Rheumatoid Arthritis Disease length
Item
must have a diagnosis of ra for at least 6 months
boolean
C0003873 (UMLS CUI [1,1])
C0872146 (UMLS CUI [1,2])
Methotrexate Dose Stable U/week
Item
must be taking methotrexate for at least 3 months & on a stable dose of 7.5-30 mg weekly) for 4 weeks before dosing with study medication
boolean
C0025677 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
C0560588 (UMLS CUI [1,4])
Swollen joint count | Tender joint count
Item
must have at least 6 swollen and at least 8 tender joints
boolean
C0451521 (UMLS CUI [1])
C0451530 (UMLS CUI [2])
Elevated C-reactive protein | Erythrocyte sedimentation rate measurement
Item
crp above upper limit of normal or esr > 28 mm/hr
boolean
C0742906 (UMLS CUI [1])
C1176468 (UMLS CUI [2])
Immunosuppressive Agents With Washout Period | Exception Methotrexate | Therapeutic procedure Rheumatoid Arthritis
Item
must wash-out (stop taking) other immunosuppressant medications to treat ra (except for methotrexate) before dosing with study medication
boolean
C0021081 (UMLS CUI [1,1])
C0332287 (UMLS CUI [1,2])
C1710661 (UMLS CUI [1,3])
C1705847 (UMLS CUI [2,1])
C0025677 (UMLS CUI [2,2])
C0087111 (UMLS CUI [3,1])
C0003873 (UMLS CUI [3,2])
Communicable Disease | Tuberculosis | HIV Infection | Hepatitis B | Hepatitis C
Item
any infection including tb, hiv, hepatitis b or c
boolean
C0009450 (UMLS CUI [1])
C0041296 (UMLS CUI [2])
C0019693 (UMLS CUI [3])
C0019163 (UMLS CUI [4])
C0019196 (UMLS CUI [5])
Communicable Disease Requirement Antibiotics
Item
recent infection requiring antibiotics within 4 weeks
boolean
C0009450 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0003232 (UMLS CUI [1,3])
Gastrointestinal Disease Treatment required for | Gastrointestinal Disease Requirement Operative Surgical Procedures | Gastroesophageal reflux disease | Gastrointestinal ulcer | Heartburn
Item
history of gastrointestinal disease (such as gerd, gastrointestinal ulcers, heartburn) requiring medical or surgical treatment within 3 months
boolean
C0017178 (UMLS CUI [1,1])
C0332121 (UMLS CUI [1,2])
C0017178 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0543467 (UMLS CUI [2,3])
C0017168 (UMLS CUI [3])
C0237938 (UMLS CUI [4])
C0018834 (UMLS CUI [5])
Proton Pump Inhibitors chronic | Losec | Prilosec | Prevacid | Nexium | H2 Antagonists chronic | Tagamet | Pepcid | Zantac | Axid | Antacids chronic | Mylanta | Maalox
Item
chronic use of proton pump inhibitors (such as losec, prilosec, prevacid, nexium), h2 blockers (such as tagamet, pepcid, zantac, axid) or antacids (such as mylanta, maalox)
boolean
C0358591 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
C0591742 (UMLS CUI [2])
C0700777 (UMLS CUI [3])
C0286036 (UMLS CUI [4])
C0939400 (UMLS CUI [5])
C0019593 (UMLS CUI [6,1])
C0205191 (UMLS CUI [6,2])
C0592157 (UMLS CUI [7])
C0678119 (UMLS CUI [8])
C0592278 (UMLS CUI [9])
C0678129 (UMLS CUI [10])
C0003138 (UMLS CUI [11,1])
C0205191 (UMLS CUI [11,2])
C0067044 (UMLS CUI [12])
C0065461 (UMLS CUI [13])