Age
Item
1. age 18 years or older
boolean
C0001779 (UMLS CUI [1])
Life Expectancy
Item
2. life expectancy > 6 months
boolean
C0023671 (UMLS CUI [1])
Non-Small Cell Lung Carcinoma
Item
3. histologically or cytologically confirmed diagnosis of nsclc
boolean
C0007131 (UMLS CUI [1])
TNM clinical staging | Distant metastasis | Malignant Pleural Effusion Absent | Malignant pericardial effusion Absent
Item
4. patients with ajcc stage iv cancer with distant metastases and without malignant pleural or pericardial effusion at diagnosis and before start of study
boolean
C3258246 (UMLS CUI [1])
C1269798 (UMLS CUI [2])
C0080032 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C0220655 (UMLS CUI [4,1])
C0332197 (UMLS CUI [4,2])
Hydrothorax | Pleural effusion Cytologic Negative | Pleural effusion Except Effusion pleural bloody | Patients Stable status
Item
1. patients with pleural effusion that is transudative, cytologically negative, and non-bloody are eligible as long as they are stable and do not impair the ability to define tumor volumes.
boolean
C0020312 (UMLS CUI [1])
C0032227 (UMLS CUI [2,1])
C0205471 (UMLS CUI [2,2])
C1513916 (UMLS CUI [2,3])
C0032227 (UMLS CUI [3,1])
C0332300 (UMLS CUI [3,2])
C0240784 (UMLS CUI [3,3])
C0030705 (UMLS CUI [4,1])
C0205360 (UMLS CUI [4,2])
Diagnostic thoracentesis Pleural effusion
Item
2. if a pleural effusion is too small for diagnostic thoracentesis, the patient will be eligible.
boolean
C0843886 (UMLS CUI [1,1])
C0032227 (UMLS CUI [1,2])
Disorder of lymph node Primary Suitable Therapeutic radiology procedure | Disorder of lymph node regional Suitable Therapeutic radiology procedure
Item
5. primary and regional nodal disease that is encompassable in a reasonable radiotherapy portal:
boolean
C0272394 (UMLS CUI [1,1])
C0205225 (UMLS CUI [1,2])
C3900053 (UMLS CUI [1,3])
C1522449 (UMLS CUI [1,4])
C0272394 (UMLS CUI [2,1])
C0205147 (UMLS CUI [2,2])
C3900053 (UMLS CUI [2,3])
C1522449 (UMLS CUI [2,4])
Disease Site Quantity | Disease Amenable Therapeutic radiology procedure Imaging | Disease Amenable Therapeutic radiology procedure CT | Disease Amenable Therapeutic radiology procedure MRI | Disease Amenable Therapeutic radiology procedure Bone scan | Disease Amenable Therapeutic radiology procedure PET scan
Item
6. patients with 1-5 sites of disease and amenable to rt therapy as seen on standard imaging (ct, mri, bone scan, pet scan)
boolean
C0012634 (UMLS CUI [1,1])
C1515974 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0012634 (UMLS CUI [2,1])
C3900053 (UMLS CUI [2,2])
C1522449 (UMLS CUI [2,3])
C0011923 (UMLS CUI [2,4])
C0012634 (UMLS CUI [3,1])
C3900053 (UMLS CUI [3,2])
C1522449 (UMLS CUI [3,3])
C0040405 (UMLS CUI [3,4])
C0012634 (UMLS CUI [4,1])
C3900053 (UMLS CUI [4,2])
C1522449 (UMLS CUI [4,3])
C0024485 (UMLS CUI [4,4])
C0012634 (UMLS CUI [5,1])
C3900053 (UMLS CUI [5,2])
C1522449 (UMLS CUI [5,3])
C0203668 (UMLS CUI [5,4])
C0012634 (UMLS CUI [6,1])
C3900053 (UMLS CUI [6,2])
C1522449 (UMLS CUI [6,3])
C0032743 (UMLS CUI [6,4])
Measurable Disease Linear
Item
7. unidimensionally measurable disease (based on recist) is desirable but not strictly required.
boolean
C1513041 (UMLS CUI [1,1])
C0205132 (UMLS CUI [1,2])
Metastatic malignant neoplasm to brain | Whole brain radiation therapy | Stereotactic Radiosurgery | Excision Followed by Whole brain radiation therapy
Item
8. patients with brain metastases are allowed as long as they meet all other inclusion criteria. brain metastases must be treated with whole brain radiotherapy and stereotactic radiosurgery or surgical resection followed by whole brain radiotherapy.
boolean
C0220650 (UMLS CUI [1])
C1520143 (UMLS CUI [2])
C3846112 (UMLS CUI [3])
C0728940 (UMLS CUI [4,1])
C0332283 (UMLS CUI [4,2])
C1520143 (UMLS CUI [4,3])
ECOG performance status
Item
9. ecog performance status <2
boolean
C1520224 (UMLS CUI [1])
Absence Prior radiation therapy Tumor site Involved
Item
10. no prior rt to currently involved tumor sites
boolean
C0332197 (UMLS CUI [1,1])
C0279134 (UMLS CUI [1,2])
C0475445 (UMLS CUI [1,3])
C1314939 (UMLS CUI [1,4])
Peripheral Neuropathy CTCAE Grades
Item
11. baseline peripheral neuropathy < grade 1
boolean
C0031117 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
Oxygen saturation measurement on room air
Item
12. room air saturation (sao2) > 90%
boolean
C0523807 (UMLS CUI [1,1])
C2709070 (UMLS CUI [1,2])
Organ function | Bone Marrow function
Item
13. patients must have normal organ and marrow function
boolean
C0678852 (UMLS CUI [1])
C0005953 (UMLS CUI [2,1])
C0031843 (UMLS CUI [2,2])
Females & males of reproductive potential Contraceptive methods
Item
14. men and women of childbearing potential must be willing to consent to using effective contraception while on treatment and for at least 3 months thereafter.
boolean
C4034483 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Informed Consent
Item
15. signed informed consent
boolean
C0021430 (UMLS CUI [1])
Gender | Minorities
Item
16. inclusion of women and minorities
boolean
C0079399 (UMLS CUI [1])
C0026192 (UMLS CUI [2])
Therapeutic radiology procedure Treatment Plan Complete
Item
17. rt: patient must have a completed treatment plan approved by the protocol review team
boolean
C1522449 (UMLS CUI [1,1])
C0599880 (UMLS CUI [1,2])
C0205197 (UMLS CUI [1,3])
Comorbidity Uncontrolled | Communicable Disease | Symptomatic congestive heart failure | Angina, Unstable | Cardiac Arrhythmia | Mental disorders Limiting Protocol Compliance | Social situation Limiting Protocol Compliance
Item
1. uncontrolled intercurrent illness including, but not limited to, ongoing active infection, symptomatic congestive heart failure (chf), unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with the study requirements
boolean
C0009488 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0009450 (UMLS CUI [2])
C0742758 (UMLS CUI [3])
C0002965 (UMLS CUI [4])
C0003811 (UMLS CUI [5])
C0004936 (UMLS CUI [6,1])
C0439801 (UMLS CUI [6,2])
C0525058 (UMLS CUI [6,3])
C0748872 (UMLS CUI [7,1])
C0439801 (UMLS CUI [7,2])
C0525058 (UMLS CUI [7,3])
Pulmonary Dysfunction | Cardiomyopathy | Congestive heart failure | Coronary heart disease Physician Decision
Item
2. patients with clinically significant pulmonary dysfunction, cardiomyopathy, or any history of clinically significant chf are excluded. the exclusion of patients with active coronary heart disease will be at the discretion of the attending physician.
boolean
C1709770 (UMLS CUI [1])
C0878544 (UMLS CUI [2])
C0018802 (UMLS CUI [3])
C0010068 (UMLS CUI [4,1])
C1709536 (UMLS CUI [4,2])
Atelectasis | Gross tumor volume CT Difficult
Item
3. patients with significant atelectasis such that ct definition of the gross tumor volume (gtv) is difficult to determine.
boolean
C0004144 (UMLS CUI [1])
C0475645 (UMLS CUI [2,1])
C0040405 (UMLS CUI [2,2])
C0332218 (UMLS CUI [2,3])
Lung Portion Free of Tumor
Item
4. < 1000 cc of tumor free lung.
boolean
C0024109 (UMLS CUI [1,1])
C0449719 (UMLS CUI [1,2])
C0332296 (UMLS CUI [1,3])
C0027651 (UMLS CUI [1,4])
Tumor Volume | Tumor Location | Requirement Lung volume PTV Percentage
Item
5. tumor volume and location which requires a lung volume-ptv >40% to receive >20 gy (v20 <40%).
boolean
C0475276 (UMLS CUI [1])
C0027651 (UMLS CUI [2,1])
C1515974 (UMLS CUI [2,2])
C1514873 (UMLS CUI [3,1])
C0231953 (UMLS CUI [3,2])
C0454199 (UMLS CUI [3,3])
C0439165 (UMLS CUI [3,4])
Exudative pleural effusion | Effusion pleural bloody | Pleural Effusion, Malignant
Item
6. patients with exudative, bloody, or cytologically malignant effusions are not eligible.
boolean
C3887491 (UMLS CUI [1])
C0240784 (UMLS CUI [2])
C0080032 (UMLS CUI [3])
Pregnancy | Breast Feeding | Childbearing Potential Contraceptive methods
Item
7. pregnancy or breast feeding (women of child-bearing potential are eligible, but must consent to using effective contraception during therapy and for at least 3 months after completing therapy)
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
Communicable Disease Uncontrolled
Item
8. patients must have no uncontrolled active infection other than that not curable without treatment of their cancer.
boolean
C0009450 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Severe allergy Docetaxel | Severe allergy Drug Formulation Polysorbate 80
Item
9. patients with a history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80.
boolean
C2945656 (UMLS CUI [1,1])
C0246415 (UMLS CUI [1,2])
C2945656 (UMLS CUI [2,1])
C0524527 (UMLS CUI [2,2])
C0032601 (UMLS CUI [2,3])
Investigational New Drugs
Item
10. patient may not be receiving any other investigational agents.
boolean
C0013230 (UMLS CUI [1])