Age
Item
1. age 18-60 years, male or female
boolean
C0001779 (UMLS CUI [1])
Schizophrenia | Schizoaffective Disorder
Item
2. dsm-iv criteria for schizophrenia, or schizoaffective disorder.
boolean
C0036341 (UMLS CUI [1])
C0036337 (UMLS CUI [2])
Informed Consent
Item
3. ability and willingness to sign informed consent for participation in the study
boolean
C0021430 (UMLS CUI [1])
Blood parameters Stable | Hematologic function | White Blood Cell Count procedure
Item
4. stable blood parameters including adequate hematologic function, defined as wbc ≥
boolean
C0005767 (UMLS CUI [1,1])
C0449381 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
C0221130 (UMLS CUI [2])
C0023508 (UMLS CUI [3])
Absolute neutrophil count | Platelet Count measurement
Item
4.300/μl, absolute neutrophil count ≥3.000/μl (> 50%), and platelet count ≥
boolean
C0948762 (UMLS CUI [1])
C0032181 (UMLS CUI [2])
Parameters Blood coagulation Normal | Serum total bilirubin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Creatinine measurement, serum
Item
180,000/μl; normal coagulation parameters; bilirubin ≤1.5 times the upper limit of normal (uln); ast/alt ≤ 2.5 × uln; and serum creatinine ≤1.5 mg/dl.
boolean
C0449381 (UMLS CUI [1,1])
C0005778 (UMLS CUI [1,2])
C0205307 (UMLS CUI [1,3])
C1278039 (UMLS CUI [2])
C0201899 (UMLS CUI [3])
C0201836 (UMLS CUI [4])
C0201976 (UMLS CUI [5])
Serum fasting triglyceride level result Normal | Normalization caused by Hypolipidemic Agents allowed
Item
5. only patients who had a normal baseline fasting triglyceride (ftg) level will be entered into the study; triglycerides may be normalized before study entry with use of an antilipemic agent.
boolean
C1318355 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
C1882115 (UMLS CUI [2,1])
C0015127 (UMLS CUI [2,2])
C0086440 (UMLS CUI [2,3])
C0683607 (UMLS CUI [2,4])
Lipids abnormal | Serum fasting triglyceride measurement Normal
Item
1. lipid abnormalities. fasting triglyceride normal (normalization with an antilipemic allowed prior to study entry).
boolean
C0549634 (UMLS CUI [1])
C0582824 (UMLS CUI [2,1])
C0205307 (UMLS CUI [2,2])
Leukopenia | Neutropenia | Parameters Hematopoietic | Hemoglobin measurement | White Blood Cell Count procedure | Absolute neutrophil count | Platelet Count measurement
Item
2. leucopenia or neutropenia. hematopoietic: hemoglobin at least 12.5 g/dl; wbc< 4300/μl; absolute neutrophil count < 3000/μl; platelet count < 155,000/μl
boolean
C0023530 (UMLS CUI [1])
C0027947 (UMLS CUI [2])
C0449381 (UMLS CUI [3,1])
C0229601 (UMLS CUI [3,2])
C0518015 (UMLS CUI [4])
C0023508 (UMLS CUI [5])
C0948762 (UMLS CUI [6])
C0032181 (UMLS CUI [7])
Organic brain disorder | Mental Retardation | Substance Use Disorders
Item
3. evidence of organic brain damage, mental retardation, alcohol or drug abuse
boolean
C4062280 (UMLS CUI [1])
C0025362 (UMLS CUI [2])
C0038586 (UMLS CUI [3])
Renal Insufficiency
Item
4. impairment of renal function
boolean
C1565489 (UMLS CUI [1])
Liver Dysfunction
Item
5. hepatic dysfunction
boolean
C0086565 (UMLS CUI [1])
Pancreatitis
Item
6. a history of pancreatitis
boolean
C0030305 (UMLS CUI [1])
Axis Thyroid Alteration
Item
7. thyroid axis alterations
boolean
C1522496 (UMLS CUI [1,1])
C0040132 (UMLS CUI [1,2])
C1515926 (UMLS CUI [1,3])
Suicide attempt
Item
8. suicide attempt in past year.
boolean
C0038663 (UMLS CUI [1])
Cataract
Item
9. cataracts.
boolean
C0086543 (UMLS CUI [1])
Systemic therapy Vitamin A U/day
Item
10. systemic treatment with more than 15,000 iu of vitamin a daily.
boolean
C1515119 (UMLS CUI [1,1])
C0042839 (UMLS CUI [1,2])
C0456683 (UMLS CUI [1,3])
Hypersensitivity Bexarotene | Hypersensitivity Component Bexarotene
Item
11. patients with a known hypersensitivity to bexarotene or other components of the product.
boolean
C0020517 (UMLS CUI [1,1])
C0765273 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C1705248 (UMLS CUI [2,2])
C0765273 (UMLS CUI [2,3])
Pregnancy | Pregnancy, Planned
Item
12. pregnant women or a woman who intends to become pregnant.
boolean
C0032961 (UMLS CUI [1])
C0032992 (UMLS CUI [2])