Healthy Control Inclusion criteria
Item
health control:
boolean
C2986479 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
Age
Item
the subject is aged 18-70.
boolean
C0001779 (UMLS CUI [1])
Informed Consent
Item
written informed consent is obtained.
boolean
C0021430 (UMLS CUI [1])
Laboratory Results Clinical Significance Absent | Illness Unstable Absent | Nervous system disorder Unstable Absent | Mental disorders Unstable Absent
Item
the participant has no clinically significant clinical laboratory value and/or clinically significant unstable medical, neurological or psychiatric illness.
boolean
C1254595 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
C0221423 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
C0027765 (UMLS CUI [3,1])
C0443343 (UMLS CUI [3,2])
C0332197 (UMLS CUI [3,3])
C0004936 (UMLS CUI [4,1])
C0443343 (UMLS CUI [4,2])
C0332197 (UMLS CUI [4,3])
Gender | Childbearing Potential Absent | Urine pregnancy test negative | Other Coding
Item
for females, non-child bearing potential or negative urine pregnancy test on day of [123i] mzint injection.
boolean
C0079399 (UMLS CUI [1])
C3831118 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0430057 (UMLS CUI [3])
C3846158 (UMLS CUI [4])
Protocol Compliance
Item
willingness to comply with the study protocol
boolean
C0525058 (UMLS CUI [1])
Parkinson Disease Inclusion criteria
Item
parkinson disease:
boolean
C0030567 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
Age
Item
the subject is aged 18-70.
boolean
C0001779 (UMLS CUI [1])
Parkinson Disease | Symptoms Main Quantity | Resting Tremor | Muscle Rigidity | Bradykinesia
Item
participants have a clinical diagnosis (at least two of the three cardinal symptoms: resting tremor, rigidity, bradykinesia) of idiopathic parkinson's disease.
boolean
C0030567 (UMLS CUI [1])
C1457887 (UMLS CUI [2,1])
C1542147 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
C0234379 (UMLS CUI [3])
C0026837 (UMLS CUI [4])
C0233565 (UMLS CUI [5])
Hoehn and Yahr Stage
Item
hoehn and yahr stages < 3.
boolean
C3639483 (UMLS CUI [1])
Informed Consent
Item
written informed consent is obtained.
boolean
C0021430 (UMLS CUI [1])
Laboratory Results Clinical Significance Absent | Illness Unstable Absent | Nervous system disorder Unstable Absent | Mental disorders Unstable Absent
Item
the participant has no clinically significant clinical laboratory value and/or clinically significant unstable medical, neurological or psychiatric illness.
boolean
C1254595 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
C0221423 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
C0027765 (UMLS CUI [3,1])
C0443343 (UMLS CUI [3,2])
C0332197 (UMLS CUI [3,3])
C0004936 (UMLS CUI [4,1])
C0443343 (UMLS CUI [4,2])
C0332197 (UMLS CUI [4,3])
Gender | Childbearing Potential Absent | Urine pregnancy test negative | Other Coding
Item
for females, non-child bearing potential or negative urine pregnancy test on day of [123i] mzint injection.
boolean
C0079399 (UMLS CUI [1])
C3831118 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0430057 (UMLS CUI [3])
C3846158 (UMLS CUI [4])
Protocol Compliance
Item
willingness to comply with the study protocol
boolean
C0525058 (UMLS CUI [1])
Study Subject Participation Status Excluded
Item
all subjects will be excluded from participation for the following reasons:
boolean
C2348568 (UMLS CUI [1,1])
C0332196 (UMLS CUI [1,2])
Laboratory test result abnormal | Illness | Mental disorders
Item
the subject has a clinically significant clinical laboratory values abnormality, and/or medical or psychiatric illness.
boolean
C0438215 (UMLS CUI [1])
C0221423 (UMLS CUI [2])
C0004936 (UMLS CUI [3])
Disease Interferes with Drug absorption | Disease Interferes with Drug distribution | Disease Interferes with Drug metabolism | Disease Interferes with Drug elimination | Gastrointestinal Surgical Procedure
Item
the subject has any disorder that may interfere with drug absorption, distribution, metabolism, or excretion (including gastrointestinal surgery).
boolean
C0012634 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0678745 (UMLS CUI [1,3])
C0012634 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0013227 (UMLS CUI [2,3])
C1378698 (UMLS CUI [2,4])
C0012634 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C0683140 (UMLS CUI [3,3])
C0012634 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C0683141 (UMLS CUI [4,3])
C0524722 (UMLS CUI [5])
Gastrointestinal Diseases | Cardiovascular Diseases | Liver diseases | Kidney Diseases | Hematological Disease | Neoplastic disease | Endocrine System Diseases | Nervous system disorder | Immunodeficiency | Lung diseases | Disease
Item
the subject has evidence of clinically significant gastrointestinal, cardiovascular, hepatic, renal, hematological, neoplastic, endocrine, neurological, immunodeficiency, pulmonary, or other disorder or disease.
boolean
C0017178 (UMLS CUI [1])
C0007222 (UMLS CUI [2])
C0023895 (UMLS CUI [3])
C0022658 (UMLS CUI [4])
C0018939 (UMLS CUI [5])
C1882062 (UMLS CUI [6])
C0014130 (UMLS CUI [7])
C0027765 (UMLS CUI [8])
C0021051 (UMLS CUI [9])
C0024115 (UMLS CUI [10])
C0012634 (UMLS CUI [11])
Pharmaceutical Preparations Effect Serotonin | Non-Prescription Drugs Effect Serotonin | Antidepressive Agents | Sertraline | Fluoxetine | Fluvoxamine | venlafaxine
Item
use of all prescription drugs or non-prescriptions drugs that may effect serotonin such as antidepressants including sertraline, fluoxetine, fluvoxamine, venlafaxine.
boolean
C0013227 (UMLS CUI [1,1])
C1280500 (UMLS CUI [1,2])
C0036751 (UMLS CUI [1,3])
C0013231 (UMLS CUI [2,1])
C1280500 (UMLS CUI [2,2])
C0036751 (UMLS CUI [2,3])
C0003289 (UMLS CUI [3])
C0074393 (UMLS CUI [4])
C0016365 (UMLS CUI [5])
C0085228 (UMLS CUI [6])
C0078569 (UMLS CUI [7])
Substance Use Disorders | Narcotic Abuse
Item
the participant has a history of alcohol, narcotic, or any other drug abuse as defined by the diagnostic and statistical manual of the american psychiatric association, 4th edition (dsm iv) {american psychiatric association, 1994 #2} within the past 2 years.
boolean
C0038586 (UMLS CUI [1])
C0524661 (UMLS CUI [2])
Pregnancy
Item
pregnancy
boolean
C0032961 (UMLS CUI [1])