Age
Item
subjects between 60 and 90 years old
boolean
C0001779 (UMLS CUI [1])
NINCDS-ADRDA for AD2, DSM-IV criteria for dementia, MMSE
Item
subjects meeting nincds-adrda criteria for probable ad2 and dsm-iv criteria for dementia of the alzheimer's type3 will be recruited in the ad cohort (mmse ≥21, ≤26).
boolean
C2828081 (UMLS CUI [1,1])
C0002395 (UMLS CUI [1,2])
C0220952 (UMLS CUI [2,1])
C0497327 (UMLS CUI [2,2])
C0002395 (UMLS CUI [2,3])
C0451306 (UMLS CUI [3])
Memory complaint
Item
memory complaint by subject and/or study partner srp-1418 n page: 8 of 26
boolean
C0439655 (UMLS CUI [1,1])
C0233794 (UMLS CUI [1,2])
C0277786 (UMLS CUI [1,3])
C0233794 (UMLS CUI [2,1])
C0277786 (UMLS CUI [2,2])
C2079578 (UMLS CUI [2,3])
Memory function by wechsler memory scale, education
Item
abnormal memory function score on logical memory ii subscale (delayed paragraph recall) from the wechsler memory scale - revised (adjusted for education. maximum score is 25): i. < 10 for 16 or more years of education ii. < 6 for 8-15 years of education iii. < 4 for 0-7 years of education
boolean
C4027320 (UMLS CUI [1,1])
C0456081 (UMLS CUI [1,2])
C0013658 (UMLS CUI [1,3])
C4027320 (UMLS CUI [2,1])
C0589057 (UMLS CUI [2,2])
CDR, HIS, GDS
Item
clinical dementia rating (cdr) = 0.5, 1.0 or 2.0 modified hachinski ischemic scale (his) ≤ 4 geriatric depression scale (gds) < 6
boolean
C0451074 (UMLS CUI [1])
C3826978 (UMLS CUI [2])
C1954099 (UMLS CUI [3])
CSF, Platelet count, PT, INR
Item
for subjects that decide to provide a csf sample: platelet count ≥ 100,000/μl, prothrombin time (pt) = 11 to 16 seconds, international normalized ratio = 0.8 to 1.2
boolean
C0007806 (UMLS CUI [1,1])
C0680240 (UMLS CUI [1,2])
C0005821 (UMLS CUI [2])
C0033707 (UMLS CUI [3])
C0525032 (UMLS CUI [4])
study partner/caregiver to accompany subject to all scheduled visits
Item
study partner or caregiver to accompany subject to all scheduled visits
boolean
C2079578 (UMLS CUI [1])
C0085537 (UMLS CUI [2])
Fluently speaking english
Item
fluent in english
boolean
C0564241 (UMLS CUI [1,1])
C0376245 (UMLS CUI [1,2])
Visual acuity to allow neuropsychological testing
Item
adequate visual acuity to allow neuropsychological testing
boolean
C0042812 (UMLS CUI [1,1])
C0205410 (UMLS CUI [1,2])
C0027902 (UMLS CUI [1,3])
Auditory acuity to allow neuropsychological testing, erp testing
Item
adequate auditory acuity to allow neuropsychological and erp testing
boolean
C0679027 (UMLS CUI [1,1])
C0205410 (UMLS CUI [1,2])
C0027902 (UMLS CUI [1,3])
C0282171 (UMLS CUI [1,4])
C0039593 (UMLS CUI [1,5])
Healthy, no other diseases/conditions
Item
good general health with no additional diseases expected to interfere with the study
boolean
C1277245 (UMLS CUI [1])
C2359476 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C2603343 (UMLS CUI [2,3])
Willingness to neuroimaging and blood; CSF and diagnostic lumbar puncture
Item
willing to undergo neuroimaging and provide blood. the subject may optionally provide a csf sample by lumbar puncture.
boolean
C0600109 (UMLS CUI [1,1])
C0679575 (UMLS CUI [1,2])
C0600109 (UMLS CUI [2,1])
C0005834 (UMLS CUI [2,2])
C0007806 (UMLS CUI [3,1])
C0553794 (UMLS CUI [3,2])
Matched for age, gender and education level (mmse ≥ 27)
Item
healthy subjects matched for age, gender, and education level will be recruited as normal controls (mmse ≥ 27).
boolean
C1708335 (UMLS CUI [1])
C0001779 (UMLS CUI [2,1])
C1708943 (UMLS CUI [2,2])
C0079399 (UMLS CUI [3,1])
C1708943 (UMLS CUI [3,2])
C0013658 (UMLS CUI [4,1])
C1708943 (UMLS CUI [4,2])
C0451306 (UMLS CUI [5])
Memory function, wechsler memory scale, education
Item
normal memory function will be documented by scoring at specific cutoffs on the logical memory ii subscale (delayed paragraph recall) from the wechsler memory scale - revised: i. ≥ 10 for 16 or more years of education ii. ≥ 6 for 8-15 years of education iii. ≥ 4 for 0-7 years of education
boolean
C4027320 (UMLS CUI [1,1])
C0456081 (UMLS CUI [1,2])
C0013658 (UMLS CUI [1,3])
C4027320 (UMLS CUI [2,1])
C0589057 (UMLS CUI [2,2])
study partner/ caregiver
Item
study partner or caregiver
boolean
C2079578 (UMLS CUI [1])
C0085537 (UMLS CUI [2])
Fluently speaking english
Item
fluent in english
boolean
C0564241 (UMLS CUI [1,1])
C0376245 (UMLS CUI [1,2])
Visual acuity to allow neuropsychological testing
Item
adequate visual acuity to allow neuropsychological testing
boolean
C0042812 (UMLS CUI [1,1])
C0205410 (UMLS CUI [1,2])
C0027902 (UMLS CUI [1,3])
Auditory acuity to allow neuropsychological, erp testing
Item
adequate auditory acuity to allow neuropsychological and erp testing
boolean
C0679027 (UMLS CUI [1,1])
C0205410 (UMLS CUI [1,2])
C0027902 (UMLS CUI [1,3])
C0282171 (UMLS CUI [1,4])
Diabetes, heart disease, HIV, drug/alcohol abuse, severe AD, MMSE
Item
severe or unstable forms of diabetes, heart disease, hiv, drug or alcohol abuse, etc. including severe ad:mmse ≤20
boolean
C0011849 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0011849 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0018799 (UMLS CUI [3])
C0019682 (UMLS CUI [4])
C0013146 (UMLS CUI [5,1])
C0085762 (UMLS CUI [5,2])
C0205082 (UMLS CUI [6,1])
C0002395 (UMLS CUI [6,2])
C0451306 (UMLS CUI [6,3])
Platelet count, PT, INR
Item
platelet count < 100,000/μl, prothrombin time (pt) > 16 seconds, international normalized ratio > 1.2 (for subjects that choose to provide a csf sample by lumbar puncture).
boolean
C0553794 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
C0680240 (UMLS CUI [1,3])
C0032181 (UMLS CUI [2])
C0033707 (UMLS CUI [3])
C0525032 (UMLS CUI [4])
Medical or psychiatric disorders complicating assessment of dementia
Item
medical or psychiatric disorders that might complicate the assessment of dementia (i.e., mental retardation, alcohol abuse, drug abuse, hiv)
boolean
C0205476 (UMLS CUI [1,1])
C0012634 (UMLS CUI [1,2])
C0009566 (UMLS CUI [1,3])
C1516048 (UMLS CUI [1,4])
C0497327 (UMLS CUI [1,5])
C0004936 (UMLS CUI [2,1])
C0009566 (UMLS CUI [2,2])
C1516048 (UMLS CUI [2,3])
C0497327 (UMLS CUI [2,4])
C0025362 (UMLS CUI [3])
C0085762 (UMLS CUI [4])
C0013146 (UMLS CUI [5])
C0019682 (UMLS CUI [6])
Disability of completing study requirements
Item
a disability that may prevent the subject from completing all study requirements (e.g., blindness, deafness, language difficulty)
boolean
C0231170 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
C0456909 (UMLS CUI [2])
C0011053 (UMLS CUI [3])
C0566027 (UMLS CUI [4])
Recent intake of drugs causing major organ system toxicity or cns alteration
Item
recent intake of drugs known to cause major organ system toxicity or cns alteration (e.g. sedation)
boolean
C0332185 (UMLS CUI [1,1])
C0013227 (UMLS CUI [1,2])
C0013221 (UMLS CUI [1,3])
C0678852 (UMLS CUI [1,4])
C0332185 (UMLS CUI [2,1])
C0013227 (UMLS CUI [2,2])
C3160947 (UMLS CUI [2,3])
C0344106 (UMLS CUI [3])
Diseases of the dementia type except than AD
Item
diseases of the dementia type other than ad (i.e., vascular dementia, frontotemporal dementia, lewy body disease, huntington's disease)
boolean
C0497327 (UMLS CUI [1,1])
C0332300 (UMLS CUI [1,2])
C0002395 (UMLS CUI [1,3])
C0011269 (UMLS CUI [2])
C0338451 (UMLS CUI [3])
C0752347 (UMLS CUI [4])
C0020179 (UMLS CUI [5])
Non-mri compatible implants/ devices
Item
presence of non-mri compatible implants/devices
boolean
C0021102 (UMLS CUI [1,1])
C0522473 (UMLS CUI [1,2])
C0024485 (UMLS CUI [1,3])
Prohibited medication (Warfarin, anticoagulants), csf sample by lumbar puncture, investigational agents
Item
prohibited medications: warfarin or other anticoagulants (for subjects that choose to provide a csf sample by lumbar puncture), investigational agents.
boolean
C0043031 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
C0553794 (UMLS CUI [1,3])
C0003280 (UMLS CUI [2,1])
C0007806 (UMLS CUI [2,2])
C0553794 (UMLS CUI [2,3])
C0013227 (UMLS CUI [3,1])
C0683610 (UMLS CUI [3,2])
C0013230 (UMLS CUI [4])
Diabetes Mellitus, heart diseases, HIV, drug or alcohol abuse
Item
severe or unstable forms of diabetes, heart disease, hiv, drug or alcohol abuse, etc.
boolean
C0011849 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0011849 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0018799 (UMLS CUI [3])
C0019682 (UMLS CUI [4])
C0013146 (UMLS CUI [5,1])
C0085762 (UMLS CUI [5,2])
Disability of completing study requirements
Item
a disability that may prevent the subject from completing all study requirements (e.g., blindness, deafness, language difficulty)
boolean
C0231170 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
C0456909 (UMLS CUI [2])
C0011053 (UMLS CUI [3])
C0566027 (UMLS CUI [4])
Psychoactive drugs, SSRI's accepted
Item
use of psychoactive drugs (only ssri's are allowed)
boolean
C0033978 (UMLS CUI [1])
C0033978 (UMLS CUI [2,1])
C1705847 (UMLS CUI [2,2])
C0360105 (UMLS CUI [2,3])
Psychiatric disorders
Item
psychiatric disorders (schizophrenia, bipolar, etc.)
boolean
C0004936 (UMLS CUI [1])
C0036341 (UMLS CUI [2])
C0005586 (UMLS CUI [3])
GDS
Item
depression (gds > 6)
boolean
C0011581 (UMLS CUI [1])
C1954099 (UMLS CUI [2])
Other forms of dementia, HIS, CDR
Item
vascular dementia (his > 4) other dementia (cdr > 0)
boolean
C0011269 (UMLS CUI [1,1])
C0475492 (UMLS CUI [1,2])
C0205394 (UMLS CUI [2,1])
C0497327 (UMLS CUI [2,2])
C0451074 (UMLS CUI [2,3])
Memory function, wechsler memory scale, education
Item
abnormal memory function score on wechsler memory scale -logical memory ii subscale (delayed paragraph recall) from the wechsler memory scale - revised (the maximum score is 25): i. < 10 for 16 or more years of education ii. < 6 for 8-15 years of education iii. < 4 for 0-7 years of education
boolean
C4027320 (UMLS CUI [1,1])
C0456081 (UMLS CUI [1,2])
C0013658 (UMLS CUI [1,3])
C4027320 (UMLS CUI [2,1])
C0589057 (UMLS CUI [2,2])