Age | Osteoarthritis of hip | Osteoarthritis, Knee
Item
men/women, 40 or older, diagnosed with hip or knee osteoarthritis.
boolean
C0001779 (UMLS CUI [1])
C0029410 (UMLS CUI [2])
C0409959 (UMLS CUI [3])
Hypertensive disease | Essential Hypertension Treated | Essential Hypertension Controlled
Item
hypertensive patient with treated and controlled essential hypertension.
boolean
C0020538 (UMLS CUI [1])
C0085580 (UMLS CUI [2,1])
C1522326 (UMLS CUI [2,2])
C0085580 (UMLS CUI [3,1])
C2911690 (UMLS CUI [3,2])
Antihypertensive therapy Quantity | Diuretics | Angiotensin-Converting Enzyme Inhibitors | Angiotensin II receptor antagonist | Adrenergic beta-Antagonists
Item
must receive at least one antihypertensive treatment from the following drug classes: diuretic, angiotensin-converting enzyme (ace) inhibitor, angiotensin receptor blocker (arb) or beta-blocker (bb).
boolean
C0585941 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0012798 (UMLS CUI [2])
C0003015 (UMLS CUI [3])
C0521942 (UMLS CUI [4])
C0001645 (UMLS CUI [5])
NSAIDs chronic | Acetaminophen chronic
Item
must be current chronic user of nsaids or acetaminophen.
boolean
C0003211 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
C0000970 (UMLS CUI [2,1])
C0205191 (UMLS CUI [2,2])
Analgesic therapy To be stopped
Item
must discontinue all analgesic therapy at screening.
boolean
C0412784 (UMLS CUI [1,1])
C1272691 (UMLS CUI [1,2])
Antihypertensive Agents Class Quantity
Item
more than two different classes of antihypertensive drugs.
boolean
C0003364 (UMLS CUI [1,1])
C0456387 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
Diabetic - poor control
Item
uncontrolled diabetes.
boolean
C0421258 (UMLS CUI [1])
Hepatic impairment | Renal Insufficiency
Item
hepatic or renal impairment.
boolean
C0948807 (UMLS CUI [1])
C1565489 (UMLS CUI [2])
Substance Use Disorders
Item
a history of alcohol/drug abuse.
boolean
C0038586 (UMLS CUI [1])
Gastric ulcer | Duodenal Ulcer | Gastroduodenal haemorrhage
Item
diagnosis of gastric or duodenal ulceration and/or history of significant gastro-duodenal bleeding.
boolean
C0038358 (UMLS CUI [1])
C0013295 (UMLS CUI [2])
C1096494 (UMLS CUI [3])
Congestive heart failure
Item
history of congestive heart failure.
boolean
C0018802 (UMLS CUI [1])
ECG abnormal
Item
clinically relevant abnormal ecg.
boolean
C0522055 (UMLS CUI [1])
Anticoagulants | Anticoagulants Expected
Item
current or expected use of anticoagulants.
boolean
C0003280 (UMLS CUI [1])
C0003280 (UMLS CUI [2,1])
C1517001 (UMLS CUI [2,2])
Disease Interferes with Study Protocol | Disease At risk Patient safety
Item
current or history of any medical disease that could interfere with the study objectives or put the patient's safety at risk.
boolean
C0012634 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C2348563 (UMLS CUI [1,3])
C0012634 (UMLS CUI [2,1])
C1444641 (UMLS CUI [2,2])
C1113679 (UMLS CUI [2,3])
Study Subject Participation Status | Clinical Trial
Item
participation within 30 days prior to pre-screening in another investigational study.
boolean
C2348568 (UMLS CUI [1])
C0008976 (UMLS CUI [2])