Criteria Fulfill
Item
patients must have/be
boolean
C0243161 (UMLS CUI [1,1])
C1550543 (UMLS CUI [1,2])
Age | Age Relationship Physical Condition Excellent
Item
1. age 18 to 65 years. patients between age 66 and 69 may be enrolled if judged to be in excellent physical condition as per treating physician and study investigator and based on institutional practice.
boolean
C0001779 (UMLS CUI [1])
C0001779 (UMLS CUI [2,1])
C0439849 (UMLS CUI [2,2])
C3714565 (UMLS CUI [2,3])
C1961136 (UMLS CUI [2,4])
Lymphoma, Non-Hodgkin | Lymphoma, Follicular | Marginal Zone Lymphoma | Small Lymphocytic Lymphoma | Mantle cell lymphoma | Transformation Indolent Non-Hodgkin Lymphoma Aggressive Non-Hodgkin Lymphoma
Item
2. diagnosis of non-hodgkin lymphoma, follicular, marginal zone, small lymphocytic lymphoma, mantle cell lymphoma or transformed from an indolent nhl to aggressive histology disease lymphoma as defined by the world health organization.
boolean
C0024305 (UMLS CUI [1])
C0024301 (UMLS CUI [2])
C1367654 (UMLS CUI [3])
C0855095 (UMLS CUI [4])
C0334634 (UMLS CUI [5])
C0040682 (UMLS CUI [6,1])
C1334170 (UMLS CUI [6,2])
C1332225 (UMLS CUI [6,3])
Recurrent disease | Refractory Disease Post Cycle Quantity Salvage Therapy | Partial response failed | Status post Cycle Quantity Salvage Therapy | ESHAP regimen | Recurrent disease Post Transplantation of autologous hematopoietic stem cell
Item
3. disease relapsed after, refractory or failing to achieve a pr after two or more cycles of intensive salvage chemotherapy (r-eshap or other) or disease relapsed after autologous stem cell transplantation. poor partial response is defined as less than 50% reduction of tumor size. salvage chemotherapy has to be administered after either 1st, 2nd or 3rd relapse
boolean
C0277556 (UMLS CUI [1])
C1514815 (UMLS CUI [2,1])
C0687676 (UMLS CUI [2,2])
C1302181 (UMLS CUI [2,3])
C1265611 (UMLS CUI [2,4])
C0085405 (UMLS CUI [2,5])
C1521726 (UMLS CUI [3,1])
C0231175 (UMLS CUI [3,2])
C0231290 (UMLS CUI [4,1])
C1302181 (UMLS CUI [4,2])
C1265611 (UMLS CUI [4,3])
C0085405 (UMLS CUI [4,4])
C0384397 (UMLS CUI [5])
C0277556 (UMLS CUI [6,1])
C0687676 (UMLS CUI [6,2])
C1831743 (UMLS CUI [6,3])
Disease CD20 Antigen Expressed
Item
4. disease expressing the cd 20 antigen
boolean
C0012634 (UMLS CUI [1,1])
C0054946 (UMLS CUI [1,2])
C0017262 (UMLS CUI [1,3])
ECOG performance status
Item
5. ecog performance status 0-2
boolean
C1520224 (UMLS CUI [1])
Nonmyeloablative stem cell transplantation Receive Ability | Zevalin
Item
6. judged to be able to tolerate nst and zevalin treatment based on institutional criteria.
boolean
C1831742 (UMLS CUI [1,1])
C1514756 (UMLS CUI [1,2])
C0085732 (UMLS CUI [1,3])
C0919274 (UMLS CUI [2])
Informed Consent
Item
7. signed written informed consent
boolean
C0021430 (UMLS CUI [1])
HLA Match Sibling Quantity | Absence Contraindication Tissue Donation | Consent Tissue Donation
Item
8. at least one fully hla matched sibling without evident contraindications to the donation procedures and willing to sign consent for donation
boolean
C4330149 (UMLS CUI [1,1])
C0037047 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0332197 (UMLS CUI [2,1])
C0522473 (UMLS CUI [2,2])
C0080231 (UMLS CUI [2,3])
C1511481 (UMLS CUI [3,1])
C0080231 (UMLS CUI [3,2])
Criteria Fulfill
Item
patients must not have/be
boolean
C0243161 (UMLS CUI [1,1])
C1550543 (UMLS CUI [1,2])
Abnormal renal function | Serum creatinine raised
Item
1. abnormal renal function (creatinine > 1.5 x upper limit of normal (uln)
boolean
C0151746 (UMLS CUI [1])
C0700225 (UMLS CUI [2])
Liver Dysfunction | Serum bilirubin increased | Alanine aminotransferase increased | Aspartate aminotransferase increased
Item
2. abnormal hepatic function (bilirubin > 2 x uln, alt/ast>2x uln)
boolean
C0086565 (UMLS CUI [1])
C0859062 (UMLS CUI [2])
C0151905 (UMLS CUI [3])
C0151904 (UMLS CUI [4])
Cardiac ejection fraction | Decreased cardiac function
Item
3. cardiac ejection fraction <40% and/or other significant cardiac compromise
boolean
C0232174 (UMLS CUI [1])
C0232166 (UMLS CUI [2])
Defect Severe Pulmonary function tests | Oxygen therapy support
Item
4. severe defects in pulmonary function tests or receiving continuous oxygen
boolean
C1457869 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0024119 (UMLS CUI [1,3])
C3872899 (UMLS CUI [2])
Comorbidity Severe | Symptomatic congestive heart failure | Cardiac Arrhythmia Severe | Uncontrolled hypertension | Diabetes Mellitus | Nervous system disorder Severe | Mental Disorders, Severe | HIV Seropositivity
Item
5. severe concurrent illness, such as symptomatic congestive heart failure, severe arrhythmias, uncontrolled hypertension, diabetes, severe neurologic or psychiatric disorder or known hiv positive
boolean
C0009488 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0742758 (UMLS CUI [2])
C0003811 (UMLS CUI [3,1])
C0205082 (UMLS CUI [3,2])
C1868885 (UMLS CUI [4])
C0011849 (UMLS CUI [5])
C0027765 (UMLS CUI [6,1])
C0205082 (UMLS CUI [6,2])
C4046029 (UMLS CUI [7])
C0019699 (UMLS CUI [8])
Cancer Other Primary site | Cancer Other Histology | Exception Carcinoma in situ of uterine cervix | Exception Basal cell carcinoma Treated | Exception Superficial carcinoma of urinary bladder TNM clinical staging | Impact Life Expectancy | Exception Curative treatment Malignant Neoplasms
Item
6. previous or concurrent cancer that is distinct in primary site or histology from the cancer being evaluated except cervical carcinoma in situ, treated basal cell carcinoma, superficial bladder tumors (ta, tis & t1) that may impact on patients life expectancy or any cancer curatively treated < 3 years prior to study entry.
boolean
C1707251 (UMLS CUI [1,1])
C0475447 (UMLS CUI [1,2])
C1707251 (UMLS CUI [2,1])
C4048239 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0851140 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0007117 (UMLS CUI [4,2])
C1522326 (UMLS CUI [4,3])
C1705847 (UMLS CUI [5,1])
C1336527 (UMLS CUI [5,2])
C3258246 (UMLS CUI [5,3])
C4049986 (UMLS CUI [6,1])
C0023671 (UMLS CUI [6,2])
C1705847 (UMLS CUI [7,1])
C1273390 (UMLS CUI [7,2])
C0006826 (UMLS CUI [7,3])
Allogeneic bone marrow transplantation
Item
7. history of prior allogeneic bone marrow transplant
boolean
C0149615 (UMLS CUI [1])
Hepatitis B | Hepatitis C | Hepatitis B surface antigen positive
Item
8. evidence of active hepatitis b or c infection or positivity for hepatitis-b surface antigen
boolean
C0019163 (UMLS CUI [1])
C0019196 (UMLS CUI [2])
C0149709 (UMLS CUI [3])
Immediate hypersensitivity Zevalin Component | Anaphylaxis Zevalin Component | Human anti-mouse antibody Present
Item
9. known type 1 hypersensitivity or anaphylactic proteins to any component of the zevalin therapy or a history or presence of human anti-mouse antibodies (hama)
boolean
C0020523 (UMLS CUI [1,1])
C0919274 (UMLS CUI [1,2])
C1705248 (UMLS CUI [1,3])
C0002792 (UMLS CUI [2,1])
C0919274 (UMLS CUI [2,2])
C1705248 (UMLS CUI [2,3])
C1291910 (UMLS CUI [3,1])
C0150312 (UMLS CUI [3,2])
Pregnancy | Breast Feeding | Females & males of reproductive potential Contraceptive methods Absent
Item
10. a female patient who is pregnant or breast feeding and an adult of reproductive potential who is not employing an effective method of birth control during the study.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C4034483 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C0332197 (UMLS CUI [3,3])
Central nervous system lymphoma
Item
11. cns lymphoma
boolean
C0742472 (UMLS CUI [1])
Communicable Disease | Communicable Disease Suspected
Item
12. ongoing confirmed or suspected significant infection
boolean
C0009450 (UMLS CUI [1])
C0009450 (UMLS CUI [2,1])
C0750491 (UMLS CUI [2,2])
Radioimmunotherapy
Item
13. prior treatment with radioimmunotherapy
boolean
C0085101 (UMLS CUI [1])
Condition Preventing Nonmyeloablative stem cell transplantation
Item
14. other condition preventing participation in standard nst
boolean
C0348080 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C1831742 (UMLS CUI [1,3])
HLA Match Sibling Lacking
Item
15. no fully matched sibling donor
boolean
C4330149 (UMLS CUI [1,1])
C0037047 (UMLS CUI [1,2])
C0332268 (UMLS CUI [1,3])