ACR Criteria Fulfill Rheumatoid Arthritis
Item
must have met acr criteria for the diagnosis of rheumatoid arthritis (ra)
boolean
C3273747 (UMLS CUI [1,1])
C1550543 (UMLS CUI [1,2])
C0003873 (UMLS CUI [1,3])
Rheumatoid Arthritis
Item
must have active ra
boolean
C0003873 (UMLS CUI [1])
Methotrexate U/week Stable
Item
must be treated with methotrexate (mtx) (10 to 25 mg weekly) for at least 3 months and have received a stable dose for at least 28 days prior to the anticipated study drug administration date.
boolean
C0025677 (UMLS CUI [1,1])
C0560588 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
DMARDs To be stopped | Biological agents To be stopped | Leflunomide To be stopped | Infliximab To be stopped | Adalimumab To be stopped | Abatacept To be stopped
Item
all other dmards or biologics must be discontinued at least 28 days prior to study drug administration and: 1) leflunomide, which must be discontinued at least 60 days before study drug administration, 2) infliximab, adalimumab, and abatacept must be discontinued at least 56 days prior to study drug administration
boolean
C0242708 (UMLS CUI [1,1])
C1272691 (UMLS CUI [1,2])
C0005515 (UMLS CUI [2,1])
C1272691 (UMLS CUI [2,2])
C0063041 (UMLS CUI [3,1])
C1272691 (UMLS CUI [3,2])
C0666743 (UMLS CUI [4,1])
C1272691 (UMLS CUI [4,2])
C1122087 (UMLS CUI [5,1])
C1272691 (UMLS CUI [5,2])
C1619966 (UMLS CUI [6,1])
C1272691 (UMLS CUI [6,2])
Rheumatoid factor negative | Anti-CCP Negative
Item
both rheumatoid factor and anti-ccp negative
boolean
C0427391 (UMLS CUI [1])
C4318437 (UMLS CUI [2,1])
C1513916 (UMLS CUI [2,2])
B-cell depletion therapy
Item
prior treatment with any b-cell depleting therapy
boolean
C1171324 (UMLS CUI [1])
Fusion protein Immunoglobulin Based
Item
any other mab or ig-based fusion proteins 56 days or less prior to visit
boolean
C0162768 (UMLS CUI [1,1])
C0021027 (UMLS CUI [1,2])
C1705938 (UMLS CUI [1,3])
Inflammatory joint disease | Exception Rheumatoid Arthritis
Item
history of or current inflammatory joint disease other than ra
boolean
C0683381 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0003873 (UMLS CUI [2,2])
Neuropathy Interferes with Evaluation Pain | Neurovascular Disorder Interferes with Evaluation Pain
Item
neuropathies or neurovasculopathies that might interfere with pain evaluation
boolean
C0442874 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C1261322 (UMLS CUI [1,3])
C0030193 (UMLS CUI [1,4])
C3898144 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C1261322 (UMLS CUI [2,3])
C0030193 (UMLS CUI [2,4])
Complications Rheumatoid Arthritis | Disease complications
Item
complications of ra or other disease
boolean
C0009566 (UMLS CUI [1,1])
C0003873 (UMLS CUI [1,2])
C0544688 (UMLS CUI [2])
Autoimmune Disease | Exception Rheumatoid Arthritis
Item
any other autoimmune disease other than ra
boolean
C0004364 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0003873 (UMLS CUI [2,2])
Communicable Disease | Chronic infectious disease
Item
acute or chronic infection
boolean
C0009450 (UMLS CUI [1])
C0151317 (UMLS CUI [2])
Disease Clinical Significance
Item
clinically significant disease requiring
boolean
C0012634 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])