Adenocarcinoma of the prostate metastatic | BONE INVOLVEMENT | Lymph Node Involvement | Involvement with Site Other | Serum testosterone measurement Consistent with Male Castration | Progression Biochemical Prostate carcinoma | Raised prostate specific antigen
Item
males presented with a confirmed histological diagnosis of adenocarcinoma of the prostate with evidence of metastases (including bone, lymph nodes, or other site) radiologically or histologically documented and despite a serum testosterone ≤1.73 nmol/l (50 ng/dl) proving castration, evidence of biochemical progression of prostate cancer, documented by a rise in psa .
boolean
C0862636 (UMLS CUI [1])
C0741591 (UMLS CUI [2])
C0806692 (UMLS CUI [3])
C1314939 (UMLS CUI [4,1])
C1515974 (UMLS CUI [4,2])
C0205394 (UMLS CUI [4,3])
C0428413 (UMLS CUI [5,1])
C0332290 (UMLS CUI [5,2])
C0007347 (UMLS CUI [5,3])
C0449258 (UMLS CUI [6,1])
C0205474 (UMLS CUI [6,2])
C0600139 (UMLS CUI [6,3])
C0178415 (UMLS CUI [7])
Therapeutic radiology procedure | Operative Surgical Procedures | Androgen Antagonists | Exception LH-RH Analogs | Bilateral orchiectomy | Surgical incision Healed Incomplete
Item
radiotherapy or surgery or antiandrogens (except lhrh analogue) or bilateral orchiectomy within the 30 days preceding visit 1. incompletely healed surgical incision.
boolean
C1522449 (UMLS CUI [1])
C0543467 (UMLS CUI [2])
C0002842 (UMLS CUI [3])
C1705847 (UMLS CUI [4,1])
C1518041 (UMLS CUI [4,2])
C0007347 (UMLS CUI [5])
C0184898 (UMLS CUI [6,1])
C0205249 (UMLS CUI [6,2])
C0205257 (UMLS CUI [6,3])
Cancer treatment concomitant | Exception Male Castration | Exception Medical Castration
Item
concomitant anticancer therapy other than surgical castration or continuous medical castration.
boolean
C0920425 (UMLS CUI [1,1])
C0521115 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0007347 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C1513054 (UMLS CUI [3,2])
Restriction biological
Item
biology restriction.
boolean
C0443288 (UMLS CUI [1,1])
C0205460 (UMLS CUI [1,2])
Cardiovascular event Increases Risk Ventricular arrhythmia | Heart Disease Increases Risk Ventricular arrhythmia
Item
clinical significant cardiovascular event or presence of cardiac disease that in the opinion of the investigator increases the risk of ventricular arrhythmia.
boolean
C1320716 (UMLS CUI [1,1])
C0205217 (UMLS CUI [1,2])
C0035647 (UMLS CUI [1,3])
C0085612 (UMLS CUI [1,4])
C0018799 (UMLS CUI [2,1])
C0205217 (UMLS CUI [2,2])
C0035647 (UMLS CUI [2,3])
C0085612 (UMLS CUI [2,4])
ARRHYTHMIA SYMPTOMATIC CTCAE Grades | Treatment required for Cardiac Arrhythmia CTCAE Grades | VENTRICULAR TACHYCARDIA SYMPTOMATIC | Sustained ventricular tachycardia Asymptomatic | Pharmacotherapy Atrial Fibrillation allowed
Item
history of arrhythmia which is symptomatic or requires treatment (ctcae grade 3), symptomatic despite treatment, or asymptomatic sustained ventricular tachycardia. subjects with atrial fibrillation controlled on medication are permitted.
boolean
C0741212 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
C0332121 (UMLS CUI [2,1])
C0003811 (UMLS CUI [2,2])
C1516728 (UMLS CUI [2,3])
C0750198 (UMLS CUI [3])
C0750197 (UMLS CUI [4,1])
C0231221 (UMLS CUI [4,2])
C0013216 (UMLS CUI [5,1])
C0004238 (UMLS CUI [5,2])
C0683607 (UMLS CUI [5,3])
Uncontrolled hypertension
Item
hypertension not controlled by medical therapy
boolean
C1868885 (UMLS CUI [1])
ECG QTc interval prolonged
Item
ecg /qtc prolongation
boolean
C4272943 (UMLS CUI [1])
Left Bundle-Branch Block
Item
presence of left bundle branch block (lbbb).
boolean
C0023211 (UMLS CUI [1])