Sarcoidosis
Item
biopsy proven sarcoidosis
boolean
C0036202 (UMLS CUI [1])
Mean pulmonary arterial pressure At rest Catheterization of right heart | Mean pulmonary arterial pressure Exercise Catheterization of right heart
Item
mean pulmonary artery pressure > 25 mmhg at rest and greater than 30 mmhg with exercise by right heart catheterization within 1 year prior to entry into study
boolean
C3854605 (UMLS CUI [1,1])
C0443144 (UMLS CUI [1,2])
C0189896 (UMLS CUI [1,3])
C3854605 (UMLS CUI [2,1])
C0015259 (UMLS CUI [2,2])
C0189896 (UMLS CUI [2,3])
Pulmonary Capillary Wedge Pressure
Item
pulmonary capillary wedge pressure ≤ 15 mmhg
boolean
C0086879 (UMLS CUI [1])
Pulmonary Vascular Resistance Wood units
Item
pvr values >3.0 woods units
boolean
C0456261 (UMLS CUI [1,1])
C0439525 (UMLS CUI [1,2])
Forced Vital Capacity
Item
forced vital capacity (fvc) >40%
boolean
C3714541 (UMLS CUI [1])
WHO classification Functional Status Class
Item
who functional class ii or iii
boolean
C4267671 (UMLS CUI [1,1])
C0598463 (UMLS CUI [1,2])
C0456387 (UMLS CUI [1,3])
Therapy Stable Sarcoidosis
Item
stable sarcoidosis treatment regimen for three months prior to entry into study
boolean
C0087111 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
C0036202 (UMLS CUI [1,3])
6-Minute Walk Test Meter Quantity
Item
6 minute walk distance between 150-450 meters
boolean
C0430515 (UMLS CUI [1,1])
C0475209 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
Antihypertensive Agents Dose Stable
Item
stable dose of antihypertensive medications
boolean
C0003364 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
Absence Pharmaceutical Preparations Other Pulmonary arterial hypertension | sildenafil | tadalafil | vardenafil | Treprostinil | Epoprostenol | Iloprost | bosentan | sitaxsentan
Item
on no other medication to treat pah (sildenafil, tadalafil, vardenafil, treprostinil, epoprostenol, iloprost, bosentan, sitaxsentan) within one month prior to enrollment and during duration of the study
boolean
C0332197 (UMLS CUI [1,1])
C0013227 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C2973725 (UMLS CUI [1,4])
C0529793 (UMLS CUI [2])
C1176316 (UMLS CUI [3])
C0971579 (UMLS CUI [4])
C1145760 (UMLS CUI [5])
C0033567 (UMLS CUI [6])
C0079594 (UMLS CUI [7])
C0252643 (UMLS CUI [8])
C1704271 (UMLS CUI [9])
Gender | Pregnancy Absent
Item
non-pregnant females
boolean
C0079399 (UMLS CUI [1])
C0032961 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
Exercise Limited | Etiology Except Cardiopulmonary disease | Etiology Arthritis
Item
exercise limitation related to a non-cardiopulmonary reason (e.g. arthritis)
boolean
C0015259 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0015127 (UMLS CUI [2,1])
C0332300 (UMLS CUI [2,2])
C0034072 (UMLS CUI [2,3])
C0015127 (UMLS CUI [3,1])
C0003864 (UMLS CUI [3,2])
Systemic hypertension Severe
Item
severe systemic hypertension > 170/95
boolean
C0020538 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
Congestive heart failure | Ventricular Dysfunction, Left | Right Ventricular Dysfunction Primary
Item
patients with congestive heart failure (left ventricular dysfunction) or primary right ventricular dysfunction
boolean
C0018802 (UMLS CUI [1])
C0242698 (UMLS CUI [2])
C0242707 (UMLS CUI [3,1])
C0205225 (UMLS CUI [3,2])
Treatment escalation plan Sarcoidosis
Item
anticipation by the investigator for escalation in sarcoidosis treatment during the course of the study
boolean
C4543664 (UMLS CUI [1,1])
C0036202 (UMLS CUI [1,2])
Pulmonary Hypertension Relationship Etiology | Exception Sarcoidosis | HIV Infection | Scleroderma
Item
pulmonary hypertension related to etiology other than sarcoidosis (i.e. hiv, scleroderma, etc.)
boolean
C0020542 (UMLS CUI [1,1])
C0439849 (UMLS CUI [1,2])
C0015127 (UMLS CUI [1,3])
C1705847 (UMLS CUI [2,1])
C0036202 (UMLS CUI [2,2])
C0019693 (UMLS CUI [3])
C0011644 (UMLS CUI [4])
Endothelin receptor antagonist | bosentan | sitaxsentan
Item
use within 1 month of an endothelin receptor antagonists (bosentan, sitaxsentan).
boolean
C1134681 (UMLS CUI [1])
C0252643 (UMLS CUI [2])
C1704271 (UMLS CUI [3])
WHO classification Functional Status Class
Item
who functional class iv status
boolean
C4267671 (UMLS CUI [1,1])
C0598463 (UMLS CUI [1,2])
C0456387 (UMLS CUI [1,3])
Ventricular Dysfunction, Left
Item
patients with significant left ventricular dysfunction
boolean
C0242698 (UMLS CUI [1])
Liver Dysfunction | Relationship Absent Sarcoidosis
Item
significant liver dysfunction not due to sarcoidosis.
boolean
C0086565 (UMLS CUI [1])
C0439849 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0036202 (UMLS CUI [2,3])
Organic disease Severe Impact Survival
Item
patients with severe other organ disease felt by investigators to impact on survival during the course of the study.
boolean
C0683324 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C4049986 (UMLS CUI [1,3])
C0220921 (UMLS CUI [1,4])