Age | Parkinson Disease Levodopa-responsive
Item
men and women aged 40 to 80 years with dopa-responsive pd
boolean
C0001779 (UMLS CUI [1])
C0030567 (UMLS CUI [2,1])
C1853846 (UMLS CUI [2,2])
Hoehn and Yahr grades
Item
hoehn and yahr grade of 2 to 4 while off
boolean
C0451215 (UMLS CUI [1])
Therapeutic procedure Including Levodopa
Item
must be on a regimen including levodopa.
boolean
C0087111 (UMLS CUI [1,1])
C0332257 (UMLS CUI [1,2])
C0023570 (UMLS CUI [1,3])
Levodopa | Dopamine Agonists | Dopamine Equivalent | Total Dose U/day
Item
total dose of levodopa and dopamine agonists (using dopamine equivalents) has to be equal to or more than 300 milligrams per day
boolean
C0023570 (UMLS CUI [1])
C0178601 (UMLS CUI [2])
C0013030 (UMLS CUI [3,1])
C0205163 (UMLS CUI [3,2])
C2986497 (UMLS CUI [4,1])
C0456683 (UMLS CUI [4,2])
Difficulty walking | Freezing of gait Time Distance
Item
problems with walking, including freezing gait time for a 10-meter distance greater than six seconds or more
boolean
C0311394 (UMLS CUI [1])
C0860515 (UMLS CUI [2,1])
C0040223 (UMLS CUI [2,2])
C0012751 (UMLS CUI [2,3])
Mental disorder | Dementia
Item
any active psychiatric disease or evidence of dementia
boolean
C0004936 (UMLS CUI [1])
C0497327 (UMLS CUI [2])
Seizures | Epilepsy
Item
history of seizures and epilepsy
boolean
C0036572 (UMLS CUI [1])
C0014544 (UMLS CUI [2])
Tricyclic Antidepressive Agents | Antipsychotic Agents | Pharmaceutical Preparations Lowered convulsive threshold | Exception Antiparkinson Agents | Exception SSRI
Item
concurrent use of tricyclic antidepressants, neuroleptic agents, or any other licit or illicit drugs other than anti-parkinsonian agents that could lower the seizure threshold except for ssri
boolean
C0003290 (UMLS CUI [1])
C0040615 (UMLS CUI [2])
C0013227 (UMLS CUI [3,1])
C0234976 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0003405 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C0360105 (UMLS CUI [5,2])
Pallidotomy | Electrodes, Implanted | Deep brain stimulator
Item
pallidotomy, implanted electrodes and generator for deep brain stimulation
boolean
C0195893 (UMLS CUI [1])
C0013814 (UMLS CUI [2])
C4069029 (UMLS CUI [3])
Pregnancy
Item
pregnancy
boolean
C0032961 (UMLS CUI [1])
Implants | Artificial cardiac pacemaker | Pump Implanted | Hearing Aids Implanted | Plates, Cranioplasty | Metallic implant Skull | Metallic implant Eye
Item
surgically or traumatically implanted foreign bodies such as a pacemaker, implanted medical pump, implanted hearing aids, metal plate in the skull, or metal implant in the skull or eyes (other than dental appliances or fillings) that may pose a physical hazard during tep.
boolean
C0021102 (UMLS CUI [1])
C0030163 (UMLS CUI [2])
C0182537 (UMLS CUI [3,1])
C0021102 (UMLS CUI [3,2])
C0018768 (UMLS CUI [4,1])
C0021102 (UMLS CUI [4,2])
C0182313 (UMLS CUI [5])
C3693688 (UMLS CUI [6,1])
C2951888 (UMLS CUI [6,2])
C3693688 (UMLS CUI [7,1])
C0015392 (UMLS CUI [7,2])
Study Subject Participation Status At risk | Tendency to fall | Fatigue Excessive | Frailty General | Apprehensiveness Excessive
Item
study would cause undue risk or stress for reasons such as tendency to fall, excessive fatigue, general frailty, or excessive apprehensiveness.
boolean
C2348568 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C2830327 (UMLS CUI [2])
C0015672 (UMLS CUI [3,1])
C0442802 (UMLS CUI [3,2])
C0424594 (UMLS CUI [4,1])
C0205246 (UMLS CUI [4,2])
C0233485 (UMLS CUI [5,1])
C0442802 (UMLS CUI [5,2])
Dementia Mini-mental state examination | Mental impairment | Informed Consent Unable
Item
dementia as assessed by the folstein's mini-mental test examination (mmse less than or equal to 24/30) or mentally impaired patients having no capacity to provide their own consent (the physician establishing the diagnosis and applying updrs will evaluate patient's mental capacity using conventional clinical interview)
boolean
C0497327 (UMLS CUI [1,1])
C0451306 (UMLS CUI [1,2])
C0683322 (UMLS CUI [2])
C0021430 (UMLS CUI [3,1])
C1299582 (UMLS CUI [3,2])
Lacking Able to walk Meter Quantity
Item
unable to walk a 10-meter distance.
boolean
C0332268 (UMLS CUI [1,1])
C2712089 (UMLS CUI [1,2])
C0475209 (UMLS CUI [1,3])
C1265611 (UMLS CUI [1,4])
Falls Daily UPDRS | History of fall | Injuries | Absence of postural response | Impairment of balance UPDRS
Item
more than occasional falls, i.e. daily falls (corresponding to a score greater than or equal to 3 and more in updrs item 13), history of fall(s) with significant injuries, absence of postural response in the on condition and/or spontaneous loss of balance in the off condition (corresponding to a score of greater than or equal to 2 and greater than or equal to 3 in on/off condition, respectively, in updrs item 30)
boolean
C0000921 (UMLS CUI [1,1])
C0332173 (UMLS CUI [1,2])
C3639721 (UMLS CUI [1,3])
C1561668 (UMLS CUI [2])
C3263723 (UMLS CUI [3])
C4036289 (UMLS CUI [4])
C0241981 (UMLS CUI [5,1])
C3639721 (UMLS CUI [5,2])
Childbearing Potential Urine pregnancy test | Childbearing Potential Contraceptive methods
Item
pregnancy is unusual in patients with pd, grade 2-4. urine sample for the pregnancy test will be obtained in patients of childbearing potential prior to the itbs start, at the day of the initial interview and signing the consent form. women of childbearing potential will be asked to take appropriate measures to prevent a pregnancy during the study.
boolean
C3831118 (UMLS CUI [1,1])
C0430056 (UMLS CUI [1,2])
C3831118 (UMLS CUI [2,1])
C0700589 (UMLS CUI [2,2])