Age | Ankle pain Unilateral Duration | Conservative Treatment Benefit Lacking | Rest | Physical therapy | Orthoses | Analgesics | Adverse reaction to drug Side effects
Item
were 18 years of age or older, reported unilateral ankle pain for at least 6 months and had either reported no significant benefit from conservative treatment (rest, physical therapy, orthoses or pain medications etc.) or were unable to tolerate side effects of medications
boolean
C0001779 (UMLS CUI [1])
C0238656 (UMLS CUI [2,1])
C0205092 (UMLS CUI [2,2])
C0449238 (UMLS CUI [2,3])
C0459914 (UMLS CUI [3,1])
C0814225 (UMLS CUI [3,2])
C0332268 (UMLS CUI [3,3])
C0035253 (UMLS CUI [4])
C0949766 (UMLS CUI [5])
C0029365 (UMLS CUI [6])
C0002771 (UMLS CUI [7])
C0041755 (UMLS CUI [8,1])
C0879626 (UMLS CUI [8,2])
Radiography of ankle Kellgren-Lawrence score
Item
ankle radiographs taken within 6 months were equivalent to grade 2 or 3 according to the kellgren-lawrence grading system (grade 2, definite osteophytes and possible narrowing of joint space; grade 3, moderate multiple osteophytes, definite narrowing of joint space, some sclerosis and possible deformity of bone contour)22
boolean
C0203281 (UMLS CUI [1,1])
C3177117 (UMLS CUI [1,2])
Ankle Osteoarthritis Score
Item
had a current total aos score (described below) of > 3 and < 9 (possible range, 0-10)
boolean
C0409931 (UMLS CUI [1,1])
C0449820 (UMLS CUI [1,2])
Active | Bedridden Absent | WHEELCHAIR CONFINEMENT Absent | Able to walk Distance Short | Independent of Walkers | Independent of Crutches | Independent of Canes
Item
were normally active, not bedridden or confined to a wheelchair, and were able to walk 30 meters without the aid of a walker, crutches or cane
boolean
C0205177 (UMLS CUI [1])
C0741453 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0241735 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C2712089 (UMLS CUI [4,1])
C0012751 (UMLS CUI [4,2])
C1806781 (UMLS CUI [4,3])
C0332291 (UMLS CUI [5,1])
C0043016 (UMLS CUI [5,2])
C0332291 (UMLS CUI [6,1])
C0010397 (UMLS CUI [6,2])
C0332291 (UMLS CUI [7,1])
C0006856 (UMLS CUI [7,2])
NSAIDs Discontinue Willing | Analgesics Discontinue Willing
Item
were willing to discontinue all nonsteroidal anti-inflammatory drugs (nsaids) or other analgesic medication (except for rescue medication) for the duration of the study
boolean
C0003211 (UMLS CUI [1,1])
C1444662 (UMLS CUI [1,2])
C0600109 (UMLS CUI [1,3])
C0002771 (UMLS CUI [2,1])
C1444662 (UMLS CUI [2,2])
C0600109 (UMLS CUI [2,3])
Physical therapy Absent | Shoes Modification Absent | Orthotics Absent
Item
did not receive physical therapy or trial of shoe modifications or orthotics during the study period
boolean
C0949766 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0036988 (UMLS CUI [2,1])
C3840684 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
C0029365 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Pregnancy | Breast Feeding
Item
pregnant and lactating women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Osteoarthritis of ankle Bilateral | Treatment required for Both ankles
Item
bilateral ankle oa requiring treatment of both ankles
boolean
C0409931 (UMLS CUI [1,1])
C0238767 (UMLS CUI [1,2])
C0332121 (UMLS CUI [2,1])
C0230456 (UMLS CUI [2,2])
Chronic ankle instability
Item
chronic ankle instability
boolean
C3840097 (UMLS CUI [1])
Lower leg Trauma | Exception Ankle
Item
lower leg trauma other than within the ankle
boolean
C1140621 (UMLS CUI [1,1])
C3714660 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0003086 (UMLS CUI [2,2])
Orthopedic Surgical Procedure Spine | Orthopedic Surgical Procedure Hip | Orthopedic Surgical Procedure Knee
Item
previous orthopedic surgery on the spine, hip or knee
boolean
C1136201 (UMLS CUI [1,1])
C0037949 (UMLS CUI [1,2])
C1136201 (UMLS CUI [2,1])
C0019552 (UMLS CUI [2,2])
C1136201 (UMLS CUI [3,1])
C0022742 (UMLS CUI [3,2])
Joint infection Foot | Joint infection Ankle
Item
presence of active joint infections of foot or ankle
boolean
C0157749 (UMLS CUI [1,1])
C0016504 (UMLS CUI [1,2])
C0157749 (UMLS CUI [2,1])
C0003086 (UMLS CUI [2,2])
Operative procedure on ankle | Ankle arthroscopy
Item
previous surgery or arthroscopy on the ankle within 12 months
boolean
C0188412 (UMLS CUI [1])
C0188624 (UMLS CUI [2])
Intraarticular steroid injection Ankle Treated | Hyaluronic Acid Injection Ankle Treated
Item
intraarticular steroid or ha injection in the treated ankle within the past 6 months
boolean
C2064783 (UMLS CUI [1,1])
C0003086 (UMLS CUI [1,2])
C1522326 (UMLS CUI [1,3])
C0020196 (UMLS CUI [2,1])
C1828121 (UMLS CUI [2,2])
C0003086 (UMLS CUI [2,3])
C1522326 (UMLS CUI [2,4])
Anticoagulants | Immunosuppressive Agents
Item
treatment with anticoagulants or immunosuppressives
boolean
C0003280 (UMLS CUI [1])
C0021081 (UMLS CUI [2])
Rheumatoid Arthritis | Gout | Inflammatory Arthropathy
Item
history of rheumatoid arthritis, gout, or any other inflammatory arthropathy
boolean
C0003873 (UMLS CUI [1])
C0018099 (UMLS CUI [2])
C0003864 (UMLS CUI [3])
Hypersensitivity Protein Avian
Item
history of avian protein allergy
boolean
C0020517 (UMLS CUI [1,1])
C0033684 (UMLS CUI [1,2])
C0005595 (UMLS CUI [1,3])
Comorbidity Interferes with Clinical assessment | Neoplasms | Diabetes Mellitus | Paresis | Trauma
Item
presence of other comorbidity (neoplasm, diabetes mellitus, paresis, recent trauma, etc) or poor health status that would interfere with the clinical assessments during the study
boolean
C0009488 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C4534461 (UMLS CUI [1,3])
C0027651 (UMLS CUI [2])
C0011849 (UMLS CUI [3])
C0030552 (UMLS CUI [4])
C3714660 (UMLS CUI [5])