Non-Small Cell Lung Carcinoma Advanced | Non-small cell lung cancer metastatic
Item
subject must be histologically or cytologically diagnosed with advanced or metastatic nsclc
boolean
C0007131 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C0278987 (UMLS CUI [2])
Measurable lesion Quantity CT scan
Item
subjects must have at least one lesion measurable by ct scan as defined by recist
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0040405 (UMLS CUI [1,3])
Therapeutic radiology procedure Absent Measurable lesion
Item
the measurable lesion may have not received radiation therapy
boolean
C1522449 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C1513041 (UMLS CUI [1,3])
ECOG performance status
Item
subject has an eastern cooperative oncology group (ecog) performance status of 0-2
boolean
C1520224 (UMLS CUI [1])
Line Systemic therapy Quantity | Therapeutic procedure Quantity Non-Small Cell Lung Carcinoma Advanced | Therapeutic procedure Quantity Non-small cell lung cancer metastatic | Chemotherapy Neoadjuvant Systemic Non-Small Cell Lung Carcinoma | Adjuvant Chemotherapy Systemic Non-Small Cell Lung Carcinoma
Item
subject has received at least one prior line of systemic treatment but no more than two treatment regimen(s) for advanced or metastatic nsclc. in addition, the subject may have received systemic neo-adjuvant or adjuvant chemotherapy for nsclc
boolean
C4524693 (UMLS CUI [1,1])
C1515119 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0087111 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0007131 (UMLS CUI [2,3])
C0205179 (UMLS CUI [2,4])
C0087111 (UMLS CUI [3,1])
C1265611 (UMLS CUI [3,2])
C0278987 (UMLS CUI [3,3])
C0392920 (UMLS CUI [4,1])
C0600558 (UMLS CUI [4,2])
C0205373 (UMLS CUI [4,3])
C0007131 (UMLS CUI [4,4])
C0085533 (UMLS CUI [5,1])
C0205373 (UMLS CUI [5,2])
C0007131 (UMLS CUI [5,3])
Organ function
Item
adequate organ function
boolean
C0678852 (UMLS CUI [1])
VEGFR Tyrosine Kinase Inhibitor Targeted Therapy | PDGF Tyrosine kinase inhibitor Targeted Therapy | Avastin allowed
Item
subject has received targeted vegf/pdgf tki (tyrosine kinase inhibitor) therapy. prior avastin is allowed.
boolean
C2985521 (UMLS CUI [1,1])
C2985566 (UMLS CUI [1,2])
C0032200 (UMLS CUI [2,1])
C1268567 (UMLS CUI [2,2])
C2985566 (UMLS CUI [2,3])
C1135130 (UMLS CUI [3,1])
C0683607 (UMLS CUI [3,2])
Metastatic malignant neoplasm to brain untreated | Meningeal Carcinomatosis untreated
Item
subject has untreated brain or meningeal metastases.
boolean
C0220650 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C0220654 (UMLS CUI [2,1])
C0332155 (UMLS CUI [2,2])
Weight decreased Percentage
Item
history of greater than 10% weight loss
boolean
C1262477 (UMLS CUI [1,1])
C0439165 (UMLS CUI [1,2])
Hemoptysis
Item
subject has clinically relevant hemoptysis
boolean
C0019079 (UMLS CUI [1])
Proteinuria CTCAE Grades
Item
the subject has proteinuria ctc grade > 1
boolean
C0033687 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
Uncontrolled hypertension Symptomatic | Uncontrolled hypertension Persistent | Diastolic blood pressure | Systolic Pressure | Control of blood pressure Associated with Intervention | Control of blood pressure Without Intervention
Item
the subject currently exhibits symptomatic or persistent, uncontrolled hypertension defined as diastolic blood pressure > 100 mmhg or systolic blood pressure > 150 mmhg. subjects may be re-screened if blood pressure is shown to be controlled with or without intervention.
boolean
C1868885 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C1868885 (UMLS CUI [2,1])
C0205322 (UMLS CUI [2,2])
C0428883 (UMLS CUI [3])
C0871470 (UMLS CUI [4])
C1753303 (UMLS CUI [5,1])
C0332281 (UMLS CUI [5,2])
C0184661 (UMLS CUI [5,3])
C1753303 (UMLS CUI [6,1])
C0332288 (UMLS CUI [6,2])
C0184661 (UMLS CUI [6,3])
Left ventricular ejection fraction
Item
the subject has a documented left ventricular ejection fraction < 50%
boolean
C0428772 (UMLS CUI [1])