Rheumatoid Arthritis | Morning stiffness joint Duration | Arthritis Joints Quantity Duration | Arthritis Hand joint Duration | Arthritis Symmetric Duration | Rheumatoid Nodules | Rheumatoid factor presence in serum | Change Posteroanterior radiography Hand | Change Posteroanterior radiography Wrist | Age
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1. rheumatoid arthritis patients will meet american college of rheumatology revised criteria (arnett, edworthy et al. 1988). this requires at least four of the following seven criteria: 1) morning joint stiffness; 2) arthritis in 3 or more joint areas; 3) arthritis of hand joints; 4) symmetric arthritis; 5) rheumatoid nodules; 6) presence of serum rheumatoid factor and 7) changes on posteroanterior hand and wrist radiographs. in addition, criteria 1-4 must be present for at least four weeks. subjects must be between 18 and 85 years of age.
boolean
C0003873 (UMLS CUI [1])
C0457086 (UMLS CUI [2,1])
C0449238 (UMLS CUI [2,2])
C0003864 (UMLS CUI [3,1])
C0022417 (UMLS CUI [3,2])
C1265611 (UMLS CUI [3,3])
C0449238 (UMLS CUI [3,4])
C0003864 (UMLS CUI [4,1])
C0459470 (UMLS CUI [4,2])
C0449238 (UMLS CUI [4,3])
C0003864 (UMLS CUI [5,1])
C0332516 (UMLS CUI [5,2])
C0449238 (UMLS CUI [5,3])
C0035450 (UMLS CUI [6])
C4481755 (UMLS CUI [7])
C0392747 (UMLS CUI [8,1])
C0202573 (UMLS CUI [8,2])
C0018563 (UMLS CUI [8,3])
C0392747 (UMLS CUI [9,1])
C0202573 (UMLS CUI [9,2])
C0043262 (UMLS CUI [9,3])
C0001779 (UMLS CUI [10])
Rheumatoid Arthritis | DMARDs Dose Stable | Methotrexate | Sulfasalazine | Hydroxychloroquine
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2. if rheumatoid arthritis patients are receiving treatment with traditional disease modifying antirheumatic drugs (dmard), such as methotrexate, sulfasalazine or hydroxychloroquine, they must be on a stable regime for one month before study and stable throughout study.
boolean
C0003873 (UMLS CUI [1])
C0242708 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0205360 (UMLS CUI [2,3])
C0025677 (UMLS CUI [3])
C0036078 (UMLS CUI [4])
C0020336 (UMLS CUI [5])
Rheumatoid Arthritis | Anti-TNF drug | Anti-TNF drug Free Duration | Biological agent | Biological agent Free Duration
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3. if rheumatoid arthritis patients have received treatment with a tnf antagonist or other biologic medication, they must be drug free for greater than 3 months.
boolean
C0003873 (UMLS CUI [1])
C1562242 (UMLS CUI [2])
C1562242 (UMLS CUI [3,1])
C0332296 (UMLS CUI [3,2])
C0449238 (UMLS CUI [3,3])
C0005515 (UMLS CUI [4])
C0005515 (UMLS CUI [5,1])
C0332296 (UMLS CUI [5,2])
C0449238 (UMLS CUI [5,3])
Steroids | Prednisone Dosage Equivalent
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1. steroids - individuals currently taking greater than an equivalent of 10 mg of prednisone will be excluded given the potent anti-inflammatory effects of such medications.
boolean
C0038317 (UMLS CUI [1])
C0032952 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0205163 (UMLS CUI [2,3])
Opioids Daily Dose Multiple | Oxycodone | Percocet | Hydrocodone | Vicodin | Morphine | Dilaudid
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2. opioids - individuals using multiple daily dosage schedule of opioid agents such as oxycodone (percocet), hydrocodone (vicodin), morphine, dilaudid will be excluded.
boolean
C0242402 (UMLS CUI [1,1])
C2348070 (UMLS CUI [1,2])
C0439064 (UMLS CUI [1,3])
C0030049 (UMLS CUI [2])
C0086787 (UMLS CUI [3])
C0020264 (UMLS CUI [4])
C0483514 (UMLS CUI [5])
C0026549 (UMLS CUI [6])
C0728755 (UMLS CUI [7])
Comorbidity Unstable Uncontrolled | Diabetes Mellitus | Cardiovascular Diseases | Malignant Neoplasms | Inflammatory disorder | Crohn Disease | Ulcerative Colitis | Autoimmune Diseases | Medical condition Uncontrolled Interferes with Interventional procedure | Medical condition Uncontrolled Study Subject Participation Status At risk
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3. co-morbid medical disorders - the presence of active unstable and uncontrolled co-morbid medical conditions such as diabetes, cardiovascular diseases, and cancer will be exclusionary criteria. in particular, individuals with co-morbid inflammatory disorders such as crohn's disease and ulcerative colitis and other autoimmune disorders will be excluded. any uncontrolled medical condition that is deemed by the investigators to interfere with the proposed study procedures, or put the study participant at undue risk will also be considered exclusionary criteria.
boolean
C0009488 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
C0011849 (UMLS CUI [2])
C0007222 (UMLS CUI [3])
C0006826 (UMLS CUI [4])
C1290884 (UMLS CUI [5])
C0010346 (UMLS CUI [6])
C0009324 (UMLS CUI [7])
C0004364 (UMLS CUI [8])
C3843040 (UMLS CUI [9,1])
C0205318 (UMLS CUI [9,2])
C0521102 (UMLS CUI [9,3])
C0184661 (UMLS CUI [9,4])
C3843040 (UMLS CUI [10,1])
C0205318 (UMLS CUI [10,2])
C2348568 (UMLS CUI [10,3])
C1444641 (UMLS CUI [10,4])
Chronic infectious disease
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4. chronic infections - individuals with chronic infections will also be excluded because of effects on immune markers measured in study.
boolean
C0151317 (UMLS CUI [1])
Pain Disorder | Fibromyalgia Interferes with Findings | Sleep abnormalities | Fatigue Daytime | Pain Daytime
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5. co-morbid pain disorders - individuals with co-morbid pain disorders such as fibromyalgia will also be excluded. individuals with fibromyalgia have been found to have sleep abnormalities as well as daytime fatigue and pain (drewes 1999) and thus could confound findings.
boolean
C0391976 (UMLS CUI [1])
C0016053 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C2607943 (UMLS CUI [2,3])
C3277092 (UMLS CUI [3])
C0015672 (UMLS CUI [4,1])
C0332169 (UMLS CUI [4,2])
C0030193 (UMLS CUI [5,1])
C0332169 (UMLS CUI [5,2])
Major Depressive Disorder | Bipolar Disorder | At risk for suicide
Item
6. psychiatric disorders - current conditions such as major depressive disorder, bipolar disorder and risk for suicide will also be considered exclusionary criteria.
boolean
C1269683 (UMLS CUI [1])
C0005586 (UMLS CUI [2])
C0563664 (UMLS CUI [3])
Pregnancy | Breast Feeding
Item
7. gender-based criteria - pregnant or breast-feeding women will also be excluded because of their effects on neuroendocrine systems and sleep
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])