Age
Item
age: 18-65 years;
boolean
C0001779 (UMLS CUI [1])
Bmi
Item
bmi ≥25 kg/m2;
boolean
C1305855 (UMLS CUI [1])
plasma 25-oh-vitamin d
Item
plasma 25-oh-vitamin d between 7 and 20 ng/ml
boolean
C1255280 (UMLS CUI [1])
Stability of weight
Item
weight stable to within 10 pounds for 6 months prior to entering the study, and within 30 pounds of their lifetime maximum weight (excluding pregnancy);
boolean
C0005910 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
Ability to be admitted to the fhcrc prevention center
Item
ability to be admitted for ~6.5 hours on three occasions to the fhcrc prevention center,
boolean
C0085732 (UMLS CUI [1,1])
C2827364 (UMLS CUI [1,2])
C2825164 (UMLS CUI [1,3])
Informed consent
Item
ability to provide informed written consent;
boolean
C0021430 (UMLS CUI [1])
Compliance to protocol
Item
willingness to take vitamin d3 capsules daily for 6 months
boolean
C0525058 (UMLS CUI [1])
Chronic comorbidity such as thyroid, liver or kidney disease
Item
chronic disease such as thyroid disease, liver disease, or kidney disease;
boolean
C0040128 (UMLS CUI [1,1])
C0008679 (UMLS CUI [1,2])
C0341439 (UMLS CUI [2])
C1561643 (UMLS CUI [3])
C0008679 (UMLS CUI [4])
Diabetes mellitus or fasting glucose > 125 mg/dl
Item
diabetes mellitus, or fasting glucose >125 mg/dl;
boolean
C0011849 (UMLS CUI [1])
C0428568 (UMLS CUI [2])
Chronic inflammatory condition such as autoimmune disease or inflammatory bowel disease
Item
chronic inflammatory condition such as autoimmune disease or inflammatory bowel disease;
boolean
C1290886 (UMLS CUI [1])
C0004364 (UMLS CUI [2])
C1856359 (UMLS CUI [3])
malabsorption syndromes such as untreated celiac cisease; condition after stomach or intestinal resection
Item
malabsorption syndromes (untreated celiac disease; condition after stomach or intestinal resection);
boolean
C0024523 (UMLS CUI [1])
C0007570 (UMLS CUI [2,1])
C0332155 (UMLS CUI [2,2])
C0017118 (UMLS CUI [3])
C1096244 (UMLS CUI [4])
Current or recent drug treatment with likely interference with the study
Item
current or recent (within one month) chronic intake of medications likely to interfere with study endpoints [(insulin, antidiabetics, anabolic steroids, glucocorticosteroids, statins, blood thinners (warfarin, aspirin), non-steroidal anti-inflammatory drugs (if daily)];
boolean
C0013216 (UMLS CUI [1,1])
C0521116 (UMLS CUI [1,2])
C4054723 (UMLS CUI [1,3])
C0332185 (UMLS CUI [2,1])
C0013216 (UMLS CUI [2,2])
C4054723 (UMLS CUI [2,3])
C1264692 (UMLS CUI [2,4])
Current or recent intake of vitamin d
Item
current or recent (within 3 months) intake of vitamin d in excess of 600 iu/day;
boolean
C2317047 (UMLS CUI [1,1])
C0521116 (UMLS CUI [1,2])
C2317047 (UMLS CUI [2,1])
C0332185 (UMLS CUI [2,2])
Current or recent anemia, recent blood donation, recent or planned participation in another study involving blood draws
Item
anemia, recent history (within 3 months) of anemia; recent (within 3 months) blood donation; recent (within 3 months) participation in another study that involved blood draws; or plans to participate in other research that involves blood draws during the study period;
boolean
C0332185 (UMLS CUI [1,1])
C0002871 (UMLS CUI [1,2])
C0521116 (UMLS CUI [2,1])
C0002871 (UMLS CUI [2,2])
C0005794 (UMLS CUI [3,1])
C0332185 (UMLS CUI [3,2])
C2348568 (UMLS CUI [4,1])
C0178913 (UMLS CUI [4,2])
Current, recent or planned pregnancy or breastfeeding
Item
pregnancy in the last 6 months, plans to become pregnant during the study period, or current breastfeeding.
boolean
C0032961 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
C0032992 (UMLS CUI [2])
C0032961 (UMLS CUI [3])
C0006147 (UMLS CUI [4])