ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status of 0 to 2
boolean
C1520224 (UMLS CUI [1])
Advanced or recurrent clear cell renal cell carcinoma, prior therapy failed
Item
criteria specific for each tumor type: for clear cell renal cell carcinoma (ccrcc): advanced or recurrent disease. must have failed at least 1 prior systemic therapy
boolean
C0279702 (UMLS CUI [1,1])
C0679246 (UMLS CUI [1,2])
C1514463 (UMLS CUI [1,3])
C0231175 (UMLS CUI [1,4])
C0279702 (UMLS CUI [2,1])
C0277556 (UMLS CUI [2,2])
C1514463 (UMLS CUI [2,3])
C0231175 (UMLS CUI [2,4])
b-nhl with prior systemic therapy failed
Item
criteria specific for each tumor type: for b-cell non-hodgkin's lymphoma (b-nhl): must have failed at least 1 prior systemic therapy
boolean
C0024305 (UMLS CUI [1,1])
C1514463 (UMLS CUI [1,2])
C0231175 (UMLS CUI [1,3])
Clear cell renal cell carcinoma: measurable lesion
Item
measurable disease criteria by tumor type: for ccrcc: at least 1 unidimensional measurable lesion
boolean
C0279702 (UMLS CUI [1,1])
C1513041 (UMLS CUI [1,2])
B-nhl: measurable bidimensional lesion
Item
measurable disease criteria by tumor type: for b-nhl: at least 1 bidimensionally measurable lesion
boolean
C0024305 (UMLS CUI [1,1])
C1513041 (UMLS CUI [1,2])
C1705052 (UMLS CUI [1,3])
Prior therapy for advanced/recurrent clear cell renal cell carcinoma or relapsed/refractory b-nhl
Item
prior therapies for advanced/recurrent ccrcc or relapsed/refractory b-nhl or have become intolerant to a systemic therapy
boolean
C1514463 (UMLS CUI [1,1])
C0279702 (UMLS CUI [1,2])
C0679246 (UMLS CUI [1,3])
C1514463 (UMLS CUI [2,1])
C0279702 (UMLS CUI [2,2])
C0277556 (UMLS CUI [2,3])
C1514463 (UMLS CUI [3,1])
C0855089 (UMLS CUI [3,2])
C1514463 (UMLS CUI [4,1])
C0855090 (UMLS CUI [4,2])
C1744706 (UMLS CUI [5,1])
C1515119 (UMLS CUI [5,2])
CD70 antigen positive
Item
provide archived or fresh tumor tissue for cd70 status. subjects must be cd70+
boolean
C1514241 (UMLS CUI [1,1])
C0215991 (UMLS CUI [1,2])
Provision of fresh tumor tissue
Item
provision of fresh tissue (pre-treatment and on-treatment) for exploratory analysis is mandatory for at least 5 and a maximum of 10 b-nhl subjects
boolean
C1292533 (UMLS CUI [1,1])
C2827486 (UMLS CUI [1,2])
Prior therapy with an anti-cd70 antibody
Item
prior therapy with an anti-cd70 antibody
boolean
C1514463 (UMLS CUI [1,1])
C0281176 (UMLS CUI [1,2])
C0215991 (UMLS CUI [1,3])
Hypersensitivity to monoclonal antibodies
Item
history of severe hypersensitivity reactions to other monoclonal antibodies
boolean
C0020517 (UMLS CUI [1,1])
C0003250 (UMLS CUI [1,2])
CNS lymphoma
Item
active or untreated central nervous system lymphoma
boolean
C0280803 (UMLS CUI [1])
Infection
Item
active infection (viral, bacterial, or fungal)
boolean
C3714514 (UMLS CUI [1])
Bleeding diathesis or coagulopathy
Item
evidence of bleeding diathesis or coagulopathy
boolean
C0005779 (UMLS CUI [1])
Concomitant autoimmune disease
Item
active autoimmune disease requiring immunosuppressive therapy
boolean
C0021079 (UMLS CUI [1,1])
C0004364 (UMLS CUI [1,2])
Substance abuse
Item
known current drug or alcohol abuse
boolean
C0013146 (UMLS CUI [1])
C0085762 (UMLS CUI [2])