Adenocarcinoma of prostate
Item
adenocarcinoma of the prostate
boolean
C0007112 (UMLS CUI [1])
Prior Chemotherapy | Resolution Side effects Toxic
Item
resolution of acute toxic side effects of prior chemotherapy
boolean
C1514457 (UMLS CUI [1])
C1514893 (UMLS CUI [2,1])
C0879626 (UMLS CUI [2,2])
C1407029 (UMLS CUI [2,3])
Disease Resistant to Castration | Chemical male castration | Male Castration
Item
castration resistant disease despite ongoing chemical or surgical castration
boolean
C0012634 (UMLS CUI [1,1])
C0332325 (UMLS CUI [1,2])
C0007347 (UMLS CUI [1,3])
C0455189 (UMLS CUI [2])
C0007347 (UMLS CUI [3])
ECOG performance status
Item
ecog 0-1
boolean
C1520224 (UMLS CUI [1])
Prostate specific antigen measurement
Item
psa greater than or equal to 2
boolean
C0201544 (UMLS CUI [1])
Group Roman letter
Item
group a -
boolean
C0441833 (UMLS CUI [1,1])
C0439102 (UMLS CUI [1,2])
Cytotoxic Chemotherapy Absent Prostate carcinoma | Neoadjuvant Therapy allowed | Adjuvant therapy allowed
Item
no prior treatment for prostate cancer with cytotoxic chemotherapy (neoadjuvant, adjuvant treatment permitted if more than 2 years out)
boolean
C0677881 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0600139 (UMLS CUI [1,3])
C0600558 (UMLS CUI [2,1])
C0683607 (UMLS CUI [2,2])
C0677850 (UMLS CUI [3,1])
C0683607 (UMLS CUI [3,2])
Group Roman letter
Item
group b
boolean
C0441833 (UMLS CUI [1,1])
C0439102 (UMLS CUI [1,2])
Neoplasm Metastasis Radiography
Item
radiographic evidence of metastatic disease
boolean
C0027627 (UMLS CUI [1,1])
C0034571 (UMLS CUI [1,2])
Docetaxel Course Quantity Minimum | Disease Progression Prostate specific antigen measurement | Intolerance Therapeutic procedure
Item
prior tx with docetaxel-minimum of 2 cycles with progression by recist or psa or intolerant of tx
boolean
C0246415 (UMLS CUI [1,1])
C0750729 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C1524031 (UMLS CUI [1,4])
C0242656 (UMLS CUI [2,1])
C0201544 (UMLS CUI [2,2])
C0231199 (UMLS CUI [3,1])
C0087111 (UMLS CUI [3,2])
Prior Chemotherapy Quantity Maximum
Item
maximum of 3 prior chemotherapies
boolean
C1514457 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0806909 (UMLS CUI [1,3])
Small cell carcinoma of prostate
Item
small cell carcinoma of the prostate
boolean
C1300585 (UMLS CUI [1])
Molecule Treatment Approved | Molecule Treatment Investigational | Small Molecule Treatment
Item
treatment within 2 weeks with approved, investigational, or small molecule
boolean
C0567416 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
C0205540 (UMLS CUI [1,3])
C0567416 (UMLS CUI [2,1])
C0087111 (UMLS CUI [2,2])
C1517586 (UMLS CUI [2,3])
C1328819 (UMLS CUI [3,1])
C0087111 (UMLS CUI [3,2])
Biological treatment | External beam radiotherapy
Item
treatment within 4 weeks with biologic or external beam radiation
boolean
C1531518 (UMLS CUI [1])
C0419095 (UMLS CUI [2])
Absolute neutrophil count | Platelet Count measurement | Hemoglobin measurement
Item
anc <1,500 cells m3; platelets <100,000 mm3; hemoglobin <9.0g/dl
boolean
C0948762 (UMLS CUI [1])
C0032181 (UMLS CUI [2])
C0518015 (UMLS CUI [3])
Aspartate aminotransferase increased | Alanine aminotransferase increased
Item
ast/alt >2.5 uln
boolean
C0151904 (UMLS CUI [1])
C0151905 (UMLS CUI [2])
Creatinine measurement, serum
Item
serum creatinine >3.0mg/dl
boolean
C0201976 (UMLS CUI [1])
Keratitis | Keratoconjunctivitis
Item
active keratitis or keratoconjunctivitis
boolean
C0022568 (UMLS CUI [1])
C0022573 (UMLS CUI [2])
17-AAG | 17-DMAG | HSP90 Inhibitors
Item
previous treatment with 17-aag, dmag; or any other hsp-90 inhibitor
boolean
C0675974 (UMLS CUI [1])
C1527262 (UMLS CUI [2])
C0243044 (UMLS CUI [3,1])
C0243077 (UMLS CUI [3,2])
Prolonged QTc
Item
baseline qtc >450 mses
boolean
C1969409 (UMLS CUI [1])