Gender | Age | HER2 negative carcinoma of breast
Item
female patients at least 18 years old with her-2 negative breast cancer.
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
C2316304 (UMLS CUI [3])
Circulating Neoplastic Cells HER2 Positive Peripheral blood specimen | Circulating Neoplastic Cells EGFR Positive Peripheral blood specimen
Item
patients must have evidence of her-2 or egfr positive circulating tumour cells in a peripheral blood sample taken at screening visit.
boolean
C0027625 (UMLS CUI [1,1])
C2348909 (UMLS CUI [1,2])
C1292451 (UMLS CUI [1,3])
C0027625 (UMLS CUI [2,1])
C4525189 (UMLS CUI [2,2])
C1292451 (UMLS CUI [2,3])
Neoplasm Metastasis Measurable | Absence Metastatic malignant neoplasm to brain Requirement Local Therapy
Item
patients must have measurable, metastatic disease and no brain metastasis requiring local therapy.
boolean
C0027627 (UMLS CUI [1,1])
C1513040 (UMLS CUI [1,2])
C0332197 (UMLS CUI [2,1])
C0220650 (UMLS CUI [2,2])
C1514873 (UMLS CUI [2,3])
C1517925 (UMLS CUI [2,4])
ECOG performance status | Life Expectancy | Organ function
Item
other criteria include ecog score 0 to 2, life expectancy > 12 weeks, baseline organ function at screening visit,
boolean
C1520224 (UMLS CUI [1])
C0023671 (UMLS CUI [2])
C0678852 (UMLS CUI [3])
Anthracyclines | Taxanes | Neoadjuvant Therapy | Adjuvant therapy | Advanced phase | Line of Therapy Quantity Neoplasm Metastasis
Item
previous treatment with anthracyclines and/or taxanes in the neo-adjuvant, adjuvant or advanced setting, and at least one line of treatment for metastatic disease.
boolean
C0282564 (UMLS CUI [1])
C0796419 (UMLS CUI [2])
C0600558 (UMLS CUI [3])
C0677850 (UMLS CUI [4])
C0205179 (UMLS CUI [5])
C4524693 (UMLS CUI [6,1])
C1265611 (UMLS CUI [6,2])
C0027627 (UMLS CUI [6,3])
Medical condition Unstable | Pregnancy | Breast Feeding
Item
unstable medical conditions, pregnant or lactating women.
boolean
C3843040 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
C0032961 (UMLS CUI [2])
C0006147 (UMLS CUI [3])
Informed Consent Unable
Item
inability to provide informed consent.
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
Integrity Physical Lacking Upper gastrointestinal tract
Item
lack of physical integrity of the upper gastrointestinal (gi) tract.
boolean
C1947912 (UMLS CUI [1,1])
C0205485 (UMLS CUI [1,2])
C0332268 (UMLS CUI [1,3])
C1268997 (UMLS CUI [1,4])
Malignant Neoplasms | Exception Basal cell carcinoma | Exception Carcinoma in Situ | Exception Cancer treatment Concurrent | Exception Chemotherapy | Exception Hormone Therapy | Exception Investigational New Drugs
Item
co-existing malignancy or malignancies within the last 5 years with the exception of basal cell carcinoma or in-situ carcinoma, concurrent anti-cancer therapies (chemo or hormonal therapy) or investigational drugs other than study drug.
boolean
C0006826 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0007099 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0920425 (UMLS CUI [4,2])
C0205420 (UMLS CUI [4,3])
C1705847 (UMLS CUI [5,1])
C0392920 (UMLS CUI [5,2])
C1705847 (UMLS CUI [6,1])
C0279025 (UMLS CUI [6,2])
C1705847 (UMLS CUI [7,1])
C0013230 (UMLS CUI [7,2])
Therapeutic radiology procedure Target Lesion Only | Diphosphonates | Secondary malignant neoplasm of bone Target Lesion Only
Item
concurrent radiotherapy to the only target lesion or concurrent bisphosphonates if bone metastases are the only target lesions.
boolean
C1522449 (UMLS CUI [1,1])
C2986546 (UMLS CUI [1,2])
C0205171 (UMLS CUI [1,3])
C0012544 (UMLS CUI [2])
C0153690 (UMLS CUI [3,1])
C2986546 (UMLS CUI [3,2])
C0205171 (UMLS CUI [3,3])
Therapeutic procedure Against HER2 | Therapeutic procedure Against EGFR
Item
previous treatment with anti her-2 or anti-egfr therapies.
boolean
C0087111 (UMLS CUI [1,1])
C0521124 (UMLS CUI [1,2])
C0069515 (UMLS CUI [1,3])
C0087111 (UMLS CUI [2,1])
C0521124 (UMLS CUI [2,2])
C0034802 (UMLS CUI [2,3])
Therapeutic procedure Inappropriate Patient Care Management
Item
protocol specified treatment regimens that would be inappropriate for the management of the subject.
boolean
C0087111 (UMLS CUI [1,1])
C1548788 (UMLS CUI [1,2])
C0030677 (UMLS CUI [1,3])