Mediastinal Large B-Cell Lymphoma CD20 positive | Mass Predominant Anterior mediastinum
Item
primary mediastinal diffuse large b-cell lymphoma, cd20 positive. patients must have histological confirmation of the diagnosis, and in addition have a dominant mass within the anterior mediastinum.
boolean
C1292754 (UMLS CUI [1,1])
C3888518 (UMLS CUI [1,2])
C3273930 (UMLS CUI [2,1])
C1542147 (UMLS CUI [2,2])
C0230148 (UMLS CUI [2,3])
Prior Therapy Absent Lymphoma | Adrenal Cortex Hormones Symptoms Relief
Item
no prior treatment of lymphoma. patients may have received corticosteroids for up to 1 week for the relief of local compressive symptoms.
boolean
C1514463 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0024299 (UMLS CUI [1,3])
C0001617 (UMLS CUI [2,1])
C1457887 (UMLS CUI [2,2])
C0564405 (UMLS CUI [2,3])
Disease Stage Any
Item
any stage of disease.
boolean
C0012634 (UMLS CUI [1,1])
C1306673 (UMLS CUI [1,2])
C1552551 (UMLS CUI [1,3])
Age
Item
age at least 18 years.
boolean
C0001779 (UMLS CUI [1])
Fit Chemotherapy Curative intent
Item
fit to receive chemotherapy with curative intent.
boolean
C0424576 (UMLS CUI [1,1])
C0392920 (UMLS CUI [1,2])
C1276305 (UMLS CUI [1,3])
Informed Consent | Consent Staging | Consent Positron-Emission Tomography
Item
able and willing to give informed consent, and to undergo staging including pet scanning
boolean
C0021430 (UMLS CUI [1])
C1511481 (UMLS CUI [2,1])
C0332305 (UMLS CUI [2,2])
C1511481 (UMLS CUI [3,1])
C0032743 (UMLS CUI [3,2])
Childbearing Potential Contraceptive methods | Gender Contraceptive methods
Item
willingness to comply with an appropriate contraceptive method in women of childbearing potential or men.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2,1])
C0700589 (UMLS CUI [2,2])
Heart Disease | Ventricular arrhythmia Symptomatic | Congestive heart failure | Myocardial Infarction
Item
evidence of clinically significant cardiac disease, as defined by history of symptomatic ventricular arrhythmias, congestive heart failure or myocardial infarction within 12 months before study entry. cardiac compromise due to local extension of lymphoma will not be an exclusion criterion in the absence of other cardiac disease.
boolean
C0018799 (UMLS CUI [1])
C0085612 (UMLS CUI [2,1])
C0231220 (UMLS CUI [2,2])
C0018802 (UMLS CUI [3])
C0027051 (UMLS CUI [4])
Bone Marrow function Impairment | White Blood Cell Count procedure | Absolute neutrophil count | Platelet Count measurement | Exception Involvement with Lymphoma
Item
impairment of bone marrow function (wbc <3.0x109/l, anc <1.5x109/l, plt <100x109/l), unless due to involvement by lymphoma.
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0221099 (UMLS CUI [1,3])
C0023508 (UMLS CUI [2])
C0948762 (UMLS CUI [3])
C0032181 (UMLS CUI [4])
C1705847 (UMLS CUI [5,1])
C1314939 (UMLS CUI [5,2])
C0024299 (UMLS CUI [5,3])
Renal Insufficiency Major | Serum creatinine raised | Liver Dysfunction Major | Aspartate aminotransferase increased | Alanine aminotransferase increased | Elevated total bilirubin | Exception Involvement with Lymphoma
Item
major impairment of renal function (serum creatinine >2x upper normal) or liver function (asat/alat >2,5 upper normal, total bilirubin >2,5x upper normal), unless due to lymphoma involvement.
boolean
C1565489 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
C0700225 (UMLS CUI [2])
C0086565 (UMLS CUI [3,1])
C0205164 (UMLS CUI [3,2])
C0151904 (UMLS CUI [4])
C0151905 (UMLS CUI [5])
C0741494 (UMLS CUI [6])
C1705847 (UMLS CUI [7,1])
C1314939 (UMLS CUI [7,2])
C0024299 (UMLS CUI [7,3])
HIV Infection
Item
known hiv infection. patients will not be tested routinely.
boolean
C0019693 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
pregnant or lactating women.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Mental condition Interferes with Protocol Compliance | Condition Familial Interferes with Protocol Compliance | Sociological Factors Interfere with Protocol Compliance | Geographic Factors Interfere with Protocol Compliance
Item
any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial
boolean
C3840291 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
C0348080 (UMLS CUI [2,1])
C0241888 (UMLS CUI [2,2])
C0521102 (UMLS CUI [2,3])
C0525058 (UMLS CUI [2,4])
C3850138 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C0525058 (UMLS CUI [3,3])
C0017444 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C0525058 (UMLS CUI [4,3])