Inpatient | Schizophrenia
Item
1. inpatients meet the dsm-iv criteria for schizophrenia.
boolean
C0021562 (UMLS CUI [1])
C0036341 (UMLS CUI [2])
Unresponsive to Treatment | Antipsychotic Agents Quantity failed | Dosage Equivalent Chlorpromazine U/day | Dosage Greater Than Chlorpromazine U/day
Item
2. treatment refractoriness: failed to respond to at least two typical neuroleptics at dosage equivalent to or greater than 1000 mg/day of chlorpromazine for a period of at least six weeks.
boolean
C0205269 (UMLS CUI [1])
C0040615 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0231175 (UMLS CUI [2,3])
C0178602 (UMLS CUI [3,1])
C0205163 (UMLS CUI [3,2])
C0008286 (UMLS CUI [3,3])
C0456683 (UMLS CUI [3,4])
C0178602 (UMLS CUI [4,1])
C0439093 (UMLS CUI [4,2])
C0008286 (UMLS CUI [4,3])
C0456683 (UMLS CUI [4,4])
Age
Item
3. age 18-60 years.
boolean
C0001779 (UMLS CUI [1])
Gender
Item
4. males or females.
boolean
C0079399 (UMLS CUI [1])
PANSS
Item
5. total panss score >60
boolean
C4086747 (UMLS CUI [1])
Physical Well-being Complete physical examination | Physical Well-being Laboratory Procedures | Physical Well-being EKG
Item
6. good physical health determined by complete physical examination, laboratory tests, and ekg.
boolean
C0517226 (UMLS CUI [1,1])
C0436120 (UMLS CUI [1,2])
C0517226 (UMLS CUI [2,1])
C0022885 (UMLS CUI [2,2])
C0517226 (UMLS CUI [3,1])
C0013798 (UMLS CUI [3,2])
Informed Consent
Item
7. capacity and willingness to give written informed consent.
boolean
C0021430 (UMLS CUI [1])
Substance Use Disorders Illicit Substance | Substance Dependence Illicit Substance
Item
1. history of illicit substance abuse or dependence
boolean
C0038586 (UMLS CUI [1,1])
C2697662 (UMLS CUI [1,2])
C0038580 (UMLS CUI [2,1])
C2697662 (UMLS CUI [2,2])
Intolerance to Clozapine | Leukopenia | Agranulocytosis
Item
2. history of clozapine intolerance (such as clinically significant leukopenia or agranulocytosis).
boolean
C1744706 (UMLS CUI [1,1])
C0009079 (UMLS CUI [1,2])
C0023530 (UMLS CUI [2])
C0001824 (UMLS CUI [3])
White Blood Cell Count procedure | Absolute neutrophil count
Item
3. patients with wbc count less than 3500/mm3 or anc count less than 2000/mm3will not be included.
boolean
C0023508 (UMLS CUI [1])
C0948762 (UMLS CUI [2])
Injection of depot antipsychotic agent
Item
4. any depot neuroleptics within 30 days before the day of randomization.
boolean
C2585377 (UMLS CUI [1])
Epilepsy | Hepatitis | HIV Seropositivity | Myeloproliferative disease | Illness Study Subject Participation Status Exclusion | Status post Patient evaluation
Item
5. epilepsy, active hepatitis, hiv positivity, or current myeloproliferative disorder. other medical illnesses may necessitate subjects' exclusion after evaluation of individual cases by the principal investigator and other staffs. clinical judgment will be used.
boolean
C0014544 (UMLS CUI [1])
C0019158 (UMLS CUI [2])
C0019699 (UMLS CUI [3])
C0027022 (UMLS CUI [4])
C0221423 (UMLS CUI [5,1])
C2348568 (UMLS CUI [5,2])
C2828389 (UMLS CUI [5,3])
C0231290 (UMLS CUI [6,1])
C0679830 (UMLS CUI [6,2])