Age | Osteoarthritis of hip | Osteoarthritis, Knee
Item
men/women, 40 or older, diagnosed with hip or knee osteoarthritis.
boolean
C0001779 (UMLS CUI [1])
C0029410 (UMLS CUI [2])
C0409959 (UMLS CUI [3])
Hypertensive disease | Essential Hypertension Treated | Essential Hypertension Controlled
Item
hypertensive patient with treated and controlled essential hypertension.
boolean
C0020538 (UMLS CUI [1])
C0085580 (UMLS CUI [2,1])
C1522326 (UMLS CUI [2,2])
C0085580 (UMLS CUI [3,1])
C2911690 (UMLS CUI [3,2])
Antihypertensive therapy Quantity | Diuretics | Angiotensin-Converting Enzyme Inhibitors | Angiotensin II receptor antagonist | Adrenergic beta-Antagonists
Item
must receive at least one antihypertensive treatment from the following drug classes: diuretic, angiotensin-converting enzyme (ace) inhibitor, angiotensin receptor blockers (arb) or beta-blocker (bb).
boolean
C0585941 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0012798 (UMLS CUI [2])
C0003015 (UMLS CUI [3])
C0521942 (UMLS CUI [4])
C0001645 (UMLS CUI [5])
NSAIDs chronic | Acetaminophen chronic
Item
must be current chronic user of nsaids or acetaminophen.
boolean
C0003211 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
C0000970 (UMLS CUI [2,1])
C0205191 (UMLS CUI [2,2])
Analgesic therapy To be stopped
Item
must discontinue all analgesic therapy at screening.
boolean
C0412784 (UMLS CUI [1,1])
C1272691 (UMLS CUI [1,2])
Antihypertensive Agents Class Quantity
Item
more than two different classes of antihypertensive drugs.
boolean
C0003364 (UMLS CUI [1,1])
C0456387 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
Diabetic - poor control
Item
uncontrolled diabetes.
boolean
C0421258 (UMLS CUI [1])
Hepatic impairment | Renal Insufficiency
Item
hepatic or renal impairment.
boolean
C0948807 (UMLS CUI [1])
C1565489 (UMLS CUI [2])
Substance Use Disorders
Item
a history of alcohol/drug abuse.
boolean
C0038586 (UMLS CUI [1])
Gastric ulcer | Duodenal Ulcer | Gastroduodenal haemorrhage
Item
diagnosis of gastric or duodenal ulceration and/or history of significant gastro-duodenal bleeding.
boolean
C0038358 (UMLS CUI [1])
C0013295 (UMLS CUI [2])
C1096494 (UMLS CUI [3])
Congestive heart failure
Item
history of congestive heart failure.
boolean
C0018802 (UMLS CUI [1])
ECG abnormal
Item
clinically relevant abnormal ecg.
boolean
C0522055 (UMLS CUI [1])
Disease Interferes with Study Protocol | Disease At risk Patient safety
Item
current or history of a medical disease that could interfere with the study objectives or put the patient's safety at risk.
boolean
C0012634 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C2348563 (UMLS CUI [1,3])
C0012634 (UMLS CUI [2,1])
C1444641 (UMLS CUI [2,2])
C1113679 (UMLS CUI [2,3])
Anticoagulants | Anticoagulants Expected
Item
current or expected use of anticoagulants.
boolean
C0003280 (UMLS CUI [1])
C0003280 (UMLS CUI [2,1])
C1517001 (UMLS CUI [2,2])
Study Subject Participation Status | Clinical Trial
Item
participation within 30 days prior to pre-screening in another investigational study.
boolean
C2348568 (UMLS CUI [1])
C0008976 (UMLS CUI [2])