Parkinson Disease
Item
1. a clinical diagnosis of idiopathic pd by a movement disorders specialist. all subjects will be diagnosed using the uk brain bank criteria (hughes et al., 1992).
boolean
C0030567 (UMLS CUI [1])
Age
Item
2. age between 40-85 years.
boolean
C0001779 (UMLS CUI [1])
Informed Consent | Protocol Compliance
Item
3. able to sign and understand informed consent; and cognitively able to carry out the procedures in the study
boolean
C0021430 (UMLS CUI [1])
C0525058 (UMLS CUI [2])
Antiparkinson Agents Stable | Psychotropic Drugs Stable
Item
4. stable on all pd medications for at least 30 days; and psychotropic medications for at least 90 days.
boolean
C0003405 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
C0033978 (UMLS CUI [2,1])
C0205360 (UMLS CUI [2,2])
Study Subject Therapy naive | Under consideration Monoamine Oxidase Inhibitors Parkinson Disease
Item
5. treatment naïve subjects who are appropriate candidates to begin mao-inhibitor monotherapy as treatment for their pd may also be included in this study.
boolean
C0681850 (UMLS CUI [1,1])
C0919936 (UMLS CUI [1,2])
C1272681 (UMLS CUI [2,1])
C0026457 (UMLS CUI [2,2])
C0030567 (UMLS CUI [2,3])
Fatigue Severity Scale
Item
6. fatigue severity scale ≥ 36 (krupps et al., 1989)
boolean
C3813323 (UMLS CUI [1])
Disease Associated with Fatigue | Heart Diseases | Lung diseases | Anemia | Sleep Apnea, Obstructive | Liver Failure | Kidney Failure
Item
1. clinically significant medical disease that is associated independently with fatigue (e.g. significant cardiac or pulmonary disease, anemia, obstructive sleep apnea, liver or kidney failure).
boolean
C0012634 (UMLS CUI [1,1])
C0332281 (UMLS CUI [1,2])
C0015672 (UMLS CUI [1,3])
C0018799 (UMLS CUI [2])
C0024115 (UMLS CUI [3])
C0002871 (UMLS CUI [4])
C0520679 (UMLS CUI [5])
C0085605 (UMLS CUI [6])
C0035078 (UMLS CUI [7])
Nervous system disorder | Exception Parkinson Disease | Craniocerebral Trauma | Unconscious State
Item
2. history of neurological illnesses other than pd or a history of a significant head trauma (involving unconsciousness).
boolean
C0027765 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0030567 (UMLS CUI [2,2])
C0018674 (UMLS CUI [3])
C0041657 (UMLS CUI [4])
Secondary Parkinson Disease | Atypical Parkinsonism | Cerebrovascular accident | Exposure to Toxins | Exposure to Antipsychotic Agents | Encephalitis | Neurologic Signs Upper Motor Neuron Disease | Involvement Cerebellar | Supranuclear gaze palsy | Hypotension, Orthostatic
Item
3. evidence of secondary or atypical parkinsonism as suggested by the presence of any of the following: 1) history of stroke(s), 2) exposure to toxins or neuroleptics, 3) history of encephalitis, 4) neurological signs of upper motor neuron disease, cerebellar involvement, supranuclear gaze palsy, or significant orthostatic hypotension.
boolean
C0030569 (UMLS CUI [1])
C4302185 (UMLS CUI [2])
C0038454 (UMLS CUI [3])
C0332157 (UMLS CUI [4,1])
C0040549 (UMLS CUI [4,2])
C0332157 (UMLS CUI [5,1])
C0040615 (UMLS CUI [5,2])
C0014038 (UMLS CUI [6])
C0751378 (UMLS CUI [7,1])
C0521659 (UMLS CUI [7,2])
C1314939 (UMLS CUI [8,1])
C0007765 (UMLS CUI [8,2])
C1720037 (UMLS CUI [9])
C0020651 (UMLS CUI [10])
Cerebral atrophy MRI | Cerebral atrophy CT scan | Abnormality of brain MRI | Abnormality of brain CT scan | Infarction, Lacunar | Iron Deposits Putamen
Item
4. mri or ct scan with significant evidence of brain atrophy or other abnormalities (e.g. lacunar infarcts or iron deposits in the putamen.
boolean
C0235946 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])
C0235946 (UMLS CUI [2,1])
C0040405 (UMLS CUI [2,2])
C4021085 (UMLS CUI [3,1])
C0024485 (UMLS CUI [3,2])
C4021085 (UMLS CUI [4,1])
C0040405 (UMLS CUI [4,2])
C0333559 (UMLS CUI [5])
C0302583 (UMLS CUI [6,1])
C0333562 (UMLS CUI [6,2])
C1281335 (UMLS CUI [6,3])
Dementia | Mini-mental state examination
Item
5. clinical diagnoses of dementia; or an mmse score of < 25.
boolean
C0497327 (UMLS CUI [1])
C0451306 (UMLS CUI [2])
Mental disorder Major Unstable | Mental disorder Major Newly Diagnosed | Mental disorder Major Treated | Depressive disorder | Anxiety
Item
6. unstable, newly diagnosed, or newly treated (i.e. less than 3 months) major psychiatric disorder such as depression or anxiety
boolean
C0004936 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
C0443343 (UMLS CUI [1,3])
C0004936 (UMLS CUI [2,1])
C0205164 (UMLS CUI [2,2])
C1518321 (UMLS CUI [2,3])
C0004936 (UMLS CUI [3,1])
C0205164 (UMLS CUI [3,2])
C1522326 (UMLS CUI [3,3])
C0011581 (UMLS CUI [4])
C0003467 (UMLS CUI [5])
Beck depression inventory score
Item
7. beck's depression inventory score >14.
boolean
C2960571 (UMLS CUI [1])
Deep brain stimulator implant
Item
8. current or prior placement of deep brain stimulator.
boolean
C4069029 (UMLS CUI [1])
MAO-B Inhibitors | Pharmaceutical Preparations Fatigue | Amantadine | modafinil | Methylphenidate | atomoxetine | Psychostimulant
Item
9. currently taking an mao-b inhibitor or medications which are used as fatigue treatments, including amantadine, modafinil, methylphenidate, atomoxetine or other psychostimulants.
boolean
C4020574 (UMLS CUI [1])
C0013227 (UMLS CUI [2,1])
C0015672 (UMLS CUI [2,2])
C0002403 (UMLS CUI [3])
C0066677 (UMLS CUI [4])
C0025810 (UMLS CUI [5])
C0076823 (UMLS CUI [6])
C0304403 (UMLS CUI [7])
MAO-B Inhibitors In the past
Item
10. previously taken an mao-b inhibitor for more than 2 weeks.
boolean
C4020574 (UMLS CUI [1,1])
C1444637 (UMLS CUI [1,2])
Hypersensitivity Rasagiline
Item
11. hypersensitivity to rasagiline or its products
boolean
C0020517 (UMLS CUI [1,1])
C0525678 (UMLS CUI [1,2])
Mirtazapine | venlafaxine | Vasoconstrictor Agents Regular | Tramadol | Meperidine | Propoxyphene | Dextromethorphan | ST. JOHN'S WORT EXTRACT | cyclobenzaprine
Item
12. on mirtazapine, venlafaxine, regular use of compounds with vasoconstrictors, tramadol, meperidine, propoxyphene, dextromethorphan, st. john's wort, cyclobenzaprine
boolean
C0049506 (UMLS CUI [1])
C0078569 (UMLS CUI [2])
C0042397 (UMLS CUI [3,1])
C0205272 (UMLS CUI [3,2])
C0040610 (UMLS CUI [4])
C0025376 (UMLS CUI [5])
C0033493 (UMLS CUI [6])
C0011816 (UMLS CUI [7])
C0813171 (UMLS CUI [8])
C0056732 (UMLS CUI [9])
Omeprazole | Ciprofloxacin | Pharmaceutical Preparations Metabolism CYP1A2
Item
13. on omeprazole, ciprofloxacin or drugs that are metabolized through cyp1a2
boolean
C0028978 (UMLS CUI [1])
C0008809 (UMLS CUI [2])
C0013227 (UMLS CUI [3,1])
C2698779 (UMLS CUI [3,2])
C0207509 (UMLS CUI [3,3])