Age
Item
1. 35-80 year old men & women
boolean
C0001779 (UMLS CUI [1])
Parkinson Disease | Parkinsonian Disorders | Healthy Control | Study Subject Diagnosis Except Neurodegenerative Disorders | Study Subject General health good
Item
2. patients with ipd or parkinsonian syndromes, or controls consisting of healthy subjects, or subjects who have a non-neurodegenerative diagnosis but are otherwise healthy.
boolean
C0030567 (UMLS CUI [1])
C0242422 (UMLS CUI [2])
C2986479 (UMLS CUI [3])
C0681850 (UMLS CUI [4,1])
C0011900 (UMLS CUI [4,2])
C0332300 (UMLS CUI [4,3])
C0524851 (UMLS CUI [4,4])
C0681850 (UMLS CUI [5,1])
C1277245 (UMLS CUI [5,2])
Informed Consent
Item
3. gives written informed consent
boolean
C0021430 (UMLS CUI [1])
Pregnancy Identified HCG pregnancy test
Item
4. pregnant women are not excluded, but will be identified by hcg.
boolean
C0032961 (UMLS CUI [1,1])
C0205396 (UMLS CUI [1,2])
C0546577 (UMLS CUI [1,3])
Parkinsonian symptoms | Etiology Absent Idiopathic Parkinson Disease | Etiology Absent Sporadic Parkinson disease | Medication-induced parkinsonism | Parkinsonian symptoms Toxic substance Induced | Atypical Parkinsonism
Item
1. parkinsonian symptoms not due to idiopathic (sporadic) pd, such as those that are medication induced, toxic substance induced or representative of an atypical parkinsonian syndrome will be categorized separately.
boolean
C0242422 (UMLS CUI [1])
C0015127 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0030567 (UMLS CUI [2,3])
C0015127 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C4511452 (UMLS CUI [3,3])
C4237315 (UMLS CUI [4])
C0242422 (UMLS CUI [5,1])
C0032346 (UMLS CUI [5,2])
C0205263 (UMLS CUI [5,3])
C4302185 (UMLS CUI [6])
Medical condition Unstable | Medical condition Uncontrolled | Mental condition Unstable | Mental condition Uncontrolled
Item
2. any unstable or uncontrolled medical or psychiatric condition.
boolean
C3843040 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
C3843040 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
C3840291 (UMLS CUI [3,1])
C0443343 (UMLS CUI [3,2])
C3840291 (UMLS CUI [4,1])
C0205318 (UMLS CUI [4,2])
Renal Insufficiency | Creatinine measurement, serum | Hepatic Insufficiency | Increased liver function tests | Heart Diseases
Item
3. renal (creatinine over 1.6) or hepatic insufficiency (lft three-fold higher than normal range), or a history of significant cardiac disease.
boolean
C1565489 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
C1306571 (UMLS CUI [3])
C0877359 (UMLS CUI [4])
C0018799 (UMLS CUI [5])
Blood Coagulation Disorders | Plavix | Aggrenox | Heparin | Coumadin | Aspirin Dose Large | Pharmaceutical Preparations Discontinue Ability | Blood coagulation Value Stable | Status pre- Lumbar puncture
Item
4. if there is a history or evidence of coagulopathy, on medications such as plavix, aggrenox, heparin, coumadin, or large doses of aspirin, must be able to remain off these medications for at least 3 days, and have stable blood coagulation values prior to any lumbar puncture (lp).
boolean
C0005779 (UMLS CUI [1])
C0633084 (UMLS CUI [2])
C0732282 (UMLS CUI [3])
C0019134 (UMLS CUI [4])
C0699129 (UMLS CUI [5])
C0004057 (UMLS CUI [6,1])
C0178602 (UMLS CUI [6,2])
C0549177 (UMLS CUI [6,3])
C0013227 (UMLS CUI [7,1])
C1444662 (UMLS CUI [7,2])
C0085732 (UMLS CUI [7,3])
C0005778 (UMLS CUI [8,1])
C1522609 (UMLS CUI [8,2])
C0205360 (UMLS CUI [8,3])
C0332152 (UMLS CUI [9,1])
C0553794 (UMLS CUI [9,2])
Dementia Mini-mental state examination | Dementia Montreal cognitive assessment | Dementia Interferes with Study Protocol | Dementia Interferes with Informed Consent
Item
5. significant dementia (mmse<25/30 or moca<25/30) that would interfere with study procedures or the giving of informed consent for the study .
boolean
C0497327 (UMLS CUI [1,1])
C0451306 (UMLS CUI [1,2])
C0497327 (UMLS CUI [2,1])
C3496286 (UMLS CUI [2,2])
C0497327 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C2348563 (UMLS CUI [3,3])
C0497327 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C0021430 (UMLS CUI [4,3])
Communicable Diseases | Skin Diseases, Infectious | Respiratory Tract Infections | Gastrointestinal infection | HIV Seropositivity | Lumbar puncture
Item
6. active infections including skin, respiratory or gi infections, and hiv+ (if undergoing an lp).
boolean
C0009450 (UMLS CUI [1])
C0037278 (UMLS CUI [2])
C0035243 (UMLS CUI [3])
C4082764 (UMLS CUI [4])
C0019699 (UMLS CUI [5])
C0553794 (UMLS CUI [6])
Neurodegenerative Disorders | Alzheimer's Disease | Huntington Disease
Item
7. any evidence of a different neurodegenerative disorder, for example, alzheimer's disease or huntington's disease.
boolean
C0524851 (UMLS CUI [1])
C0002395 (UMLS CUI [2])
C0020179 (UMLS CUI [3])
fMRI | Reason Identified Screening questionnaire
Item
8. fmri will not be performed is screening questionnaire identifies a reason.
boolean
C0376335 (UMLS CUI [1])
C0392360 (UMLS CUI [2,1])
C0205396 (UMLS CUI [2,2])
C1134635 (UMLS CUI [2,3])