patients with hypersensitivity to atropine or other anticholinergic drugs.
boolean
C0570993 (UMLS CUI [1])
C0570982 (UMLS CUI [2])
Adverse effects Due to Anticholinergic Agents
Item
7. patients who have experienced adverse effects as a result of taking anticholinergic drugs.
boolean
C0879626 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0242896 (UMLS CUI [1,3])
Hypnotics | Sleep Inducing Drugs
Item
8. patients taking hypnotic or other sleep inducing drugs.
boolean
C0020591 (UMLS CUI [1])
C0871377 (UMLS CUI [2])
Urinary symptoms Severe | Gastrointestinal symptoms Severe
Item
9. patients with severe urinary or gastrointestinal symptoms.
boolean
C0426359 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0426576 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
Dental Diseases | Mouth Diseases
Item
10. patients with significant dental/oral pathology.
boolean
C1704330 (UMLS CUI [1])
C0026636 (UMLS CUI [2])
Dysautonomia Severe
Item
11. patients with severe dysautonomia.
boolean
C0013363 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])