Age
Item
age > 18 years old and < 85 years old
boolean
C0001779 (UMLS CUI [1])
Rheumatoid Arthritis
Item
ra in accordance with american college of rheumatology 1987 criteria
boolean
C0003873 (UMLS CUI [1])
Rheumatoid arthritis moderate Disease activity score das28 C-reactive protein measurement | Rheumatoid Arthritis Severe Disease activity score das28 C-reactive protein measurement
Item
moderate or highly active ra defined as das28 > 3,2 (crp based)
boolean
C2368567 (UMLS CUI [1,1])
C4481729 (UMLS CUI [1,2])
C0201657 (UMLS CUI [1,3])
C0003873 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C4481729 (UMLS CUI [2,3])
C0201657 (UMLS CUI [2,4])
Indication TNF alpha inhibitor
Item
clinical indication for tnf-α inhibitor treatment by the treating physician
boolean
C3146298 (UMLS CUI [1,1])
C4521709 (UMLS CUI [1,2])
Medical contraindication Absent TNF alpha inhibitor
Item
no contraindications for tnf-α inhibitor treatment
boolean
C1301624 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C4521709 (UMLS CUI [1,3])
Medical contraindication Absent MRI
Item
no contraindications for mri
boolean
C1301624 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0024485 (UMLS CUI [1,3])
Serum creatinine normal
Item
serum creatinine in normal range
boolean
C0438244 (UMLS CUI [1])
Childbearing Potential Contraceptive methods Sufficient
Item
sufficient contraception for fertile women
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0205410 (UMLS CUI [1,3])
Informed Consent
Item
capable of giving informed consent
boolean
C0021430 (UMLS CUI [1])
Protocol Compliance
Item
capable of complying with the examination program of the protocol
boolean
C0525058 (UMLS CUI [1])
DMARDs | Exception Methotrexate
Item
other dmards than mtx from less than 4 weeks before inclusion and throughout the study period
boolean
C0242708 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0025677 (UMLS CUI [2,2])
Cyclophosphamide | Chlorambucil | Alkylating Agents
Item
cyclophosphamide, chlorambucil or other alkylating agents from less than 4 weeks before inclusion and throughout the study period
boolean
C0010583 (UMLS CUI [1])
C0008163 (UMLS CUI [2])
C0002073 (UMLS CUI [3])
Glucocorticoids Intramuscular injection | Glucocorticoids Intravenous Injection
Item
intramuscular or intravenous injection of glucocorticoid from less than 4 weeks before inclusion and throughout the study period
boolean
C0017710 (UMLS CUI [1,1])
C0021492 (UMLS CUI [1,2])
C0017710 (UMLS CUI [2,1])
C0021494 (UMLS CUI [2,2])
Pregnancy, Planned | Pregnancy | Breast Feeding
Item
pregnancy wish, pregnancy or breast-feeding
boolean
C0032992 (UMLS CUI [1])
C0032961 (UMLS CUI [2])
C0006147 (UMLS CUI [3])
Medical contraindication TNF alpha inhibitor
Item
contraindications for tnf-α inhibitor treatment
boolean
C1301624 (UMLS CUI [1,1])
C4521709 (UMLS CUI [1,2])
Medical contraindication MRI
Item
contraindications for mri
boolean
C1301624 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])
Substance Use Disorders
Item
known recent drug or alcohol abuse
boolean
C0038586 (UMLS CUI [1])
Informed Consent failed
Item
failure to provide written consent
boolean
C0021430 (UMLS CUI [1,1])
C0231175 (UMLS CUI [1,2])
Protocol Compliance Unable | Etiology Physically Handicapped | Etiology Mental handicap
Item
incapable of complying with the examination program for physical or mental reasons
boolean
C0525058 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0015127 (UMLS CUI [2,1])
C0086807 (UMLS CUI [2,2])
C0015127 (UMLS CUI [3,1])
C1306341 (UMLS CUI [3,2])