NSAID Index Knee Pain
Item
subject has been taking an nsaid at least 15 of the past 30 days for index knee pain
boolean
C0003211 (UMLS CUI [1,1])
C2986546 (UMLS CUI [1,2])
C0022742 (UMLS CUI [1,3])
C0030193 (UMLS CUI [1,4])
Osteoarthritis Femorotibial joint Medial Kellgren-Lawrence score | Index Joint X-ray
Item
grades 2 or 3 oa as defined by the kellgren and lawrence grading system of the medial tibiofemoral joint (joint space narrowing in the medial compartment > lateral compartment as assessed by x-ray) using the altman atlas of oa7. this must be documented with a report from an x-ray of the study joint taken either at screening or within 1 year prior to screening
boolean
C0029408 (UMLS CUI [1,1])
C1269072 (UMLS CUI [1,2])
C0205098 (UMLS CUI [1,3])
C3177117 (UMLS CUI [1,4])
C2986546 (UMLS CUI [2,1])
C0022417 (UMLS CUI [2,2])
C0034571 (UMLS CUI [2,3])
Knee Osteoarthritis ACR Criteria Fulfill | Knee pain | Age | Morning stiffness Duration | Joint crepitus | Bone tenderness | Bone enlargement | Joint warmth Synovial Membrane Palpable Absent
Item
subject meets american college of rheumatology (acr) clinical classification criteria for osteoarthritis of the knee, defined by the following: knee pain and at least 3 of the following: oage >50 omorning stiffness <30 minutes ocrepitus on active motion obony tenderness obony enlargement ono palpable warmth of synovium.
boolean
C0409959 (UMLS CUI [1,1])
C3273747 (UMLS CUI [1,2])
C1550543 (UMLS CUI [1,3])
C0231749 (UMLS CUI [2])
C0001779 (UMLS CUI [3])
C0457086 (UMLS CUI [4,1])
C0449238 (UMLS CUI [4,2])
C0231592 (UMLS CUI [5])
C0238807 (UMLS CUI [6])
C2203582 (UMLS CUI [7])
C0240095 (UMLS CUI [8,1])
C0039099 (UMLS CUI [8,2])
C0522499 (UMLS CUI [8,3])
C0332197 (UMLS CUI [8,4])
Allergic Reaction | Urticaria | Exanthema | Intolerance to celecoxib | Intolerance to Sulfonamides | Intolerance to Aspirin | Intolerance to Opioids | Intolerance to Oxycodone
Item
subject has a documented history of an allergic reaction (hives, rash, etc.) or a clinically significant intolerance to celecoxib, sulfonamides, aspirin, or opioids including oxycodone
boolean
C1527304 (UMLS CUI [1])
C0042109 (UMLS CUI [2])
C0015230 (UMLS CUI [3])
C1744706 (UMLS CUI [4,1])
C0538927 (UMLS CUI [4,2])
C1744706 (UMLS CUI [5,1])
C0038760 (UMLS CUI [5,2])
C1744706 (UMLS CUI [6,1])
C0004057 (UMLS CUI [6,2])
C1744706 (UMLS CUI [7,1])
C0242402 (UMLS CUI [7,2])
C1744706 (UMLS CUI [8,1])
C0030049 (UMLS CUI [8,2])
Pain outside Index Knee | Hip pain Interferes with Ability to walk | Back Pain Interferes with Ability to walk | Osteoarthritis Pain | Bilateral primary osteoarthritis of knee allowed
Item
significant pain outside the index knee, including significant hip or back pain that can not be distinguished from oa pain or that interferes with ability to walk. (patients with bilateral knee oa will be allowed into the study. the index knee should be defined as the more painful knee
boolean
C0030193 (UMLS CUI [1,1])
C0205101 (UMLS CUI [1,2])
C2986546 (UMLS CUI [1,3])
C0022742 (UMLS CUI [1,4])
C0019559 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0559964 (UMLS CUI [2,3])
C0004604 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C0559964 (UMLS CUI [3,3])
C0029408 (UMLS CUI [4,1])
C0030193 (UMLS CUI [4,2])
C2893930 (UMLS CUI [5,1])
C0683607 (UMLS CUI [5,2])
Patellofemoral osteoarthritis Index Knee Clinical examination
Item
predominantly patellofemoral knee osteoarthritis in the index knee as assessed by clinical examination
boolean
C1542808 (UMLS CUI [1,1])
C2986546 (UMLS CUI [1,2])
C0022742 (UMLS CUI [1,3])
C1456356 (UMLS CUI [1,4])
Unable to discontinue Analgesics Formulation | Exception Acetaminophen | Other Coding | Aspirin Low Dose Cardiac prophylaxis allowed
Item
subject who are unable to discontinue all formulations of prior analgesics other than acetaminophen during the washout period of the study, or who are anticipated to be unable to discontinue rescue medication for 24 hours prior to the respective visits. (low dose aspirin may be taken for cardiac prophylaxis
boolean
C1548265 (UMLS CUI [1,1])
C0002771 (UMLS CUI [1,2])
C0524527 (UMLS CUI [1,3])
C1705847 (UMLS CUI [2,1])
C0000970 (UMLS CUI [2,2])
C3846158 (UMLS CUI [3])
C2608320 (UMLS CUI [4,1])
C1739404 (UMLS CUI [4,2])
C0683607 (UMLS CUI [4,3])
Knee joint laxity Excessive | Indication Deficiency Ligament Functional
Item
excessive signal knee joint laxity indicative of functional ligamentous deficiency
boolean
C0574996 (UMLS CUI [1,1])
C0442802 (UMLS CUI [1,2])
C3146298 (UMLS CUI [2,1])
C0011155 (UMLS CUI [2,2])
C0023685 (UMLS CUI [2,3])
C0205245 (UMLS CUI [2,4])