Adenocarcinoma of prostate
Item
histological confirmation of prostate adenocarcinoma
boolean
C0007112 (UMLS CUI [1])
Secondary malignant neoplasm of bone Bone scan | Secondary malignant neoplasm of bone MRI
Item
documented evidence of bone metastasis on bone scan or mri
boolean
C0153690 (UMLS CUI [1,1])
C0203668 (UMLS CUI [1,2])
C0153690 (UMLS CUI [2,1])
C0024485 (UMLS CUI [2,2])
Prostate carcinoma Progression Biochemical
Item
biochemical progression of prostate cancer
boolean
C0600139 (UMLS CUI [1,1])
C0242656 (UMLS CUI [1,2])
C0205474 (UMLS CUI [1,3])
Male Castration | Medical Castration | Serum testosterone measurement
Item
surgically or medically castrate with serum testosterone ≤2.4nmol/l
boolean
C0007347 (UMLS CUI [1])
C1513054 (UMLS CUI [2])
C0428413 (UMLS CUI [3])
ECOG performance status
Item
ecog performance status 0 - 2
boolean
C1520224 (UMLS CUI [1])
Life Expectancy
Item
life expectancy of 6 months or more.
boolean
C0023671 (UMLS CUI [1])
Therapeutic radiology procedure Bone lesion | Therapeutic radiology procedure Prostate Bed
Item
radiotherapy to bone lesion or prostatic bed within 4 weeks of starting study treatment.
boolean
C1522449 (UMLS CUI [1,1])
C0238792 (UMLS CUI [1,2])
C1522449 (UMLS CUI [2,1])
C2983573 (UMLS CUI [2,2])
Targeted cancer therapy | gefitinib | bevacizumab
Item
prior targeted cancer therapies (such as gefitinib, bevacizumab)
boolean
C3854476 (UMLS CUI [1])
C1122962 (UMLS CUI [2])
C0796392 (UMLS CUI [3])
Radionuclide therapy Systemic
Item
systemic radionuclide therapy within 12 weeks of starting study treatment.
boolean
C0203608 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
CYP3A4 Inhibitors | Ketoconazole | Itraconazole | Ritonavir | Indinavir | Erythromycin | Troleandomycin | Clarithromycin | Diltiazem | Verapamil | CYP2D6 Inhibitors | CYP2C9 Inhibitors | Quinidine | Fluconazole | Cytochrome P450 Inducer | Phenytoin | Rifampin | Carbamazepine | Phenobarbital
Item
current therapy, within 4 weeks of study entry with potent inhibitors of cyp3a4 (ketoconazole, itraconazole, ritonavir, indinavir, erythromycin, troleandomycin, clarithromycin, diltiazem and verapamil), inhibitors of cyps 2d6 and 2c9 (quinidine and fluconazole), and potent p450 inducers (phenytoin, rifampicin, carbamazepine and phenobarbitone)
boolean
C3850053 (UMLS CUI [1])
C0022625 (UMLS CUI [2])
C0064113 (UMLS CUI [3])
C0292818 (UMLS CUI [4])
C0376637 (UMLS CUI [5])
C0014806 (UMLS CUI [6])
C0041165 (UMLS CUI [7])
C0055856 (UMLS CUI [8])
C0012373 (UMLS CUI [9])
C0042523 (UMLS CUI [10])
C3850058 (UMLS CUI [11])
C3850060 (UMLS CUI [12])
C0034414 (UMLS CUI [13])
C0016277 (UMLS CUI [14])
C0010762 (UMLS CUI [15,1])
C3898767 (UMLS CUI [15,2])
C0031507 (UMLS CUI [16])
C0035608 (UMLS CUI [17])
C0006949 (UMLS CUI [18])
C0031412 (UMLS CUI [19])
Medical History Adverse reaction to drug | Family history Adverse reaction to drug | Medical History Adverse reaction to drug Suspected | Family history Adverse reaction to drug Suspected | Hypersensitivity Endothelin antagonist
Item
definite or suspected personal history or family history of adverse drug reactions, or hypersensitivity to drugs that are endothelin antagonists
boolean
C0262926 (UMLS CUI [1,1])
C0041755 (UMLS CUI [1,2])
C0241889 (UMLS CUI [2,1])
C0041755 (UMLS CUI [2,2])
C0262926 (UMLS CUI [3,1])
C0041755 (UMLS CUI [3,2])
C0750491 (UMLS CUI [3,3])
C0241889 (UMLS CUI [4,1])
C0041755 (UMLS CUI [4,2])
C0750491 (UMLS CUI [4,3])
C0020517 (UMLS CUI [5,1])
C1134681 (UMLS CUI [5,2])
Ineligibility MRI scan | Metallic implant | Cochlear Implants | Artificial cardiac pacemaker | Heart Valve | Aneurysm clip | Metal foreign body in eye region | Hypersensitivity Gadolinium-based Contrast Agent MRI
Item
ineligibility for mri scanning includes standard mri criteria (for example, metal implants such as cochlear implants, cardiac pacemakers, heart valves, aneurysm clips and metal fragments in eyes) and patients known to be allergic to gadolinium-based mri contrast agents
boolean
C1512714 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])
C3693688 (UMLS CUI [2])
C0009199 (UMLS CUI [3])
C0030163 (UMLS CUI [4])
C0018825 (UMLS CUI [5])
C0179977 (UMLS CUI [6])
C0562528 (UMLS CUI [7])
C0020517 (UMLS CUI [8,1])
C3249258 (UMLS CUI [8,2])
C0024485 (UMLS CUI [8,3])