Age
Item
participants must be over the age of 18 years
boolean
C0001779 (UMLS CUI [1])
Male
Item
male
boolean
C1706180 (UMLS CUI [1])
Women without child-bearing potential
Item
women who do not have child-bearing potential (history of hysterectomy, post-menopausal)
boolean
C3831118 (UMLS CUI [1,1])
C0332268 (UMLS CUI [1,2])
Biopsy confirmed bcc
Item
have a biopsy confirmed bcc that measures at least 6mm in size at the time of the initial evaluation (visit #1);
boolean
C0007117 (UMLS CUI [1,1])
C0005558 (UMLS CUI [1,2])
C0449453 (UMLS CUI [2])
Protocol Compliance
Item
participant must be willing and comply with the requirements of the protocol;
boolean
C0525058 (UMLS CUI [1])
Able to understand and communicate
Item
participant must have the ability to understand and communicate with the investigator;
boolean
C2364293 (UMLS CUI [1])
C0162340 (UMLS CUI [2])
Informed consent
Item
participant must provide informed consent.
boolean
C0021430 (UMLS CUI [1])
History of Congestive heart failure, chronic renal failure, hepatic failure, neuropathy
Item
subject with significant congestive heart failure (chf) or history of chf, chronic renal failure, hepatic failure, neuropathy
boolean
C0018802 (UMLS CUI [1,1])
C0521116 (UMLS CUI [1,2])
C0018802 (UMLS CUI [2,1])
C0262926 (UMLS CUI [2,2])
C0022661 (UMLS CUI [3])
C0085605 (UMLS CUI [4])
C0442874 (UMLS CUI [5])
Skin diseases
Item
subject with current skin diseases that the investigator feels is not safe for study participation including but not limited to severe atopic dermatitis, cutaneous t-cell lymphoma, erythroderma;
boolean
C0037274 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0036043 (UMLS CUI [1,3])
C0011615 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0079773 (UMLS CUI [3])
C0598398 (UMLS CUI [4])
Systemic medication affecting hedgehog pathway
Item
subjects on systemic medications known to affect the hedgehog pathway (see appendix i)
boolean
C1515119 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C1155468 (UMLS CUI [1,3])
Cisapride, oral midazolam, nisoldipine, felodipine, pimozide, quinidine, dofetilide, triazolam, methadone, levacetylmethadol, lovastatin, simvastatin, dihydroergotamine, ergometrine, ergotamine and methylergometrine
Item
subjects on cisapride, oral midazolam, nisoldipine, felodipine, pimozide, quinidine, dofetilide, triazolam, methadone, levacetylmethadol (levomethadyl), lovastatin, simvastatin, dihydroergotamine, ergometrine (ergonovine), ergotamine and methylergometrine (methylergonovine), cisapride, pimozide, methadone, levacetylmethadol (levomethadyl), quinidine
boolean
C0072916 (UMLS CUI [1])
C0026056 (UMLS CUI [2,1])
C0442027 (UMLS CUI [2,2])
C0028116 (UMLS CUI [3])
C0015772 (UMLS CUI [4])
C0031935 (UMLS CUI [5])
C0034414 (UMLS CUI [6])
C0114771 (UMLS CUI [7])
C0040879 (UMLS CUI [8])
C0025605 (UMLS CUI [9])
C0772342 (UMLS CUI [10])
C0024027 (UMLS CUI [11])
C0074554 (UMLS CUI [12])
C0012291 (UMLS CUI [13])
C0014710 (UMLS CUI [14])
C0025760 (UMLS CUI [15])
Hypersensitivity to azoles
Item
subjects with history of hypersensitivity to azoles
boolean
C0020517 (UMLS CUI [1,1])
C0004504 (UMLS CUI [1,2])
Gorlin Syndrome
Item
subjects with gorlin syndrome
boolean
C0004779 (UMLS CUI [1])
Chronic immunosuppression or history of compromised immune function
Item
subjects on chronic immunosuppression, or who have a history of compromised immune function (e.g. history of or current malignancy other than bcc/squamous cell skin cancers)
boolean
C0021079 (UMLS CUI [1])
C4048329 (UMLS CUI [2,1])
C0262926 (UMLS CUI [2,2])
C0006826 (UMLS CUI [3,1])
C0205394 (UMLS CUI [3,2])
Not able to speak english or hearing disorder, not able to provide informed consent
Item
subjects who do not speak english or have difficulty hearing or are otherwise impaired for providing informed consent and communicating with the investigator;
boolean
C0376245 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C1384666 (UMLS CUI [2])
C0021430 (UMLS CUI [3,1])
C1299582 (UMLS CUI [3,2])
C0332268 (UMLS CUI [4,1])
C2364293 (UMLS CUI [4,2])
C0035173 (UMLS CUI [4,3])
History of keloids or excessive scarring
Item
subjects with a history of keloids or excessive scarring;
boolean
C0022548 (UMLS CUI [1,1])
C0262926 (UMLS CUI [1,2])
C0262926 (UMLS CUI [2,1])
C0008767 (UMLS CUI [2,2])
C0442802 (UMLS CUI [2,3])
Allergy to lidocaine, epinephrine, itraconazole or petrolatum
Item
subjects with known allergy to lidocaine, epinephrine, itraconazole or petrolatum
boolean
C0020517 (UMLS CUI [1,1])
C0014563 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0023660 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C0064113 (UMLS CUI [3,2])
C0020517 (UMLS CUI [4,1])
C0031262 (UMLS CUI [4,2])
Women of child-bearing age and able to conceive
Item
women of child-bearing age/potential and/or able to conceive
boolean
C3831118 (UMLS CUI [1])