Parkinson Disease | Signs Main Quantity | Bradykinesia | Resting Tremor | Muscle Rigidity | Absence Cause Other Parkinsonian Disorders | Absence Signs Atypical Parkinsonism
Item
men and women with parkinson's disease (pd), defined as the presence of at least two of the cardinal signs of pd (bradykinesia, resting tremor, rigidity) without other identifiable cause of parkinsonism or signs of atypical parkinsonism
boolean
C0030567 (UMLS CUI [1])
C0311392 (UMLS CUI [2,1])
C1542147 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
C0233565 (UMLS CUI [3])
C0234379 (UMLS CUI [4])
C0026837 (UMLS CUI [5])
C0332197 (UMLS CUI [6,1])
C0015127 (UMLS CUI [6,2])
C0205394 (UMLS CUI [6,3])
C0242422 (UMLS CUI [6,4])
C0332197 (UMLS CUI [7,1])
C0311392 (UMLS CUI [7,2])
C4302185 (UMLS CUI [7,3])
Hyposmia Functional | Anosmia Functional | Smell Identification Test Score
Item
functional hyposmia or anosmia, as defined by upsit scores less than the 25th percentile for age- and gender-matched norms
boolean
C2364082 (UMLS CUI [1,1])
C0205245 (UMLS CUI [1,2])
C0003126 (UMLS CUI [2,1])
C0205245 (UMLS CUI [2,2])
C0037361 (UMLS CUI [3,1])
C0205396 (UMLS CUI [3,2])
C0039593 (UMLS CUI [3,3])
C0449820 (UMLS CUI [3,4])
Antiparkinson Agents Dose Stable
Item
have been on stable dose of pd medications for at least 30 days
boolean
C0003405 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
Age
Item
age < or = 90 years
boolean
C0001779 (UMLS CUI [1])
Informed Consent
Item
willing and able to give informed consent
boolean
C0021430 (UMLS CUI [1])
Childbearing Potential Contraceptive methods | Childbearing Potential Pregnancy test negative | Childbearing Potential Breast Feeding Absent
Item
women of child-bearing potential may participate provided they are willing to use adequate contraceptive methods during the duration of the study. women of childbearing potential must have a negative pregnancy test at the screening visit and be non-lactating.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C3831118 (UMLS CUI [2,1])
C0427780 (UMLS CUI [2,2])
C3831118 (UMLS CUI [3,1])
C0006147 (UMLS CUI [3,2])
C0332197 (UMLS CUI [3,3])
Monoamine Oxidase Inhibitors | Selegiline | rasagiline
Item
prior use of an mao inhibitor, including selegiline or rasagiline within the last 12 months
boolean
C0026457 (UMLS CUI [1])
C0036579 (UMLS CUI [2])
C0525678 (UMLS CUI [3])
Condition Causing Olfactory impairment | Craniocerebral Trauma | Operation on nose | Nasal inflammation Causing Congestion | Nasal inflammation Causing Polyps | Nasal infection | Sinusitis | Zinc salts Intranasal | Zicam | Tobacco use
Item
presence of other conditions that in the investigator's opinion may significantly cause olfactory impairment, including prior head trauma, nasal surgery, nasal inflammation causing concurrent congestion or polyps, nasal or sinus infection, prior intranasal zinc salt (zicam) use, history of smoking within the past year
boolean
C0348080 (UMLS CUI [1,1])
C0678227 (UMLS CUI [1,2])
C1510410 (UMLS CUI [1,3])
C0018674 (UMLS CUI [2])
C0188970 (UMLS CUI [3])
C2718128 (UMLS CUI [4,1])
C0678227 (UMLS CUI [4,2])
C0700148 (UMLS CUI [4,3])
C2718128 (UMLS CUI [5,1])
C0678227 (UMLS CUI [5,2])
C0032584 (UMLS CUI [5,3])
C0555970 (UMLS CUI [6])
C0037199 (UMLS CUI [7])
C0351669 (UMLS CUI [8,1])
C0001560 (UMLS CUI [8,2])
C3855401 (UMLS CUI [9])
C0543414 (UMLS CUI [10])
Dementia Mini-mental state examination | Impaired cognition Mini-mental state examination
Item
presence of dementia or significant cognitive impairment with mini-mental state examination (mmse) < 24
boolean
C0497327 (UMLS CUI [1,1])
C0451306 (UMLS CUI [1,2])
C0338656 (UMLS CUI [2,1])
C0451306 (UMLS CUI [2,2])
Medical condition Study Subject Participation Status Excluded | Operative Surgical Procedures Study Subject Participation Status Excluded | Medical condition Excludes Completion of clinical trial | Operative Surgical Procedures Exclude Completion of clinical trial
Item
present of a medical or surgical condition which in the opinion of the investigator would preclude participation in and completion of study procedures
boolean
C3843040 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C0332196 (UMLS CUI [1,3])
C0543467 (UMLS CUI [2,1])
C2348568 (UMLS CUI [2,2])
C0332196 (UMLS CUI [2,3])
C3843040 (UMLS CUI [3,1])
C0332196 (UMLS CUI [3,2])
C2732579 (UMLS CUI [3,3])
C0543467 (UMLS CUI [4,1])
C0332196 (UMLS CUI [4,2])
C2732579 (UMLS CUI [4,3])
Experimental drug
Item
use of any experimental medication within 60 days of baseline
boolean
C0304229 (UMLS CUI [1])
Decongestants | Antihistamines | Inhaled steroids use
Item
use of decongestants, antihistamines, inhaled steroids within 2 weeks of baseline
boolean
C0282374 (UMLS CUI [1])
C0003360 (UMLS CUI [2])
C0586793 (UMLS CUI [3])
Pharmaceutical Preparations Contraindicated Rasagiline
Item
use of any medication contraindicated with use of rasagiline (investigator will take into consideration concomitant antidepressant use as per prescribing information guidelines for rasagiline)
boolean
C0013227 (UMLS CUI [1,1])
C1444657 (UMLS CUI [1,2])
C0525678 (UMLS CUI [1,3])