Age
Item
subjects aged 18 years or over
boolean
C0001779 (UMLS CUI [1])
Parkinson Disease Advanced | Hypomobility Disabling | Apokyn Subcutaneous Injections
Item
subjects with advanced parkinson's disease with disabling hypomobility ("off" episodes) who are to be initiated with apokyn® by intermittent subcutaneous injection
boolean
C0030567 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C0391852 (UMLS CUI [2,1])
C4061999 (UMLS CUI [2,2])
C1589388 (UMLS CUI [3,1])
C0021499 (UMLS CUI [3,2])
Able to swallow Tigan | Able to swallow Placebo capsule
Item
able to swallow tigan®/placebo capsules
boolean
C2712086 (UMLS CUI [1,1])
C0733768 (UMLS CUI [1,2])
C2712086 (UMLS CUI [2,1])
C1696465 (UMLS CUI [2,2])
C0006935 (UMLS CUI [2,3])
Protocol Compliance
Item
subjects willing and able to comply with scheduled visits, treatment plan, laboratory tests and other study procedures
boolean
C0525058 (UMLS CUI [1])
Childbearing Potential Pregnancy test negative beta hcg serum | Childbearing Potential Contraceptive methods
Item
women of child bearing potential must have a negative serum pregnancy test (beta hcg) prior to receiving study drug and must be using an appropriate form of contraception
boolean
C3831118 (UMLS CUI [1,1])
C0427780 (UMLS CUI [1,2])
C0741474 (UMLS CUI [1,3])
C3831118 (UMLS CUI [2,1])
C0700589 (UMLS CUI [2,2])
Informed Consent
Item
willing and able to provide informed consent
boolean
C0021430 (UMLS CUI [1])
Hypersensitivity Apomorphine hydrochloride | Hypersensitivity Apokyn Ingredient
Item
hypersensitive to apomorphine hydrochloride or any of the ingredients of apokyn®
boolean
C0020517 (UMLS CUI [1,1])
C0237406 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C1589388 (UMLS CUI [2,2])
C1550600 (UMLS CUI [2,3])
sodium metabisulfite
Item
(notably sodium metabisulfite)
boolean
C0074744 (UMLS CUI [1])
Hypersensitivity Trimethobenzamide | Hypersensitivity Tigan Ingredient
Item
hypersensitive to trimethobenzamide or any of the ingredients of tigan®
boolean
C0020517 (UMLS CUI [1,1])
C0077163 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0733768 (UMLS CUI [2,2])
C1550600 (UMLS CUI [2,3])
Apokyn
Item
previous treatment with apokyn®
boolean
C1589388 (UMLS CUI [1])
Study Subject Participation Status
Item
participation in any other clinical trial within 14 days of the present trial
boolean
C2348568 (UMLS CUI [1])
Medical contraindication Apokyn | Medical contraindication Tigan
Item
contraindications to apokyn® or tigan®
boolean
C1301624 (UMLS CUI [1,1])
C1589388 (UMLS CUI [1,2])
C1301624 (UMLS CUI [2,1])
C0733768 (UMLS CUI [2,2])
5HT3 Receptor Antagonists | Patient need for Probably 5HT3 Receptor Antagonists | Ondansetron | Alosetron | Granisetron | Palonosetron | Dolasetron
Item
currently taking, or likely to need to take at any time during the course of the study, any 5ht3 antagonist (ondansetron, alosetron, granisetron, palonosetron or dolasetron)
boolean
C2917245 (UMLS CUI [1])
C0686904 (UMLS CUI [2,1])
C0750492 (UMLS CUI [2,2])
C2917245 (UMLS CUI [2,3])
C0061851 (UMLS CUI [3])
C0291772 (UMLS CUI [4])
C0061863 (UMLS CUI [5])
C0220578 (UMLS CUI [6])
C0209210 (UMLS CUI [7])
Melanoma | Melanoma Treated
Item
malignant melanoma or a history of previously treated malignant melanoma
boolean
C0025202 (UMLS CUI [1])
C0025202 (UMLS CUI [2,1])
C1522326 (UMLS CUI [2,2])
Pregnancy | Breast Feeding
Item
pregnancy or breast feeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Investigational New Drugs
Item
receipt of any investigational (i.e. unapproved) medication within 30 days of starting the present trial
boolean
C0013230 (UMLS CUI [1])
Disease Study Subject Participation Status Hazard | Medical condition Study Subject Participation Status Hazard | Pharmaceutical Preparations Study Subject Participation Status Hazard | Mental disorders Study Subject Participation Status Hazard | Disease Preventing Completion of clinical trial | Medical condition Preventing Completion of clinical trial | Pharmaceutical Preparations Preventing Completion of clinical trial | Mental disorders Preventing Completion of clinical trial
Item
any significant medical disorder, condition, concomitant medication or psychiatric disorder according to dsm-iv criteria which would, in the opinion of the investigator, represent a hazard to the subject or prevent the subject from completing the trial
boolean
C0012634 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C0598697 (UMLS CUI [1,3])
C3843040 (UMLS CUI [2,1])
C2348568 (UMLS CUI [2,2])
C0598697 (UMLS CUI [2,3])
C0013227 (UMLS CUI [3,1])
C2348568 (UMLS CUI [3,2])
C0598697 (UMLS CUI [3,3])
C0004936 (UMLS CUI [4,1])
C2348568 (UMLS CUI [4,2])
C0598697 (UMLS CUI [4,3])
C0012634 (UMLS CUI [5,1])
C1292733 (UMLS CUI [5,2])
C2732579 (UMLS CUI [5,3])
C3843040 (UMLS CUI [6,1])
C1292733 (UMLS CUI [6,2])
C2732579 (UMLS CUI [6,3])
C0013227 (UMLS CUI [7,1])
C1292733 (UMLS CUI [7,2])
C2732579 (UMLS CUI [7,3])
C0004936 (UMLS CUI [8,1])
C1292733 (UMLS CUI [8,2])
C2732579 (UMLS CUI [8,3])