Solid Neoplasm incurable | Systemic therapy Quantity
Item
1. phase 1: any incurable solid malignancy, with no more than 3 prior systemic treatment regimens.
boolean
C0280100 (UMLS CUI [1,1])
C0175969 (UMLS CUI [1,2])
C1515119 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
Non-Small Cell Lung Carcinoma Advanced TNM clinical staging | Pleural Effusion, Malignant | Systemic therapy Quantity failed
Item
phase 2: histologic diagnosis of advanced nsclc, stage iiib with malignant pleural effusion or stage iv per american joint committee on cancer staging criteria for nsclc. patients must have failed 1 or 2 prior systemic treatment regimen(s).
boolean
C0007131 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C3258246 (UMLS CUI [1,3])
C0080032 (UMLS CUI [2])
C1515119 (UMLS CUI [3,1])
C1265611 (UMLS CUI [3,2])
C0231175 (UMLS CUI [3,3])
ECOG performance status
Item
2. performance status of 0, 1, or 2 on the eastern cooperative oncology group (ecog) scale
boolean
C1520224 (UMLS CUI [1])
Prior Chemotherapy Completed | Toxicity Patient recovered | Exception Alopecia
Item
3. prior chemotherapy must be completed at least 2 weeks prior to study enrollment, and the patient must have recovered from acute toxic effects (except alopecia) prior to enrollment.
boolean
C1514457 (UMLS CUI [1,1])
C0205197 (UMLS CUI [1,2])
C0600688 (UMLS CUI [2,1])
C1115804 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0002170 (UMLS CUI [3,2])
Prior radiation therapy Bone Marrow Percentage | Prior radiation therapy Completed | Toxicity Patient recovered | Exception Alopecia
Item
4. prior radiotherapy is allowed to < 25% of the bone marrow prior radiotherapy must be completed at least 2 weeks before study enrollment, and the patient must have recovered from acute toxic effects (except alopecia) prior to enrollment.
boolean
C0279134 (UMLS CUI [1,1])
C0005953 (UMLS CUI [1,2])
C0439165 (UMLS CUI [1,3])
C0279134 (UMLS CUI [2,1])
C0205197 (UMLS CUI [2,2])
C0600688 (UMLS CUI [3,1])
C1115804 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0002170 (UMLS CUI [4,2])
Disease Non-Measurable | Measurable Disease
Item
5. non-measurable or measurable disease as defined by recist.
boolean
C0012634 (UMLS CUI [1,1])
C1518373 (UMLS CUI [1,2])
C1513041 (UMLS CUI [2])
Criteria Fulfill
Item
patients who
boolean
C0243161 (UMLS CUI [1,1])
C1550543 (UMLS CUI [1,2])
Lacking Able to swallow Tablets
Item
1. are unable to swallow tablets.
boolean
C0332268 (UMLS CUI [1,1])
C2712086 (UMLS CUI [1,2])
C0039225 (UMLS CUI [1,3])
Unable to discontinue Carbamazepine | Unable to discontinue Phenobarbital | Unable to discontinue Phenytoin
Item
2. unable to discontinue use of carbamazepine, phenobarbital, and phenytoin.
boolean
C1548265 (UMLS CUI [1,1])
C0006949 (UMLS CUI [1,2])
C1548265 (UMLS CUI [2,1])
C0031412 (UMLS CUI [2,2])
C1548265 (UMLS CUI [3,1])
C0031507 (UMLS CUI [3,2])
Epidermal growth factor receptor inhibitor | erlotinib
Item
3. have previously been treated with an epidermal growth factor receptor (egfr) inhibitor, including erlotinib.
boolean
C1443775 (UMLS CUI [1])
C1135135 (UMLS CUI [2])
Cancer treatment Other
Item
4. are receiving concurrent administration of any other antitumor therapy.
boolean
C0920425 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
Drugs, Non-Prescription
Item
5. have received treatment within the last 30 days with a drug (not including study drug) that has not received regulatory approval for any indication at the time of study entry.
boolean
C0013231 (UMLS CUI [1])