Non-Small Cell Lung Carcinoma TNM clinical staging | Pleural effusion
Item
pathologically determined stage iv nsclc including stage iiib (pleural effusion)
boolean
C0007131 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
C0032227 (UMLS CUI [2])
Chemotherapy Platinum-Based Quantity failed | Non-Small Cell Lung Carcinoma TNM clinical staging | Adjuvant Chemotherapy Platinum-Based Ineligible
Item
failed at least one prior platinum-based chemotherapy for stage iiib or stage iv nsclc. patients receiving platinum-based chemotherapy only given in an adjuvant setting are not eligible.
boolean
C0392920 (UMLS CUI [1,1])
C1514162 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0231175 (UMLS CUI [1,4])
C0007131 (UMLS CUI [2,1])
C3258246 (UMLS CUI [2,2])
C0085533 (UMLS CUI [3,1])
C1514162 (UMLS CUI [3,2])
C1512714 (UMLS CUI [3,3])
Measurable Disease
Item
measurable disease by recist
boolean
C1513041 (UMLS CUI [1])
Age
Item
greater than or equal to 18 years of age
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
ecog ps of 0 or 1
boolean
C1520224 (UMLS CUI [1])
Therapeutic radiology procedure | Chemotherapy | Investigational New Drugs | Exception Cytotoxic agent
Item
radiation therapy within 2 weeks; chemotherapy within 3 weeks; non-cytotoxic investigational agents within 4 weeks of initiating study treatment
boolean
C1522449 (UMLS CUI [1])
C0392920 (UMLS CUI [2])
C0013230 (UMLS CUI [3])
C1705847 (UMLS CUI [4,1])
C0304497 (UMLS CUI [4,2])
Heart Disease New York Heart Association Classification
Item
evidence of nyha class iii or greater cardiac disease
boolean
C0018799 (UMLS CUI [1,1])
C1275491 (UMLS CUI [1,2])
Myocardial Infarction | Cerebrovascular accident | Ventricular arrhythmia | Cardiac conduction abnormality Symptomatic
Item
history of mi, stroke, ventricular arrhythmia, or symptomatic conduction abnormality within 12 months
boolean
C0027051 (UMLS CUI [1])
C0038454 (UMLS CUI [2])
C0085612 (UMLS CUI [3])
C1842820 (UMLS CUI [4,1])
C0231220 (UMLS CUI [4,2])
HIV Infection | AIDS
Item
known hiv infection or aids
boolean
C0019693 (UMLS CUI [1])
C0001175 (UMLS CUI [2])
CNS metastases Symptomatic
Item
symptomatic cns metastases
boolean
C0686377 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
Pregnancy | Breast Feeding
Item
pregnant or nursing women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Hypersensitivity Erlotinib | Intolerance to Erlotinib | Allergy to sulfonamides | Intolerance to Sulfonamides | Aspirin allergy | Intolerance to Aspirin | Allergy to nonsteroidal anti-inflammatory agents | Intolerance to NSAIDs
Item
hypersensitivity or intolerance to erlotinib, sulfonamides, aspirin, or other nsaids.
boolean
C0020517 (UMLS CUI [1,1])
C1135135 (UMLS CUI [1,2])
C1744706 (UMLS CUI [2,1])
C1135135 (UMLS CUI [2,2])
C0038757 (UMLS CUI [3])
C1744706 (UMLS CUI [4,1])
C0038760 (UMLS CUI [4,2])
C0004058 (UMLS CUI [5])
C1744706 (UMLS CUI [6,1])
C0004057 (UMLS CUI [6,2])
C0746949 (UMLS CUI [7])
C1744706 (UMLS CUI [8,1])
C0003211 (UMLS CUI [8,2])
Upper gastrointestinal hemorrhage | Upper Gastrointestinal Tract Ulceration | Upper gastrointestinal perforation
Item
history of upper gi bleeding, ulceration, or perforation
boolean
C0041909 (UMLS CUI [1])
C3203348 (UMLS CUI [2,1])
C3887532 (UMLS CUI [2,2])
C0749862 (UMLS CUI [3])
Cyclooxygenase 2 Inhibitors | Therapeutic procedure Non-small cell lung cancer metastatic
Item
prior history of cox-2 inhibitor therapy for the treatment of metastatic nsclc
boolean
C1257954 (UMLS CUI [1])
C0087111 (UMLS CUI [2,1])
C0278987 (UMLS CUI [2,2])
EGFR Tyrosine Kinase Inhibitor Therapy
Item
previous anti-egfr kinase therapy
boolean
C3899317 (UMLS CUI [1])