Prostate carcinoma | Disease Progression | Status post Hormone Therapy Primary | Male Castration | Medical Castration
Item
histologically confirmed prostate carcinoma, which has proven progression after primary hormone therapy (surgical or medicinal castration).
boolean
C0600139 (UMLS CUI [1])
C0242656 (UMLS CUI [2])
C0231290 (UMLS CUI [3,1])
C0279025 (UMLS CUI [3,2])
C0205225 (UMLS CUI [3,3])
C0007347 (UMLS CUI [4])
C1513054 (UMLS CUI [5])
Serum Prostate Specific Antigen Increased Measurement Quantity
Item
patients must have increasing psa levels (within 3 months prior to enrollment) with at least two consecutively increasing psa levels.
boolean
C1883014 (UMLS CUI [1,1])
C0242485 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
Prostate specific antigen measurement
Item
psa value before inclusion must be at least 5 ng/ml
boolean
C0201544 (UMLS CUI [1])
Age
Item
at least 18 years of age.
boolean
C0001779 (UMLS CUI [1])
Able to perform self care | Waking Hour Percentage | ECOG performance status | Bone Marrow function | Laboratory Results
Item
at least capable of self care and up of at least 50% of waking hours (ecog performance status 0 - 2), adequate bone marrow function and lab results.
boolean
C2712073 (UMLS CUI [1])
C0442696 (UMLS CUI [2,1])
C0439227 (UMLS CUI [2,2])
C0439165 (UMLS CUI [2,3])
C1520224 (UMLS CUI [3])
C0005953 (UMLS CUI [4,1])
C0031843 (UMLS CUI [4,2])
C1254595 (UMLS CUI [5])
Hormone Therapy Change
Item
change of hormone therapy within 6 weeks prior inclusion
boolean
C0279025 (UMLS CUI [1,1])
C0392747 (UMLS CUI [1,2])
Prior Chemotherapy
Item
prior chemotherapy
boolean
C1514457 (UMLS CUI [1])
imatinib | Tyrosine kinase inhibitor
Item
therapy with imatinib, or therapy with other inhibitors of tyrosinkinase.
boolean
C0935989 (UMLS CUI [1])
C1268567 (UMLS CUI [2])
Second Cancer
Item
second neoplasm diagnosed within 5 years before study start.
boolean
C0751623 (UMLS CUI [1])
Warfarin Required
Item
patients who require therapy with warfarin
boolean
C0043031 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
HIV Infection | Hepatitis B | Hepatitis C
Item
known diagnosis of hiv, hepatitis b, or hepatitis c infection.
boolean
C0019693 (UMLS CUI [1])
C0019163 (UMLS CUI [2])
C0019196 (UMLS CUI [3])
Disease Severe Interferes with Diagnosis | Disease Unstable Interferes with Diagnosis | Disease Uncontrolled Interferes with Diagnosis | Disease Severe Interferes with Evaluation | Disease Unstable Interferes with Evaluation | Disease Uncontrolled Interferes with Evaluation | Heart failure Severe
Item
severe, unstable, or uncontrolled medical disease which would confound diagnoses or evaluations required by the protocol, including severe cardiac insufficiency
boolean
C0012634 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0521102 (UMLS CUI [1,3])
C0011900 (UMLS CUI [1,4])
C0012634 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0521102 (UMLS CUI [2,3])
C0011900 (UMLS CUI [2,4])
C0012634 (UMLS CUI [3,1])
C0205318 (UMLS CUI [3,2])
C0521102 (UMLS CUI [3,3])
C0011900 (UMLS CUI [3,4])
C0012634 (UMLS CUI [4,1])
C0205082 (UMLS CUI [4,2])
C0521102 (UMLS CUI [4,3])
C1261322 (UMLS CUI [4,4])
C0012634 (UMLS CUI [5,1])
C0443343 (UMLS CUI [5,2])
C0521102 (UMLS CUI [5,3])
C1261322 (UMLS CUI [5,4])
C0012634 (UMLS CUI [6,1])
C0205318 (UMLS CUI [6,2])
C0521102 (UMLS CUI [6,3])
C1261322 (UMLS CUI [6,4])
C0018801 (UMLS CUI [7,1])
C0205082 (UMLS CUI [7,2])
Operative Surgical Procedures Recently
Item
surgical therapy within 4 weeks before inclusion.
boolean
C0543467 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
Strontium Isotopes | rhenium
Item
prior therapy with isotopes strontium or rhenium.
boolean
C0038468 (UMLS CUI [1])
C0035419 (UMLS CUI [2])
Therapeutic radiology procedure Bone Marrow Percentage
Item
radiation therapy to > 25% of bone marrow within 4 weeks before inclusion.
boolean
C1522449 (UMLS CUI [1,1])
C0005953 (UMLS CUI [1,2])
C0439165 (UMLS CUI [1,3])
Experimental drug
Item
treatment with other experimental substances within 30 days before study start.
boolean
C0304229 (UMLS CUI [1])
Eligibility Criteria Study Protocol
Item
other protocol-defined inclusion/exclusion criteria may apply
boolean
C1516637 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])